The effect of smoking on early implant failure

Bruyn, Hugo De; Collaert, Bruno

doi:10.1034/j.1600-0501.1994.050410.x

Cited by 205 publications

(168 citation statements)

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“…A meta-analysis of the literature conducted by Papapanou (1996) for the 1996 World Workshop in Periodontics revealed that smokers have an almost 3-fold increase in their risk for severe periodontal disease vs non-smokers. Evidence also indicates that failures of endosseous dental implants (relating to osseointegration) are increased in smokers vs non-smokers (Bain & Moy 1993, De Bruyn & Collaert 1994.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol

Singh¹,

Casper²,

Fritz³

et al. 2000

Journal of Endocrinology

129

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Aryl hydrocarbon receptor (AhR) ligands are environmental contaminants found in cigarette smoke and other sources of air pollution. The prototypical compound is TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), also known as dioxin. There is an increasing body of knowledge linking cigarette smoking to osteoporosis and periodontal disease, but the direct effects of smokeassociated aryl hydrocarbons on bone are not well understood. Through the use of resveratrol (3,5,4 -trihydroxystilbene), a plant antifungal compound that we have recently demonstrated to be a pure AhR antagonist, we have investigated the effects of TCDD on osteogenesis. It was postulated that TCDD would inhibit osteogenesis in bone-forming cultures and that this inhibition would be antagonized by resveratrol. We employed the chicken periosteal osteogenesis (CPO) model, which has been shown to form bone in vitro in a pattern morphologically and biochemically similar to that seen in vivo, as well as a rat stromal cell bone nodule formation model. In the CPO model, alkaline phosphatase (AP) activity was reduced by up to 50% (P<0·01 vs control) in the presence of 10 9 M TCDD and these effects were reversed by 10 6 M resveratrol (P<0·05 vs TCDD alone). TCDD-mediated inhibition of osteogenesis was restricted primarily to the osteoblastic differentiation phase (days 0-2) as later addition did not appear to have any effects. Message levels for important bone-associated proteins (in the CPO model) such as collagen type I, osteopontin, bone sialoprotein and AP were inhibited by TCDD, an effect that was antagonized by resveratrol. Similar findings were obtained using the rat stromal bone cell line. TCDD (at concentrations as low as 10 10 M) caused an approximately 33% reduction in AP activity, which was abrogated by 3·5 10 7 M resveratrol. TCDD also induced a marked reduction in mineralization (75%) which was completely antagonized by resveratrol. These data suggest that AhR ligands inhibit osteogenesis probably through inhibition of osteodifferentiation and that this effect can be antagonized by resveratrol. Since high levels of AhR ligands are found in cigarette smoke, and further since smoking is an important risk factor in both osteoporosis and periodontal disease, it may be postulated that AhR ligands are the component of cigarette smoke linking smoking to osteoporosis and periodontal disease. If so, resveratrol could prove to be a promising preventive or therapeutic agent for smoking-related bone loss.

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Section: Introductionmentioning

confidence: 99%

Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol

Singh¹,

Casper²,

Fritz³

et al. 2000

Journal of Endocrinology

129

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“…[15] An added failure rate of about 8% was noticed in smokers that occurred either at the implant exposure or after a short time of implant loading. [16] In this study, the effect of conventional versus Schlosser's techniques during competes denture construction was compared to evaluate the effect of these different approachs on the implant stability and marginal bone loss. Complete dentures fabricated using "Schlosser's Technique" in which the try-in stage is followed by completed construction of upper denture then readjusting occlusion of lower trial denture base against the remounted upper processed denture, and finally, the construction of lower complete.…”

Section: Discussionmentioning

confidence: 99%

Randomized study on effect of conventional versus Schlosser's fabrication techniques for complete over dentures supported by mandibular implants

Abdelaal¹

2017

IDJAR

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Background:The conventional method of complete denture fabrication has many problems that include lack of uniform distribution of occlusal forces to the basal seat, causing inflammation, ulcers in the supporting tissues, more rapid residual ridge resorption, increase patient discomfort, increase parafunctional movements, and the need for frequent adjustments. Aim: The aim of this study is to evaluate and compare the effect of two different fabrication techniques for complete over dentures supported by mandibular implants. Methodology: A total of 24 edentulous subjects were eligible for inclusion. Using a random sampling system, conventional or Schlosser's technique was used to fabricate the dentures. Two implants were placed in the canine area of all patients. After 3 months, ball attachments were connected to the implants, and the denture delivered with the retentive components incorporated in the denture base. At the follow-up examinations, implant stability and marginal bone loss were evaluated at 3, 6, and 12 months. Results: The sample of 24 patients, with a mean age of 55.2 years, was included in this study. All patients attended the 12-month follow-up. The complete denture fabricated by Schlosser's technique showed significant more implant stability and less bone loss when compared to conventionally fabricated dentures. Conclusion: The Schlosser's technique is considered as predictable methods of complete denture construction. Consequently, this technique has a positive effect on the implants that supported mandibular overdenture. The more harmonious occlusion result from this technique results in better implant stability and decreases the rate of bone loss around the implants. Clinical Significance: The denture fabricated with Schlosser's technique results in more harmonious occlusion that suggested as one requirement of successful dental implants.

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“…5 These also compromise the healing process 6 and increase the risk of implant failure. [7][8][9][10][11] It has been suggested that smokers are informed of this risk rather than smoking being seen as a contraindication to implant treatment. 12 All three patients had a history of cigarette smoking and two had high alcohol consumption, and they represented high risk cases for developing oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Dental implants and squamous cell carcinoma in the at risk patient – report of three cases

et al. 2008

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The effect of smoking on early implant failure

Cited by 205 publications

References 0 publications

Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol

Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol

Randomized study on effect of conventional versus Schlosser's fabrication techniques for complete over dentures supported by mandibular implants

Dental implants and squamous cell carcinoma in the at risk patient – report of three cases

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