The effect of smoking on peripheral insulin sensitivity and plasma endothelin level

Borissova, A M; Tankova, Tsvetalina; Кirilov, Georgi; Dakovska, Lilia; Krivoshiev, S

doi:10.1016/s1262-3636(07)70100-3

Cited by 35 publications

(23 citation statements)

References 34 publications

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“…This process-induced increase in the synthesis of ET-1 contributes to local tissue hypoxia, which leads to a decrease in the peripheral glucose uptake. 13 This is confirmed by the results of earlier studies, where smoking healthy persons and smoking patients showed higher ET-1 levels in the plasma when compared with nonsmoking groups. In addition, the ET-1 expression determined by means of a densimetric analysis was the highest in the group of smoking CP patients ( Table 6).…”

Section: Discussionsupporting

confidence: 82%

“…22,30 However, in many studies, it is emphasized that substances contained in tobacco smoke have a direct and indirect impact on the increased ET-1 expression, which leads to a high concentration of this peptide in the blood of smokers, regardless of the time of exposure. 13,14,31 Cigarette smoking is a major factor disrupting the normal endothelial function and free radicals produced during this process destroy NO. These 2 factors greatly intensify the synthesis of the ET-1 precursor, preproET.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, cigarette smoking indirectly stimulates the secretion of ET-1. 13,14 Several studies have shown that the pancreas is probably the first organ where lesions caused by cigarette smoking are visible. 1,15 It has also been observed that there is a high correlation between exposure to tobacco smoke and the dysfunction of endocrine and exocrine of the pancreas in smokers.…”

mentioning

confidence: 99%

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The Effect of Smoking on Endothelin-1 in Patients With Chronic Pancreatitis

Śliwińska-Mossoń

Nabzdyk²,

Kokot³

et al. 2015

Applied Immunohistochemistry &Amp; Molecular Morphology

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The aim of this study is to prove the influence of tobacco smoking on the endothelin-1 (ET-1) level in the plasma and on the immunohistochemical localization in the pancreatic tissues. The blood was collected from 50 healthy individuals and 63 patients with chronic pancreatitis (CP). The ET-1 and cotinine concentrations in the plasma were estimated by ELISA. Samples of tissues of the normal pancreas and CP were verified histopathologically, and then ET-1 was localized by immunohistochemical staining using the monoclonal anti-human ET-1 antibody. The intensity of immunohistochemical reaction was calculated with the semiquantitative Digital Imaging Methodology. The study demonstrated a significant concentration of ET-1 in smoking healthy individuals and in patients with CP when compared with the nonsmoking population (P=0.003 and 0.0005, respectively). A significantly stronger immunohistochemical ET-1 reaction was observed in the tissue of smoking patients with CP than in the normal pancreatic tissue and of nonsmoking CP patients (P=0.001, 0.008, and 0.03, respectively). The presented data evidence that tobacco smoking has a direct effect on the endothelium, leading to an increased level of ET-1.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Effect of Smoking on Endothelin-1 in Patients With Chronic Pancreatitis

Śliwińska-Mossoń

Nabzdyk²,

Kokot³

et al. 2015

Applied Immunohistochemistry &Amp; Molecular Morphology

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show abstract

“…Several studies have shown that cigarette smoking can increase of insulin resistance. [33][34][35] Cigarette smoking was significantly more prevalent among males with diabetes (59.6 percent) than females with diabetes (0 percent; P<0.005). Also, estrogen is believed to exert a protective effect through the insulin/IGF axis by reducing serum IGF levels.…”

Section: Discussionmentioning

confidence: 99%

The Comparison of the Risk Factors and Clinical Manifestations of Proximal and Distal Colorectal Cancer

Kim

Choi

et al. 2008

Diseases of the Colon &Amp; Rectum

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“…Three patients in the present study had diabetes mellitus and 5 patients were smokers. It has been shown that microvascular vasoconstriction is augmented even in the prediabetic syndrome [17,18], and that smoking also could have a direct effect on insulin receptor affinity, thus leading to decreased peripheral insulin effectiveness [19].…”

Section: Vasoconstriction After Stentingmentioning

confidence: 99%