The Effect of Sleeve Gastrectomy on the Hormonal Profile of Patients with Polycystic Ovary Syndrome

Júnior, Agostinho de Sousa Machado; Ribeiro, Cláudio Barros Leal; Santa‐Cruz, Fernando; Sena, Brena F.; Figueiredo, José-Luiz; Ferraz, Álvaro Antônio Bandeira; Campos, Josemberg Marins

doi:10.1007/s11695-019-03854-z

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…Twelve months after LSG, the mean BMI, HOMA-IR level, TT level, and Ferriman-Gallwey score in patients with PCOS significantly decreased, and their menstrual cycles improved. The findings were supported by other studies, which have demonstrated that bariatric surgery could be an effective therapy for PCOS patients with obesity and could improve their clinical symptoms and metabolic dysfunctions [12,27].…”

Section: Discussionsupporting

confidence: 81%

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

Cai

Gao

et al. 2021

OBES SURG

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Objectives To investigate the changes in body fat distribution and predicting factors of these changes in polycystic ovary syndrome (PCOS) patients with obesity, after laparoscopic sleeve gastrectomy (LSG). Methods This study consecutively enrolled 153 patients with obesity aged 18-45 years (83 with PCOS and 70 control patients) who underwent LSG from May 2013 to September 2020 at the Department of Endocrinology, Shanghai Tenth People's Hospital, with a 12-month follow-up. Dual-energy X-ray absorptiometry (DEXA) was used to assess body fat distribution. ResultsThe percentage of fat mass loss in the visceral adipose tissue (VAT) region (55.08%) was more than that in any other body regions at 12 months post-surgery in the PCOS group yet insignificant. Homeostatic model assessment of insulin resistance (HOMA-IR) at baseline and Δ HOMA-IR were only negatively correlated with the variations in VAT mass and volume at 3 months post-surgery in the PCOS group. Logistic regression analysis showed that HOMA-IR <6.65 was an independent predictive factor for the changes in VAT mass and volume at 3 months post-surgery in the PCOS group. Conclusions In this study, the percentage loss of fat mass was greater in the VAT region than in any other body regions in all patients. The rate of VAT decrease in the PCOS group was higher than that in the control group yet insignificant. Compared with control patients, HOMA-IR at baseline was an independent risk factor for the changes in VAT mass and volume at 3 months postsurgery in patients with PCOS. Key Points• The percentage loss of fat mass was greater in the VAT region than in any other body regions in all patients.• The rate of VAT decrease in the PCOS group was higher than that in the control group yet insignificant.• HOMA-IR at baseline was an independent risk factor for the changes of VAT mass in patients with PCOS.

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Section: Discussionsupporting

confidence: 81%

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

Cai

Gao

et al. 2021

OBES SURG

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“…This finding is corroborated by Machado Júnior et al, who assessed the impact of vertical gastrectomy on the hormonal profile of obese women with PCOS, and found attractive results regarding the remission of the syndrome, showing an inversion in the gonadotropin secretion pattern in the postoperative period. 12 Thus, when a woman begins to lose weight, the tendency for improvement or even remission in the condition is evidenced. Research analyzing fertility in women after bariatric surgery has shown that weight loss has a beneficial effect on fertility and regularity of menstrual cycles in most studied patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Quality of Life in Women of Reproductive Age After Bariatric Surgery

Vieira

Cruz

Júnior

et al. 2020

Bariatric Surgical Practice and Patient Care

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Purpose: To evaluate the life quality of women of reproductive age in the late postoperative period of bariatric surgery, in addition to analyzing the physical and emotional difficulties related to the sexuality among these patients. Methods: A cross-sectional study, carried out in 2018 at Hospital das Clínicas, Federal University of Pernambuco, that analyzed the quality of life through the WHOQOL-Bref instrument, and the sexual experience of 49 women of reproductive age who had undergone bariatric surgery. Results: The mean age of the sample was 39.4 years. The mean weight before surgery was 116.8 kg, decreasing to 75.4 kg in the postoperative period. Sleeve gastrectomy was performed in 57.1% of the sample, and Roux-en-Y gastric bypass was performed in the remaining 42.9%. The mean follow-up time was 2.5 years. Infertility, depression, and polycystic ovary syndrome presented a statistically significant reduction in the postoperative period. In relation to the difficulties regarding sexual experience, the whole sample significantly improved after surgery. The great majority of patients positively classified their quality of life. Conclusion: Bariatric surgery leads to better quality of life in women of reproductive age, reducing comorbidities and improving their sexual experience in both physical and emotional scopes.

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“…Women with PCOS have hyperandrogenism and hyperinsulinemia with subsequent insulin resistance and infertility [43]. LSG is effective in treating PCOS, resulting not only in WL, but also significant improvement in the hormonal profile [43,44]. Significant decrease is observed as early as 3 months post-surgery in luteinizing hormone (LH) levels (7.2 vs. 4.5 mIU/mL), with inversion of LH/ FSH ratio (P = 0.008), as well as significant decrease in fasting insulin levels (24.4 mIU/mL vs. 9.0 mIU/mL) [44].…”

Section: Polycystic Ovarian Syndromementioning

confidence: 99%

Laparoscopic Sleeve Gastrectomy: Outcomes, Safety and Complications

Ansari¹

2021

Bariatric Surgery - From the Non-Surgical Approach to the Post-Surgery Individual Care

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Worldwide, the numbers of laparoscopic sleeve gastrectomy (LSG) performed grown exponentially over the last decade, because of its simplicity, safety profile and excellent outcomes in terms of durable weight loss and improvement of obesity-associated comorbidities. This chapter will provide a comprehensive review on the outcomes of LSG as a metabolic surgery. It appraises LSG\'s short, mid and long term weight loss outcomes, and compares these outcomes with those of other types of bariatric surgery. Then, a wider range of LSG outcomes are discussed, including a variety of comorbidities, clinical, biochemical and inflammatory parameters, while appraising the positive metabolic effects of LSG. The chapter also outlines the issues pertaining to LSG among a range of special populations such as adolescents, the elderly, renal transplant patients and others. The chapter concludes with a review of the safety and most common complications that may be encountered in the short term and long term, including surgical and nutritional complications, as well as mortality.

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The Effect of Sleeve Gastrectomy on the Hormonal Profile of Patients with Polycystic Ovary Syndrome

Cited by 11 publications

References 19 publications

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up

Evaluation of the Quality of Life in Women of Reproductive Age After Bariatric Surgery

Laparoscopic Sleeve Gastrectomy: Outcomes, Safety and Complications

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