The Effect of sium on the Onset Time of Rocuronium-Induced Neuromuscular Blockade in the Isolated Rat Phrenic Nerve-Hemidiaphragm

Koo, Eun Hye; Yoon, Suk Min; Hwang, Kyung Ho; Kim, Sung Yell

doi:10.4097/kjae.1999.37.3.467

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“…The effective dose (ED) 50 of pipecuronium changed in inverse proportion to the increase in magnesium concentration in animal studies [ 6 ]. Magnesium shortened the time to NMB onset mediated by rocuronium at an effective concentration (EC) of effective concentration (EC) 95 [ 7 ]. In addition, magnesium prolonged the duration of action of rocuronium [ 8 , 9 ].…”

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confidence: 99%

The effect of magnesium sulfate concentration on the effective concentration of rocuronium, and sugammadex-mediated reversal, in isolated left phrenic nerve hemi-diaphragm preparations from the rat

Cho

Sung

Choi

et al. 2018

Korean J Anesthesiol

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BackgroundPerioperative magnesium sulfate (MgSO4) is used for analgesic, anti-arrhythmic, and obstetric purposes. The effects of MgSO4 on the neuromuscular blockade (NMB) induced by rocuronium, and the sugammadex reversal thereof, have not been clearly quantified. We investigated the effect of various MgSO4 concentrations on the NMB by rocuronium, and sugammadex reversal, in isolated left phrenic nerve hemi-diaphragm (PNHD) preparations from the rat.MethodsRat PNHD preparations were randomly allocated to one of four groups varying in terms of MgSO4 concentration (1, 2, 3, and 4 mM, each n = 10, in Krebs solution). The train-of-four (TOF) and twitch height responses were recorded mechanomyographically. The preparations were treated with incrementally increasing doses of rocuronium and each group’s effective concentration (EC)50, EC90, and EC95 of rocuronium were calculated via nonlinear regression. Then, sugammadex was administered in doses equimolar to rocuronium. The recovery index, time to T1 height > 95% of control, and the time to a TOF ratio > 0.9 after sugammadex administration were measured.ResultsThe EC50, EC90, and EC95 of rocuronium fell significantly as the magnesium level increased. The EC50, EC90, and EC95 of rocuronium did not differ between the 3 and 4 mM groups. The recovery index, time to T1 height > 95% of control, and time to a TOF ratio > 0.9 after sugammadex administration did not differ among the four groups.ConclusionsIncreases in the magnesium concentration in rat PNHD preparations proportionally enhanced the NMB induced by rocuronium but did not affect reversal by equimolar amounts of sugammadex.

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