The Effect of Single-Dose Administration of Dexamethasone on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy

Abstract

Background:Postoperative pain is considered as a reason of patient’s delay in discharge and disability aggravation. Therefore, multimodal approaches have been suggested in order to mitigate pain and decrease postoperative side effects.Objectives:The aim of this study was to evaluate analgesic effect of a single dose injection of dexamethasone on reducing postoperative pain in laparoscopic cholecystectomy.Patients and Methods:In this double-blind, prospective study, 122 patients aged 18-60 years old, whom were selected for laparoscopic cholecystectomy, were classified into two case and control groups, and 61 patients were included in each group. The case (D) group underwent general anesthesia and a single- dose intravenous injection of dexamethasone. The Control (C) group received general anesthesia and intravenous injection of normal saline. Total dose of consumed meperidine and pain intensity during first 24 hours were evaluated in both groups.Results:No significant difference existed between two groups regarding age, sex, weight and operation time. Pain intensity in group D was significantly less than group C (P < 0.01) after two, six and 12 hoursof surgery. No significant difference existed in pain intensity between two groups at the beginning of and 24 hours after the surgery (P > 0.05). Meperidine consumption in group D was significantly less than group C (P < 0.05).Conclusions:Findings of present study showed that single dose of intravenous dexamethasone, led to less pain intensity and amounts of meperidine consumption, in comparison with placebo.

Study Of Efficacy Of Dexamethasone As Preemptive Analgesic In Patients Undergoing Total Abdominal Hysterectomy Under Spinal Anaesthesia: A Randomised Controlled Trial

“…The plasma half life of Dexamethasone is only about 6 hours (18) suggesting a persistent drug effect unrelated to plasma concentration. Our results are similar with the results of studies by Thangaswamy C at al (18) , Ahmadreza M et al (19) , Jose at al (20) . (21) studied the preemptive Effect of Dexamethasone (0.5 mg kg -1 ) on post-operative opioid requirement in patients who underwent gynecological surgeries.…”

“…Our results are in line with studies by Thangaswamy C et al (18) , Ahmadreza M et al (19) , Becky et al (21) . This is consistent with the fact that Dexamethasone has anti-inflammatory potency, with peak antiinflammatory effect at 12-24 hours and duration of action of 36-54 hours.…”

“…Our result match with Aissaoui Y et al (25) ,Thangaswamy C at al (18) , Ahmadreza M et al (19) , Becky et al (21) , Feroci et al (26) . There are studies by José at al (20) , Jun Koh et al (27) where they evaluated the timing of first rescue analgesic and total analgesic requirement for longer duration postoperatively.…”

Preoperative dexamethasone reduce postoperative pain and analgesic consumption in patient undergoing laparoscopic cholecystectomy

“…The timings of steroid administration is important to reducing postoperative pain, as initiation of its biological effect is one or two hour of its injection [14]. The dose of dexamethasone 8mg one hour before induction was based on previous reports showing a decrease in postoperative pain [9,15].…”

Effect of preoperative intravenous oxycodone administration on sufentanil consumption after retroperitoneal laparoscopic nephrectomy

“…Inappropriate management of postoperative pain extends the duration of hospital stay and may lead to undesirable adverse effects such as respiratory depression and thromboembolic complications [2]. As pre-emptive analgesia is defined as administering analgesics before the start of the painful stimulation, it may inhibit the development of hypersensitization and then result in less post-stimulus pain [3].…”