The effect of simvastatin on asymmetric dimethylarginine and flow-mediated vasodilation after optimizing the LDL level — A randomized, placebo-controlled study

Asymmetric dimethyl-arginine metabolism in a murine model of cigarette smoke-mediated lung inflammation

“…In a large, cross-sectional study in elderly men with hypercholesterolemia, Eid et al (2004) found an association between smoking and decreased circulating ADMA levels. Clearly establishing a link between smoking and lower ADMA levels in this study is complicated, however, by the high frequency of other cardiovascular disease risk factors and the potential impact of medications such as statins, which have been shown to lower ADMA levels (Lu et al, 2004;Vladimirova-Kitova and Deneva-Koycheva, 2012). It is likely that plasma ADMA concentrations are regulated by multiple factors that may differ between healthy and disease states.…”

A systematic review and meta-analysis on the effect of statins on plasma asymmetric dimethylarginine concentrations

“…The number of participants in these trials ranged from 53 to 650. The included studies were published between 2003 and 2012, and were conducted in Norway, Taiwan, the Netherlands, Bulgaria, Italy Turkey, New Zealand, China and Finland [22][23][24][25][26][27][28][29][30] . Statins (pravastatin, rosuvastatin, simvastatin, fluvastatin, and atorvastatin) were administered at doses from 10 to 80 mg/day.…”

“…Six trials were designed as parallel-group studies 22,25,27,[29][30][31] and 2 trials as cross-over studies 23,28 . One study 26 was a prospective follow-up trial conducted in 3 stages. Demographic and baseline parameters of the included studies are shown in Table 1.…”

Simvastatin treatment increases nitrite levels in obese women: Modulation by T−786C polymorphism of eNOS

“…Other regulator of eNOS is its endogenous inhibitor ADMA (asymmetric dimethylarginine). Some studies evaluated the effect of simvastatin on ADMA levels, however, none addressed this effect in obese women [30,31].…”