The effect of sildenafil on the elasticity of erythrocytes in homozygous sickle cell disease

Hagley, Abigail C; Younger-Coleman, Novie; Richards, A.A.; Nwokocha, Chukwuemeka R.; Pepple, D.J.

doi:10.4103/0019-5359.107024

Cited by 2 publications

(1 citation statement)

References 17 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increase in nitric monoxide bioavailability was suggested to improve RBC deformability ( Grau et al, 2013 ; Kuhn et al, 2017 ). However, increased concentrations of sildenafil impaired sickle RBC filterability ( Hagley et al, 2011 ). Typically, inhibition of cGMP-specific PDE type 5 (PDE-5) by sildenafil reduces the degradation of the second messenger cGMP to GMP and increases smooth muscles relaxation.…”

Section: Determinants Of Rbc Deformabilitymentioning

confidence: 99%

Squeezing for Life – Properties of Red Blood Cell Deformability

et al. 2018

View full text Add to dashboard Cite

Deformability is an essential feature of blood cells (RBCs) that enables them to travel through even the smallest capillaries of the human body. Deformability is a function of (i) structural elements of cytoskeletal proteins, (ii) processes controlling intracellular ion and water handling and (iii) membrane surface-to-volume ratio. All these factors may be altered in various forms of hereditary hemolytic anemia, such as sickle cell disease, thalassemia, hereditary spherocytosis and hereditary xerocytosis. Although mutations are known as the primary causes of these congenital anemias, little is known about the resulting secondary processes that affect RBC deformability (such as secondary changes in RBC hydration, membrane protein phosphorylation, and RBC vesiculation). These secondary processes could, however, play an important role in the premature removal of the aberrant RBCs by the spleen. Altered RBC deformability could contribute to disease pathophysiology in various disorders of the RBC. Here we review the current knowledge on RBC deformability in different forms of hereditary hemolytic anemia and describe secondary mechanisms involved in RBC deformability.

show abstract

Section: Determinants Of Rbc Deformabilitymentioning

confidence: 99%

Squeezing for Life – Properties of Red Blood Cell Deformability

et al. 2018

View full text Add to dashboard Cite

show abstract

Artocarpus Altilis (Breadfruit) could Reverse Myocardial Infarction Through the Normalization of the Oxygen Haemoglobin Dissociation Curve

Thomas

Anderson

Green

et al. 2022

CHAMC

View full text Add to dashboard Cite

Objective: Objective; The study was performed to assess if hematological mechanisms such as blood flow modulation, P50 and Oxygen haemoglobin dissociation are involved in Artocarpus altilis leaf extract amelioration of Isoproterenol-Induced Myocardial Damage in rats. Methods: Method; Twenty (20) adult male Sprague-Dawley rats were randomly divided into 5 groups. Group 1 served as the control, group 3 and 5 received 50 and 100 mg/kg Artocarpus altilis water extract respectively, after induced with Isoproterenol twice (85 mg/ kg) at a 24-hour period. Group 2 received 85 mg/kg isoproterenol only, while group 4 received 50 mg/kg Artocarpus altilis extract only for 6 days. The Hematological parameters were assessed using an automatic Coulter Counter, blood flow was assessed with the CODA machine using the tail cuff method, while blood viscosity measured at native hematocrit and the oxygen haemoglobin dissociation curves were assessed with the BioProfiler and Hemox Analyzer at the end of seven days. Results: Results; Artocarpus altilis treatment ameliorated the ISO induced increases in viscosity, increased the ISO induced decreases blood flow and influenced oxygen release through its effects on the P50 of the oxygen hemoglobin dissociation curve, AA treatment also reversed the ISO induced weight loss. Apart from the changes in MCH, MCV, there were no significant differences in hematological parameters. Conclusion: Conclusion; This study reported the effects of Artocarpus atilis on the improvement of oxygen availability, the reduction of blood viscosity, and the improvement of blood flow through its influence on endothelial functions, and NO availability. Our study futher highlights The usefulness of A.atilis, as having a beneficial cardiovascular and haematological outcome in experimental myocardial infarction, and as such, a potential drug discovery for diseases of cardiovascular & hematological involvementusefulness of A.atilis, as having a beneficial cardiovascular and haematological outcome in experimental myocardial infarction, and as such, a potential drug discovery for diseases of cardiovascular & hematological involvement

show abstract

The effect of sildenafil on the elasticity of erythrocytes in homozygous sickle cell disease

Abstract: The result of this study shows that sildenafil caused an initial increase in erythrocyte membrane elasticity in both HbSS and HbAA subjects, and this later decreased with increasing concentration of the drug possibly due to the dual effect of cyclic adenosine monophosphate (cAMP).

Cited by 2 publications

References 17 publications

Squeezing for Life – Properties of Red Blood Cell Deformability

Squeezing for Life – Properties of Red Blood Cell Deformability

Artocarpus Altilis (Breadfruit) could Reverse Myocardial Infarction Through the Normalization of the Oxygen Haemoglobin Dissociation Curve

Contact Info

Product

Resources

About