The effect of Sildenafil, a phosphodiesterase-5 inhibitor, on tendon healing: an experimental study in rat model of achilles tendon injury

Kurt, Vahap; Guner, Savaş; Kayacan, Ahmet Mesut; Eronat, Omer

doi:10.1007/s00402-023-05178-1

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2024

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“…[ 23 ] Interestingly, a study evaluating the effects of sildenafil, another phosphodiesterase inhibitor used in impotence treatment, on Achilles tendon healing reported positive histopathological effects. [ 32 ] In our study, while biomechanical effects were evident in the late period, positive differences were observed in all groups receiving papaverine treatment. From a histopathological perspective, the group that received local papaverine administration in the late period exhibited favorable outcomes.…”

Section: Discussionsupporting

confidence: 46%