The effect of short-term exercise on plasma leptin levels in patients with anorexia nervosa

Dostálová, I; Barták, V; Papežová, Hana; Nedvı́dková, J

doi:10.1016/j.metabol.2006.11.008

Cited by 14 publications

(21 citation statements)

References 44 publications

(64 reference statements)

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“…These results may indicate a disorder of the gut-hypothalamic-AT pathway in these patients in order to prevent energy losses. Hence, post-exercise decrease of leptin and increase of NPY are probably part of adaptive mechanisms leading to conservation of energy storage in BN [16,44]. …”

Section: Discussionmentioning

confidence: 99%

A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study

et al. 2011

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BackgroundNeuropeptide Y (NPY) is an important central orexigenic hormone predominantly produced by the hypothalamus, and recently found to be secreted in adipose tissue (AT). Acipimox (Aci) inhibits lipolysis in AT and reduces plasma glycerol and free fatty acid (FFA) levels. Exercise and Aci are enhancers of growth hormone (GH) and NPY secretion and exercise may alter leptin levels. We expect to find abnormal neuropeptidergic response in plasma and AT in patients with bulimia nervosa (BN). We hypothesize that Aci influences these peptides via a FFA-independent mechanism and that Aci inhibits lipolysis through a cyclic adenosine monophosphate (cAMP)-dependent pathway. Dysregulations of the AT-brain axis peptides might be involved in binge eating as is the case in BN.MethodsThe objective of this study was to determine the responses of plasma NPY, GH, leptin, FFA and glycerol levels to exercise in BN patients and healthy women (C) given the anti-lipolytic drug Aci or placebo. The secondary objective of this study was to compare the responses of extracellular glycerol levels and plasma glycerol levels to exercise alone or together with Aci administration in BN patients and C women. Extracellular glycerol was measured in vivo in subcutaneous (sc) abdominal AT using microdialysis. Eight BN and eight C women were recruited for this single-blind, randomized study. Aci or placebo was given 1 hour before the exercise (45 min, 2 W/kg of lean body mass [LBM]). NPY, GH, leptin, FFA, glycerol plasma and AT glycerol levels were measured using commercial kits.ResultsThe primary outcome of this study was that the exercise with Aci administration resulted in plasma NPY and GH increase (after a 45-minute exercise) and leptin (after a 90-minute post-exercise recovering phase) increased more in BN patients. The secondary outcomes of this study were that the exercise with Aci administration induced a higher decrease of extracellular glycerol in BN patients compared to the C group, while the exercise induced a higher increase of glycerol concentrations in sc abdominal AT of BN patients. Plasma glycerol levels decreased more in BN patients and plasma FFA levels were depressed in both groups after the exercise with Aci administration. The exercise induced similar increases in plasma NPY, GH, FFA and glycerol levels, and a similar decrease in the plasma leptin level in both groups.ConclusionsWe confirm the results of a single-blind, randomized, microdialysis study, i.e. that the Aci-induced elevation in plasma NPY and GH levels during the exercise is higher in BN patients and that Aci increased plasma leptin levels in the post-exercise recovering phase (90-minute) more in BN patients. The post-exercise rise (45-minute) in AT glycerol is much more attenuated by acute Aci treatment in BN patients. Simultaneously, we found facilitated turnover of plasma glycerol after the exercise together with Aci administration in BN. Our results support the hypotheses that Aci exerts an effect on the FFA-independent and cAMP-dependent mechanism.Trial Re...

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Section: Discussionmentioning

confidence: 99%

A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study

et al. 2011

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“…In most studies, mean serum adiponectin levels were found to be higher in anorexic patients than in normal-weight individuals and to be associated with an increase in insulin sensitivity [251][252][253][254]. The opposite was also reported, however, with a decrease in circulating adiponectin concentration in individuals with anorexia nervosa and bulimia nervosa relative to normal-weight controls [255].…”

Section: Eating Disordersmentioning

confidence: 99%

Adiponectin action from head to toe

Brochu-Gaudreau

Rehfeldt

Blouin

et al. 2009

Endocr

280

247

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Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its involvement in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus and atherosclerosis. Moreover, modulation of the circulating adiponectin concentration is observed in pathologies that are more or less obesity-related, such as cancer and rheumatoid arthritis. The wide distribution of adiponectin receptors in various organs and tissues suggests that adiponectin has pleiotropic effects on numerous physiological processes. Besides its well-known insulin-sensitizing, anti-inflammatory and antiatherosclerotic properties, accumulating evidence suggests that adiponectin may also have anticancer properties and be cardioprotective. A beneficial effect of adiponectin on female reproductive function was also suggested. Since adiponectin has numerous beneficial biological functions, its use as a therapeutic agent has been suggested. However, the use of adiponectin or its receptors as therapeutic targets is complicated by the presence of different adiponectin oligomeric isoforms and production sites, by multiple receptors with differing affinities for adiponectin isoforms, and by cell-type-specific effects in different tissues. In this review, we discuss the known and potential roles of adiponectin in various tissues and pathologies. The therapeutic promise of administration of adiponectin and the use of its circulating levels as a diagnostic biomarker are further discussed based on the latest experimental studies.

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“…Exercise alters some key hormones (eg, leptin, insulin, and ghrelin concentrations) that modulate energy balance [1][2][3][4][5][6]. These responses can occur quickly, even after a single exercise bout of sufficient intensity and/or duration [2,5,[7][8][9]. Prolonged exercise (≥60 minutes) with a considerable energy expenditure has been shown to lower leptin (measured 48 hours postexercise) and insulin (12-24 hours postexercise) concentrations [8,9], but shorter exercise bouts (b60 minutes) usually do not [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of short-term exercise and energy surplus on hormones related to regulation of energy balance

2008

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Energy surplus raises circulating concentrations of leptin and insulin while lowering plasma ghrelin. Exercise has the opposite effects. The purpose of this study was to determine whether exercise counters the hormonal effects of energy surplus independent of changes in energy balance. To do that, we assessed plasma concentrations of leptin, insulin, and ghrelin at baseline, after overfeeding, and after overfeeding plus exercise. Baseline (B) leptin and insulin concentrations and ghrelin area under the curve were measured during an oral glucose challenge in 9 healthy, active subjects (6 male, 3 female) after 2 days in energy balance without exercise. Measurements were repeated after subjects were overfed by +3213 ± 849 kJ/d for 3 more sedentary days (OF). In the third condition, the same net energy surplus (+3125 ± 933 kJ/d) was generated for 24 hours by doubling the overfeeding (+6284 ± 1669 kJ/d) and countering it with a bout of exercise (expenditure = 3063 ± 803 kJ); and measurements were made the next day (OF + EX). Compared with B, leptin went up (5.8 ± 8.2 to 7.6 ± 10.6 ng/mL) after OF, but was not significantly higher after OF + EX (7.1 ± 10.2 ng/mL). Compared with B, insulin was +36% and +43% higher after OF and OF + EX, respectively. In contrast, ghrelin area under the curve did not change after OF but was significantly lower (−14%) than B or OF after OF + EX (indicating greater suppression). These data suggest that the effect of short-term exercise on fasting leptin and insulin depends on energy balance but the ghrelin response may be partially mediated by effects of exercise independent of energy balance..

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The effect of short-term exercise on plasma leptin levels in patients with anorexia nervosa

Cited by 14 publications

References 44 publications

A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study

A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study

Adiponectin action from head to toe

Effects of short-term exercise and energy surplus on hormones related to regulation of energy balance

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