The Effect of Short‐Term Administration of Minocycline HCl on Gingival Inflammation and Subgingival Microflora,

Abstract

The purpose of this investigation was to determine the efficacy of minocycline hydrochloride in the management of subgingival microorganisms and periodontal disease. In a double‐blind, split‐mouth study, minocycline or placebo was administered systemically for 7 days to 26 adults with moderate‐to‐severe periodontitis. Four study groups were examined: (i) minocycline‐scaled, (ii) minocycline‐unscaled, (iii) placebo‐scaled, and (iv) placebo‐unscaled. The minocycline‐scaled group responded most favorably, with improved gingival health for at least 49 days and with marked reductions in total bacterial counts and proportions of spirochetes for at least 70 days (termination of the study). Minocycline administration with no periodontal scaling and root planing also resulted in major, long‐lasting shifts in the subgingival microflora. Scaling alone was least effective in changing the microflora. The data indicated that minocycline may be a useful adjunct in the treatment of periodontal disease. Further studies are needed, however, to determine the long‐term effect of minocycline therapy on the periodontal attachment level.

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

“…The latter finding suggests that there is no significant difference in PD reduction between mechanical treatment alone and mechanical treatment combined with doxycycline. These findings are consistent with the findings of several previous studies in which no significant difference could be found between mechanical treatment combined with tetracycline or minocycline and mechanical treatment alone (10,11,16). However, contrary findings have also been reported.…”

“…Many studies on clinical effects of both systemic and local tetracyclines have been performed. In some of these studies, tetracyclines made no statistically significant difference on probing depths and clinical attachment levels (10,11,(14)(15)(16)(17)(18)(19) while in others successful clinical results were obtained by tetracycline and minocycline treatments (20)(21)(22)(23)(24)(25)(26)(27)(28). These studies evaluated only systemic or local antibiotic treatments with or without mechanical periodontal treatment.…”

Effect of Systemic Doxycyline Administration on the Subgingival Microbial Flora: A Dark-field Microscopy Study.

“…In particular, extensive studies have been conducted with metranidazole and tetracyclines [7,[9][10][11][12]22,23]. Due to their high concentration in gingival crevicular fluid, their ability to bind to bone and inhibit tissue collagenase, tetracyclines are the most recommended group of antibiotics for treatment of periodontal disease [13,24,25].…”

“…Systemically administered antibacterial agents are being tried with increasing frequency for the clinical management of periodontal problems [7,[9][10][11][12]. Tetracyclines are one group of antibiotics that have been used widely in the treatment of periodontal disease [7,9,11,12].…”

Adsorption of Antibiotic TA to Dental Hard Tissues

“…Although systemic administration of antibiotics has been shown to be of value in the control of periodontal diseases, these treatments are mainly beneficial as adjuvants to mechanical debridement (Ciancio et al, 1982;Lindhe et al, 1983;Lundstrom et al, 1984). Anti-bacterial activity alone cannot predict the efficacy of a drug as an anti-plaque agent (Gjermo et al, 1970).…”