The Effect of Short-Contact Topical Tretinoin Therapy for Foot Ulcers in Patients With Diabetes

Tom, Wynnis L.; Peng, David H.; Allaei, Atabak; Hsu, Daniel P.; Hata, Tissa

doi:10.1001/archderm.141.11.1373

Cited by 39 publications

(22 citation statements)

References 19 publications

(34 reference statements)

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“…A similar randomized controlled trial with “short‐contact” topical tretinoin by Tom et al for patients with diabetic foot ulcers showed significantly decreased ulcer area and depth compared with placebo treatment over the 16‐week study period. This study was completed by 22 patients …”

Section: Evidence For Use Of Vitamin a On Chronic Woundsmentioning

confidence: 99%

Vitamin A and Wound Healing

et al. 2019

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Vitamin A is a general term for retinoids. Vitamin A deficiency leads to a variety of cutaneous manifestations. It also functions as a hormone through retinoic acid receptors altering the activity of multiple cell lines. Pancreatic vitamin A levels are critical for retinoid signaling and normal pancreatic control of glucose. Vitamin A deficiency is more common during infection, and supplementation reduces severe morbidity and mortality from infectious diseases. Vitamin A modulates activities at the cellular level and, via its interrelationship with hormones such as thyroid, insulin, and corticosteroids, has diffuse metabolic effects on the body. It plays an important role in all stages of wound healing. Vitamin A is known for its ability to stimulate epithelial growth, fibroblasts, granulation tissue, angiogenesis, collagen synthesis, epithelialization, and fibroplasia. Local (topical) and systemic supplementation with vitamin A has been proven to increase dermal collagen deposition. There are numerous animal studies and limited human studies regarding physiologic effect of vitamin A on acute or chronic wounds via systemic or topical administration. The most common use of vitamin A supplementation is to offset steroids' effect. When considering supplementation, the potential benefits must be weighed against the risk of harm. Vitamin A toxicity can be critical and even result in death. The evidence for supplementation with vitamin A is currently limited to expert opinion and is not backed up by rigorous trials. There is an acute need for therapeutic trials with vitamin A supplementations. (Nutr Clin Pract. 2019;34:839-849)

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Section: Evidence For Use Of Vitamin a On Chronic Woundsmentioning

confidence: 99%

Vitamin A and Wound Healing

et al. 2019

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“…37,38 The current therapies for chronic wounds include a new generation of dressings (impregnated gauzes, films, hydrogels and hydrocolloids, alginates, foams), topical negative pressure, 39 or bioengineered skin substitutes (Integra, Alloderm, Biobrane, TranCyte, Oasis, Orcel, Epicel, Dermagraft, and Apligraft 37,40 ). Other adjuvant treatments are hyperbaric oxygen therapy, 41 tretinoin cream, 42 and the oral administration of pentoxifylline. 43 Many solutions have been developed in the last 20 years, but none can be applied to every chronic wound and often only surgery is the resolution.…”

Section: Nonhealing Wound Pathogenesismentioning

confidence: 99%

Adipose-Derived Stem Cells for Wound Healing Applications

Cherubino¹,

Rubin²,

Miljković³

et al. 2011

Annals of Plastic Surgery

151

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Nonhealing wounds remain a significant challenge for plastic surgeons. More than 600,000 people suffer from venous ulcers and 1.5 to 3 million people are being treated for pressure sores every year in the United States. The use of tissue engineering techniques such as stem-cell therapy and gene therapy to improve wound healing is a promising strategy. Adipose tissue represents a source of cells that may be able to enhance wound healing. Adipose-derived stem cells (ASCs) are adult stem cells that are easily harvested and of great interest for plastic surgeons. Specifically, ASCs secrete angiogenic growth factors that can induce tissue regeneration. This review describes innovative research strategies using ASCs therapies for treatment of chronic, nonhealing wounds.

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“…Paquette et al [11] have reported that shortcontact daily application of tretinoin topically improved the healing in five chronic leg ulcers. Tom et al [12] also investigated the efficacy and safety of short-contact topical tretinoin in a randomised control study of 24 patients with diabetic foot ulcers and concluded that short-contact topical tretinoin reduced both the surface area and depth of the ulcers.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of short-contact topical tretinoin in promoting wound healing in db/db mice

Toyama

Ohura

Kurita

et al. 2006

Scandinavian Journal of Plastic and Reconstructive Surgery and

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We have investigated the effects of short-contact topical application of tretinoin using 16 male db/db mice by creating two full-thickness wounds on the skin of the back. A 0.1% tretinoin aqueous gel was applied to one wound for five minutes daily for five successive days while only aqueous gel was applied to the other (control). The mean (SD) percentage surface area unhealed before and after treatment were 0.88 (0.3) and 0.64 (0.15). In tretinoin-treated mice and non-treated mice (controls), the mean (SD) thicknesses of granulation were 1.383 (697) micro m and 683 (413) micro m, the density of capillary vessels in granulation was 12.2 (5.5)% and 5.7 (3.9)%, respectively. Differences between the two groups were significant for each variable. Wound healing was accelerated with short-contact topical application of tretinoin in db/db mice.

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The Effect of Short-Contact Topical Tretinoin Therapy for Foot Ulcers in Patients With Diabetes

Cited by 39 publications

References 19 publications

Vitamin A and Wound Healing

Vitamin A and Wound Healing

Adipose-Derived Stem Cells for Wound Healing Applications

Effectiveness of short-contact topical tretinoin in promoting wound healing in db/db mice

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