The effect of shear and extensional viscosities on atomization of Newtonian and non-Newtonian fluids in ultrasonic inhaler

Broniarz-Press, L.; Sosnowski, Tomasz R.; Matuszak, Magdalena; Ochowiak, Marek; Jabłczyńska, Katarzyna

doi:10.1016/j.ijpharm.2015.02.065

Cited by 27 publications

(15 citation statements)

References 37 publications

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“…greater than 6 cP). [23,25,55,65] For less viscous liquids, an inverse relationship to the respirable output occurs. And comparing liquids with decreasing surface tension, peak values for VMDs outbalance the trough values of total output resulting in an optimal respirable output from ultrasonic nebulizers concurring with droplet size patterns generated.…”

Section: Ultrasonic Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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Objectives In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. Key findings Nebulization is the transformation of bulk liquids into droplets. For inhalation therapy, nebulizers are widely used to aerosolize aqueous systems, such as solutions and suspensions. The interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations plays a significant role in the performance of aerosol generation appropriate for pulmonary delivery. Certain types of nebulizers have consistently presented temperature increase during the nebulization event. Therefore, careful consideration should be given when evaluating thermo-labile drugs, such as protein therapeutics. We also present the general approaches for characterization of nebulizer formulations. Summary In conclusion, the interplay between the dosage form (i.e. aqueous systems) and the specific type of device for aerosol generation determines the effectiveness of drug delivery in nebulization therapies, thus requiring extensive understanding and characterization.

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Section: Ultrasonic Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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“…Complex fluids are mixtures that have a coexistence between two or multiphases, which are common in our society and industry [102][103][104]. Many complex fluids are non-Newtonian fluid, whose characteristics of breakup and atomization are unusual [82,[105][106][107].…”

Section: Complex Fluidsmentioning

confidence: 99%

Breakup Morphology and Mechanisms of Liquid Atomization

Zhao¹,

Liu²

2020

Environmental Impact of Aviation and Sustainable Solutions

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Fuel atomization, the transformation of bulk liquid into sprays, is of importance in jet engines. In this chapter, we will introduce the latest research advances on breakup morphology and mechanism of liquid atomization. On primary atomization, based on the morphological difference, the twin-fluid atomization could be classified into different regimes. The influence of Kelvin-Helmholtz and Rayleigh-Taylor instability on breakup morphology and fragment size is great and nonmonotonic. On secondary atomization, Rayleigh-Taylor instability is considered as the main driving mechanism in different bag-breakup modes; for higher Weber number, it will be in concurrence with the shear instability. Based on ligamentmediated spray formation model, ligament breakup is found to be well represented by the gamma distributions. Atomization of complex fluids has special characteristics and mechanisms. There are also a lot of research advances recently in this field.

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“…Nebulizers which spray liquid medicines (originally being a solution or suspension), utilize compressed air, ultrasonics or vibrating mesh technology to produce mist of droplets within the micrometric size range. The quality of aerosol mist often depends on the physicochemical properties of nebulized drugs, mainly, the viscosity, surface tension and ionic strength [4][5][6]. The main advantage of nebulizers is that they are used during normal (tidal) breathing, without special inhalation maneuvers, which make them suitable also for toddlers or people with disabilities.…”

Section: Fig 2 a Scheme Of Inhalation As A Route Of Drug Deliverymentioning

confidence: 99%