The effect of sevoflurane anesthesia on the corneal endothel

In this study, we aimed to evaluate the mean changes in the corneal endothelial cells and pachymetry values of patients who underwent general anesthesia with sevoflurane with N2O or O2. Materials and Methods: Forty eyes of 40 patients who had extraocular surgery under general anesthesia were included in this prospective study. The patients were divided into two groups as the O2 and N2O groups, for which %50 O2 (total flow rate; 2 L/min in O2-air mixture) and %50 O2 (total flow rate; 2 L/min in O2-N2O mixture) were used, respectively. The duration of the surgery was recorded. The CD (cell density), CV (cell variation), Hex (hexagonality rate) and pachymetric specular microscopy results were evaluated before surgery, and at the first and fourth weeks after surgery. Results: The surgical duration and demographic data of the groups were similar, and there was no statistically significant difference between the two groups. The value of CV was 26±2 cell/mm2 for the O2 group and 30 cell/mm2 for the N2O group at the first week. There was a statistically significant increase in the N2O group values, compared to the preoperative values (p=0.008). The Hex value was 52±10% for the O2 group and 62±11% for the N2O group at the first postoperative week, and there was a statistically significant increase in the N2O group values in comparison to the preoperative values (p=0.007). There was no significant difference between the two groups in terms of CD, CV, Hex, and pachymetry at other times. Discussion and Conclusion: Statistically significant change was observed at the first postoperative week in the corneal variation and hexagonality rate values of the pediatric patients who underwent general anesthesia with nitrous oxide. More studies need to be done for further assessments.

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“…The patients in this study were younger and had normal body mass index. (12). The corneal endothelial cells are not regenerative.…”

Section: Discussionmentioning

confidence: 99%

Does Nitrous Oxide Affect the Corneal Endothelium? Prospective Randomized Study in Pediatric Patients

Özkan

Akbaş

Polat

et al. 2017

Anadolu Kliniği Tıp Bilimleri Dergisi

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“…This endothelial dysfunction (ED) is characterized by a modification of the balance between vasodilator, anti-mitotic, anti-thrombogenic and anti-adhesive substances, in favor of those known as vasoconstrictors, pro thrombogenes, pro adhesives and proliferatives [7] [8] [9]. Some of therapeutic technics such as spinal anesthesia (SA) as well as conditions of a medical or surgical nature, in varying degrees of their development can be responsible for ED [10] [11] [12] [13]. Spinal anesthesia (SA) is an anesthesia technic that involves the intra thecal injection of locoregional anesthetic [14] [15].…”

Section: Introductionmentioning

confidence: 99%

Is There a Relationship between Endotheline-1, Vascular Cell Adhesion Molecule-1 and the Arterial Hypotension Observed during Spinal Anesthesia?

Essone¹,

Pascal²,

Nkhilli³

et al. 2021

JBM

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Introduction: The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. Objective: To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after SA. Population and Methods: The study concerned 40 people who were to benefit from a programmed herniorrhaphy under SA and 40 controls (SA − ). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from SA + one hour before (H0), then 15 minutes after the SA (H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p < 5%). Results: CmET-1 and CmVCAM-1 of SA − were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in SA + at H0 and H15. In SA + , at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In SA − , a negative correlation existed between CmET-1 and Cm-VCAM-1

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The effect of sevoflurane anesthesia on the corneal endothel

Cited by 2 publications

References 12 publications

Does Nitrous Oxide Affect the Corneal Endothelium? Prospective Randomized Study in Pediatric Patients

Does Nitrous Oxide Affect the Corneal Endothelium? Prospective Randomized Study in Pediatric Patients

Is There a Relationship between Endotheline-1, Vascular Cell Adhesion Molecule-1 and the Arterial Hypotension Observed during Spinal Anesthesia?

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