The Effect of Severe Zinc Deficiency on Activity of Intestinal Disaccharidases and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in the Rat

Gebhard, Roger L.; Karouani, Rachida; Prigge, William F.; McClain, Craig J.

doi:10.1093/jn/113.4.855

Cited by 58 publications

(32 citation statements)

References 18 publications

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“…It is well established that dextrin is easily digested to glucose with amylase and maltase. The decreased amylase in pancreatic juice (25) and maltase activity in the intestine (23,26) may not prevent the preference for dextrin diet in rats fed a Zn-deficient diet.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Horikawa

Uehara

Matsuda

et al. 2008

J Nutr Sci Vitaminol

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Summary This study examined whether the chain length of glucose in the diet could affect the selection of foods by Zn-adequate and Zn-deficient rats. Dextrin, maltose and glucose were used as sources of carbohydrate in the diet and the selection patterns of the rats were analyzed for 28 d by a 3-choice selection. Diets provided as a set of three either Zn-adequate or Zn-deficient diets were rotated daily. The Zn-adequate control rats selected widely from the three diets throughout the 28 d. In contrast, rats fed a Zn-deficient diet selected exclusively and continuously the dextrin diet or dextrin and glucose diets from the three diets over the experimental periods. The average daily total food intakes of rats fed a Zn-deficient diet were very significantly decreased. The selections of dextrin, maltose and glucose diets in the 3-choice methods of the control rats were 5.7 Ϯ 1.6 b , 5.8 Ϯ 2.0 b and 2.7 Ϯ 0.9 a g/ d, respectively ( p Ͻ 0.05), and those of the Zn-deficient rats were 6.4 Ϯ 2.5 c , 0.8 Ϯ 1.3 a and 2.6 Ϯ 1.4 b g/d, respectively ( p Ͻ 0.05). The ratios of the selected maltose-diet in the Zn-adequate control and the Zn-deficient rats were 40.8 Ϯ 13.8 and 9.0 Ϯ 15.6%, respectively ( p Ͻ 0.01) and those of the dextrin-diet were 40.3 Ϯ 11.4 and 63.0 Ϯ 22.3%, respectively ( p Ͻ 0.05). The decreased preference for the maltose-diet in the Zn-deficient rats may reflect the increased selection of the dextrin-diet.

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Section: Discussionmentioning

confidence: 99%

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Horikawa

Uehara

Matsuda

et al. 2008

J Nutr Sci Vitaminol

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“…Diarrhea leads to increased intestinal loss and malnutrition with micronutrients, including zinc. This loss can be corrected by oral zinc supplementation, which may improve the absorption of water and electrolytes by the intestine [52,63,108], lead to a faster regeneration of the gut epithelium [12], and increase the levels of enterocyte brush-border enzymes [49,106]. Finally, the loss of zinc may negatively affect immune function, which can be antagonized by zinc supplementation to improve the clearance of bacterial pathogens from the intestine [146].…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases

Overbeck

Rink

Haase

2008

Arch. Immunol. Ther. Exp.

179

124

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Zinc is required for multiple cellular tasks, and especially the immune system depends on a sufficient availability of this essential trace element. During the last decades, many studies attempted to affect the outcome of various diseases by zinc supplementation. These efforts either aimed at supporting immunity by zinc administration or at correcting a loss of zinc secondary to the disease to restore the zinc-dependent functions of the immune system. This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination. Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory infection, and leishmaniasis seems beneficial. In contrast, the results for the common cold and malaria are still not conclusive, and zinc was ineffective in most vaccination and rheumatoid arthritis studies. For AIDS and type 1 diabetes, zinc supplementation may even be a risk factor for increased mortality or deterioration of the glucose metabolism, respectively. In these cases, zinc supplementation should be used with care and limited to clearly zinc-deficient individuals.

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“…Reduced intestinal disaccharidases activities (17) and abnormal lipid absorption have been reported (18). Thus, maldigestion and malabsorption of nutrients may, at least in part, account for the diarrhea and malnutrition seen in zinc deficiency.…”

Section: Resultsmentioning

confidence: 97%

The Effects of Severe Zinc Deficiency on Intestinal Permeability: An Ultrastructural Study

Moran

Lewis

1985

Pediatr Res

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ABSTRACT. Evidence suggests that intestinal transport of water and electrolytes may be altered in zinc deficiency. We examined the structural features of intestinal epithelial cells of zinc-deficient rats using electron microscopy and assessed the integrity of the junctional complexes using a heavy metal tracer, lanthanum hydroxide. The absorptive cells, as well as Paneth cells and chromaffin cells, were not found to have ultrastructural changes of a consistent nature in zinc deficiency. Moreover, the integrity of the junctional complexes was found to be preserved. These findings suggest that the abnormalities in intestinal transport previously reported are not secondary to increased tight junction permeability in zinc deficiency.

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The Effect of Severe Zinc Deficiency on Activity of Intestinal Disaccharidases and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in the Rat

Cited by 58 publications

References 18 publications

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases

The Effects of Severe Zinc Deficiency on Intestinal Permeability: An Ultrastructural Study

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