The effect of sesame, canola, and sesame‐canola oils on cardiometabolic risk factors in overweight adults: a three‐way randomized triple‐blind crossover clinical trial

Moghtaderi, Fatemeh; Amiri, Mojgan; Raeisi‐Dehkordi, Hamidreza; Zimorovat, Alireza; Mohyadini, Matin; Salehi‐Abargouei, Amin

doi:10.1002/ptr.7381

Cited by 5 publications

(5 citation statements)

References 67 publications

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“…In contrary, a very recent study by Moghtaderi et al . [ 163 ] did not prove positive effect of sesame oil on BP; however, in this study the exact amount of consumed oil in patients’ food was not specified, only the time of consumption (9 weeks). Positive effect of sesame oil (or sesamin) consumption on hypertension and endothelial function was confirmed in a clinical study of Karatzi et al .…”

Section: The Effect Of Sesame Oil On Cardiovascular Health and Diseasesmentioning

confidence: 82%

Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease

Kindernay,

Ferenczyová,

Farkašová

et al. 2023

Rev. Cardiovasc. Med.

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A variety of vegetable and fruit derived food oils are considered beneficial for human health due to their content of functional components including their positive effects in cardiovascular system. In addition to the favorable ratio of unsaturated versus saturated fatty acids, some of these oils include also other health beneficial compounds such as vitamins, minerals, pigments, enzymes and phenolic compounds. Particularly polyphenols have been documented to exert numerous positive effects in cardiovascular system including their anti-hypertensive, anti-atherogenic as well as cardio- and vasculo- protective effects in subjects suffering from various cardiovascular and cardiometabolic diseases, likely via their antioxidant, anti-inflammatory, anti-coagulant, anti-proliferative and anti-diabetic properties. However, it has not been proven so far whether the positive cardiovascular effects of polyphenol-rich food oils are, and to what measure, attributed to their phenolic content. Thus, the current review aims to summarize the main cardiovascular effects of major polyphenol-rich food oils including olive, flaxseed, soybean, sesame and coconut oils, and to uncover the role of their phenolic compounds in these effects.

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Section: The Effect Of Sesame Oil On Cardiovascular Health and Diseasesmentioning

confidence: 82%

Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease

Kindernay,

Ferenczyová,

Farkašová

et al. 2023

Rev. Cardiovasc. Med.

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“…In healthy subjects, no consistent effects on blood glucose levels, lipid profiles, and anthropometric measures were observed among participants provided sesame seed, oil, flour, or sesamin 47,48,60,61,63,85 . Similar inconsistencies in these outcomes were observed for hypercholesterolemic/hyperlipidemic, overweight, and hypertensive subjects 66–68,70–72,88–90 . Furthermore, in hypertensive individuals, overall effects on blood pressure were inconsistent.…”

Section: Methodsmentioning

confidence: 91%

Sesame

Singletary¹

2022

Nutr Today

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Sesame (Sesamum indicum L.) is an annual plant whose seeds are purported to be one of the oldest oilseeds used by humans. Although originating in Africa and India, this plant currently is cultivated in diverse regions worldwide from semiarid tropics to temperate areas. This edible seed oil has many routine and diverse uses in food preparation and cooking, and the dehulled seed is included in the preparation of numerous food products, condiments, and confectionaries, imparting a distinctive savory, nutty, roasted flavor. Sesame has a long history of use in traditional medicines for treatment of wounds, asthma, blurred vision, abdominal pain and ulcers, toothaches and gum disease, and migraine, to name a few. More recently, sesame constituents have demonstrated antioxidant and anti-inflammatory properties that may alleviate conditions such as atherosclerosis, diabetes, hypertension, and pain. The current narrative summarizes human studies evaluating sesame seeds, oil, and constituents for improving diverse human disorders, and provides suggestions for future research. Nutr Today 2022;57(5):271-287 S esame (Sesamum indicum L., family Pedaliaceae), also known as sesamum, gingelly, til, goma, ajonjoli, and benniseed, is an annual plant (Figure 1). The seeds are purported to be one of the oldest oilseeds used by humans. The seed colors of this plant vary considerably including white, yellow, gray, brown, and black, depending on the variety and strain of S indicum. Black sesame seeds and white sesame seeds are the most available worldwide.Although the chemical differences among the various colored sesame seeds are not well characterized, it has been reported that the contents of indole-3-carboxylic acid, hesperidin, 2-methoxycinnamic acid, vitamin B2, and hyoscyamine are significantly higher in black seeds compared with white seeds. However, at least for sesame lignans, seed color and content of these bioactives are unrelated. 1,2 Although apparently originating in Africa and India, this plant is currently cultivated in diverse regions worldwide from semiarid tropics to temperate areas, and India, China, Tanzania, Sudan, and Myanmar are considered the major producers. Because of the high content of oil, sesame seed is called the queen of oilseeds. Its major use is the production of a notably oxidative rancidity-resistant oil. This oil has numerous uses such as a solvent, a hydrophobic vehicle for drug delivery, and a skin softener, and in the preparation of soaps and margarines. [2][3][4][5][6][7] In cosmetics, it can function as a binder, emulsifier, and viscosity-increasing agent. 8 As an edible seed oil, it has many routine and diverse uses in food preparation. It has widespread use globally in salads, and in Asia, the seed and oil are routinely used in cooking. Some Europeans substitute it for olive oil in cooking. The dehulled seed is included in the preparation of numerous food products, condiments, and confectionaries, imparting a distinctive savory, nutty, roasted flavor. For example, besides being sprinkled on ...

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“…Given the existence of evidence about the effectiveness of sesame in glucose metabolism, some RCTs similar to our overall pooled results found that sesame may improve glycemic indices (Aslam et al, 2019; Ghoreishi et al, 2022; Mohammad Shahi et al, 2017). While, others proposed that sesame could not be a useful adjuvant therapy in controlling glycemic parameters (Bahadoran et al, 2015; Moghtaderi et al, 2022). The variability of results in these studies may be attributed to the differences in study design, individual characteristics, sesame dose, and intervention duration.…”

Section: Discussionmentioning

confidence: 99%

“…While, others proposed that sesame could not be a useful adjuvant therapy in controlling glycemic parameters (Bahadoran et al, 2015;Moghtaderi et al, 2022). The variability of results in these studies may be attributed to the differences in study design, individual characteristics, sesame dose, and intervention duration.…”

Section: Discussionmentioning

confidence: 99%

Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

Ramírez‐Coronel

Alhilali

Ahmed

et al. 2023

Phytotherapy Research

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Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta‐analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control in patients with T2D. Published literature was retrieved and screened from PubMed, Scopus, ISI Web of Science, and the Cochrane Library up to December 2022. Outcome measures included fasting blood sugar (FBS) concentrations, fasting insulin levels, and hemoglobin A1c (HbA1c) percentage. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight clinical trials (395 participants) were eligible for meta‐analyses. Overall, sesame consumption significantly reduced serum FBS (WMD: −28.61 mg/dL, 95% CI: −36.07 to −21.16, p˂0.001; I2 = 98.3%) and HbA1c percentage (WMD: −0.99%, 95% CI: −1.22 to −0.76, p ≤ 0.001; I2 = 65.1%) in patients with T2D. However, sesame consumption did not significantly influence fasting insulin levels (Hedges's: 2.29, 95% CI: −0.06 to 4.63, p = 0.06; I2 = 98.1%). In summary, the current meta‐analysis showed a promising effect of sesame consumption on glycemic control through reducing FBS and HbA1c, yet additional prospective studies are recommended, using higher doses and longer intervention period, to confirm the impact of sesame consumption on insulin levels in T2D patients.

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The effect of sesame, canola, and sesame‐canola oils on cardiometabolic risk factors in overweight adults: a three‐way randomized triple‐blind crossover clinical trial

Cited by 5 publications

References 67 publications

Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease

Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health and Disease

Sesame

Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

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