The Effect of Sertraline Add-On to Brief Dynamic Psychotherapy for the Treatment of Postpartum Depression

Bloch, Miki; Meiboom, Hadas; Lorberblatt, Merona; Bluvstein, Irit; Aharonov, Inbar; Schreiber, Shaul

doi:10.4088/jcp.11m07117

Cited by 60 publications

(73 citation statements)

References 36 publications

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“…Sertraline in combination with brief dynamic psychotherapy was not better than placebo combined with psychotherapy in causing significant remission in therapeutic randomized controlled trial (Bloch et al 2012).Fluoxetine along with counselling was found to be effective in reducing depression levels when compared with placebo (Appleby et al 1997). Nevertheless, patients receiving 6 sessions of counselling improved most in the study.…”

Section: Selective Serotonin Reuptake Inhibitors (Ssri):-mentioning

confidence: 80%

Management of Peripartum Depression: Better, Prevent Than Treat!.

Kumar¹,

KuradyBairy²

2018

IJAR

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Section: Selective Serotonin Reuptake Inhibitors (Ssri):-mentioning

confidence: 80%

Management of Peripartum Depression: Better, Prevent Than Treat!.

Kumar¹,

KuradyBairy²

2018

IJAR

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“…160 The main analysis of all patients provided evidence of no statistically significant difference between add-on sertraline (70%) and placebo (55%) in response rates (>50% reduction in either the MADRS or EPDS scores). The post-hoc analysis of the high depression severity subgroup also found no statistically significant difference in response rate (t=1.05; P=0.31).…”

Section: Severity Of Symptomsmentioning

confidence: 90%

“…We found three small medium risk of bias RCTs 156,160,166 and one small, high risk of bias observational study 73 that compared combining pharmacologic treatments with nonpharmacological treatments and comparing them with nonpharmacological treatments alone. All of the studies focused on the postpartum period only and reported on depression symptoms.…”

Section: Maternal Outcomesmentioning

confidence: 99%

“…There were six observational studies of treatment during pregnancy 42,45,59,76,81,156 and three RCTs of treatment during the postpartum period that met this best evidence criteria. 97,160,166 Among those, only one randomized control of women with postpartum depression evaluated the effects of depression severity 160 and four studies evaluated the effects of treatment duration. 42,45,76,166 Exposure During Pregnancy Duration of Treatment Preterm birth.…”

Section: Detailed Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of Depression During Pregnancy and the Postpartum Period

2013

PsycEXTRA Dataset

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“…The treatment had very good effect (100% of participants had recovered from depression at follow-up), but there was no differences to the comparison treatment (family therapy, in where 81% no longer were depressed). Using the same manual, Bloch et al (2012) found no differences between dynamic therapy + antidepressants compared to dynamic therapy + placebo in a sample of participants with postpartum depression. However, within-group effects were very large on the primary outcome measure of depression (d = 3.78 and d = 2.56 for dynamic therapy plus antidepressants and placebo, respectively).…”

Section: Experiential Dynamic Therapymentioning

confidence: 90%

Treating depression and its comorbidity : From individualized Internet-delivered cognitive behavior therapy to affect-focused psychodynamic psychotherapy

Johansson

2013

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Robert JohanssonTreating depression and its comorbidity From individualized Internet-delivered cognitive behavior therapy to aect-focused psychodynamic psychotherapy AbstractDepression is a major health problem which lowers the quality of life for the individual and generates huge costs for society. Comorbidity between depression and anxiety disorders seems to be the rule rather than the exception. Evidence shows that comorbidity has consistently been associated with a poorer prognosis and greater demands for professional help. Prevalence studies show that many individuals with depression lack access to adequate treatment. Delivering psychological treatments through the Internet in the format of guided self-help is an innovative treatment strategy that has the potential to reach a large number of people. A majority of these treatments have been Internetdelivered cognitive behavior therapy (ICBT). The treatments contain structured material and interventions in the form of self-help text and are accompanied with online support from a therapist. The overarching goal of this thesis has been to enhance Internet-delivered psychological treatments for depression and its comorbidity. To this end, three randomized controlled trials (Study II, III and IV) with a total of 313 participants were conducted. A prevalence study (Study I) was also conducted to provide an up-to-date estimate of the prevalence of depression, anxiety disorders, and their comorbidity in the Swedish general population.In Study II, the efficacy of an individualized ICBT intervention that directly targeted depression and comorbid symptoms was tested. The treatment was compared to a standardized ICBT protocol and an active control group in the form of an online discussion group.Recent meta-analyses support the efficacy of psychodynamic psychotherapy in the treatment of depression. An Internet-based treatment protocol for depression, which was based on psychodynamic psychotherapy rather than CBT, was developed. In Study III, the efficacy of that protocol was evaluated in the treatment of depression.Preliminary evidence indicates that a focus on affect experience and expression may enhance psychodynamic therapies. In Study IV, a new Internet-based psychodynamic protocol was developed that had a strong focus on affect. It targeted both depression and anxiety disorders. The efficacy of that treatment was evaluated in a sample with mixed depression and anxiety.Study I showed that more than every sixth individual in Sweden suffers from symptoms of depression and/or anxiety. Comorbidity between depression and anxiety was substantial and associated with higher symptom burden and lower health-related quality of life. Study II showed that the tailored ICBT protocol was effective in reducing symptoms of depression when compared to the control group. Among individuals with more severe depression and comorbidities, the tailored ICBT treatment worked better than standardized ICBT. Study III showed that the psychodynamic Internet-based psychotherapy was highly effect...

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The Effect of Sertraline Add-On to Brief Dynamic Psychotherapy for the Treatment of Postpartum Depression

Abstract: clinicaltrials.gov Identifier: NCT01028482.

Cited by 60 publications

References 36 publications

Management of Peripartum Depression: Better, Prevent Than Treat!.

Management of Peripartum Depression: Better, Prevent Than Treat!.

Treatment of Depression During Pregnancy and the Postpartum Period

Treating depression and its comorbidity : From individualized Internet-delivered cognitive behavior therapy to affect-focused psychodynamic psychotherapy

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