The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum

Pommer, Stefan; Akamine, Yumiko; Schiffmann, Serge N.; d’Exaerde, Alban de Kerchove; Wickens, Jeffery R.

doi:10.1523/jneurosci.1037-20.2021

Cited by 6 publications

(5 citation statements)

References 79 publications

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“…Similar to D2Rs, 5-HT1BRs are GPCRs that couple to Gi/o proteins and are expressed on presynaptic terminals, where they mediate heterosynaptic depression of neurotransmitter release ( Tiger et al, 2018 ). We found that the 5-HT1B/1D agonist sumatriptan depressed D2-MSN→D1-MSN synapses as well as D1-MSN→D1-MSN synapses ( Figures 6E and S7A ), consistent with recent work ( Pommer et al, 2021 ). In addition, in the striatum, 5-HT1BRs are expressed on glutamate inputs and cholinergic interneurons, where they can depress glutamate and acetylcholine release ( Dölen et al, 2013 ; Mathur et al, 2011 ; Matsui and Alvarez, 2018 ; Virk et al, 2016 ).…”

Section: Discussionsupporting

confidence: 92%

Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens

Burke

Alvarez

2022

Cell Reports

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Section: Discussionsupporting

confidence: 92%

Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens

Burke

Alvarez

2022

Cell Reports

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“…This could be achieved by reversing the effect of paroxysmal migraine on the strength of the functional connection between the striatum and the occipital lobe; therefore, increasing the impulsivity of behavior. This finding is consistent with previous research showing that drug use may increase the impulsive behavior in patients (Pommer et al., 2021 ). This provides additional behavioral evidence for the choice of medication in the acute phase of migraine; therefore, the effects of medicine use in the acute phase on the incidence of chronic headache and drug abuse should be further explored.…”

Section: Discussionsupporting

confidence: 94%

“…The increased delayed discounting rate in patients with migraines may be caused by dysfunction of the 5‐hydroxytryptamine (5‐HT) system. Fibers of 5‐HT‐ergic neurons are distributed in the hypothalamus and limbic system of the central and play an important role in impulsive decision/delay discounting (Bacque‐Cazenave et al., 2020 ; Pommer et al., 2021 ; Salvan et al., 2023 ). Previous studies on decision‐making indicate that the activation of the 5‐HT system can increase the expectation of future benefits and make more patient choices (Desrochers et al., 2021 ; Miyazaki et al., 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Patients with episodic migraine without aura have an increased rate of delayed discounting

Wang,

Dai,

Gao

et al. 2024

Brain and Behavior

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ObjectiveThis study aimed to explore decision‐making impulsivity and its neural mechanisms in patients with episodic migraine without aura (EMoA).BackgroundPrevious evidence indicates increased impulsivity and altered reward processing in patients with chronic migraine and medication overuse; however, whether the same holds true for those with EMoA is unclear.MethodsPatients newly diagnosed with EMoA (n = 51) and healthy controls (HC, n = 45) were recruited. All participants completed delay discounting task, cognitive assessments, a questionnaire for headache profile, and resting‐state function magnetic resonance imaging scans. Resting‐state functional connectivity (RSFC) between the regions of interest and the entire brain was explored.ResultsPatients with EMoA showed a steeper subjective discount rate than HCs (F = 4.74, p = .032), which was positively related to a history of migraines (r = .742, p < .001). RSFC among the ventral striatum (vSTR), ventromedial prefrontal cortex, and occipital cortex was lower in patients with EMoA than in control groups, which was correlated with history (r′ = .294, p = .036) and subjective discount rate (r′ = .380, p = .006). Additionally, discounting rates and RSFC between the vSTR and occipital regions were significantly abnormal in the triptan group than the non‐triptan group. Mediating effect analysis indicated a significant mediating effect in the change in RSFC between the vSTR and occipital status, history of triptan use, and subjective discount rate.ConclusionThis study further elucidated that an increase in delayed discounting rate exists in patients with EMoA and is related to the abnormality of the value processing network.

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“…Serotonin and dopamine can have opposing effects on reward behavior, with serotonin generally having inhibitory effects on reward-seeking behavior while dopamine promotes it (Cools et al, 2011 ). 5-HT1 B Rs signal through Gi/o proteins to inhibit adenylyl cyclase, decrease cAMP production, and reduce neurotransmitter release in the dorsal striatum (Zhang et al, 2008 ; Pommer et al, 2021 ). Additionally, 5-HT2 C Rs inhibit dopamine release in the dorsal striatum (De Deurwaerdere et al, 2004 ).…”

Section: Interplay Of Dopamine and Serotonin Signaling For Emotional ...mentioning

confidence: 99%

Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling

Tsuboi,

Nagai,

Yoshimoto

et al. 2024

Front. Mol. Neurosci.

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The unraveling of the regulatory mechanisms that govern neuronal excitability is a major challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining the balance between excitatory and inhibitory activity in the brain. The balance controls cognitive functions and emotional responses. Glutamate and γ-aminobutyric acid (GABA) are the primary excitatory and inhibitory neurotransmitters of the brain, respectively. Disruptions in the balance between excitatory and inhibitory transmission are implicated in several psychiatric disorders, including anxiety disorders, depression, and schizophrenia. Neuromodulators such as dopamine and acetylcholine control cognition and emotion by regulating the excitatory/inhibitory balance initiated by glutamate and GABA. Dopamine is closely associated with reward-related behaviors, while acetylcholine plays a role in aversive and attentional behaviors. Although the physiological roles of neuromodulators have been extensively studied neuroanatomically and electrophysiologically, few researchers have explored the interplay between neuronal excitability and cell signaling and the resulting impact on emotion regulation. This review provides an in-depth understanding of “cell signaling crosstalk” in the context of neuronal excitability and emotion regulation. It also anticipates that the next generation of neurochemical analyses, facilitated by integrated phosphorylation studies, will shed more light on this topic.

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The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum

Abstract: The effect of serotonin receptor 5-HT1B on lateral inhibition between spiny projection neurons in the mouse striatum.

Cited by 6 publications

References 79 publications

Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens

Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens

Patients with episodic migraine without aura have an increased rate of delayed discounting

Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling

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