The Effect of Sericin on Bone Regeneration in a Streptozotocin-Induced Type I Diabetes Animal Model

Abstract

There is an association between diabetes and impaired bone healing. The purpose of this study was to determine whether sericin had a positive effect on bone regeneration with streptozotocin-induced diabetes in a rat model. Sprague Dawley rats (n = 21) were assigned to one of three groups. A critical-sized bone defect was created on the calvaria. In the sericin group (S group, n = 7), the bone defect was filled with a sericin–gelatin combination, whereas in the gelatin group (G group, n = 7), only gelatin sponge was used. The control group (N group, n = 7) did not receive any graft. New bone formation was evaluated by micro-computerized tomogram and histological analysis. The regenerated bone volume in group S was the highest among the three groups (3.87 ± 2.51 mm3), followed by group N (1.71 ± 1.65 mm3) and group G (1.24 ± 1.05 mm3). The application of sericin in combination with a gelatin sponge enhanced the process of bone regeneration in streptozotocin-induced type I diabetes animal model.

Multiple ways for the same destination: bone regeneration

“…Sericin can increase the expression level of BMP-2 in the macrophage [ 48 ]. The gelatin sponge incorporated with sericin can increase new bone formation compared to the gelatin sponge only graft [ 48 , 49 ].…”

“…Medication-related jaw bone necrosis is a drug complication induced by impaired angiogenesis [ 50 ]. Diabetic bony lesion has also shown poor vascularity [ 49 ]. PDGF is rich in platelets.…”

Special Issue on Immunomodulation and Smart Materials for the Application of Maxillofacial Surgery

“…Kim et al [4] reported that 4HR acts as a novel class I histone deacetylase (HDAC) inhibitor, effectively reducing its expression and activity. Hong et al [5] reported that the application of sericin combined with a gelatin sponge significantly enhanced bone regeneration in a diabetic animal model, as evidenced by increased regenerated bone volume compared to control groups. Jang et al [6] reported that 4HR administration reduced root resorption during orthodontic tooth movement in rats, while increasing the expression levels of bone regeneration associated markers, suggesting its potential protective effect against root resorption.…”