The Effect of Selenium Therapy on Semen Parameters, Antioxidant Capacity, and Sperm DNA Fragmentation in Men with Idiopathic Oligoasthenoteratospermia

Alahmar, Ahmed T

doi:10.1007/s12011-023-03638-8

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…Moreover, in another study, an increase in progressive and total sperm motility in men with idiopathic OAT was observed after treatment with coenzyme Q10 (200 mg/day) for 3 months [25]. Furthermore, sperm concentration, progressive motility, and total motility increased significantly in men with infertility and OAT when compared to fertile controls, following the administration of selenium (200 µg/day) daily for 6 months [26]. Dadgar et al [27] demonstrated the beneficial effects of co-administering pentoxifylline and zinc in men with idiopathic infertility, including significant improvements in normal morphology, DNA integrity, and reproductive hormones.…”

Section: Discussionmentioning

confidence: 88%

Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia

Rochdi,

Ouadrhiri,

Allai

et al. 2024

Clin Exp Reprod Med

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Objective: Recently, oral antioxidants in combined forms have been used to treat men with idiopathic infertility. This study aimed to evaluate the effects of treatment with vitamin C, vitamin E, selenium, zinc, arginine, L-carnitine, and coenzyme Q10 on sperm quality parameters, DNA integrity, reproductive hormones, and pregnancy rates in men with infertility and idiopathic oligoasthenoteratozoospermia (OAT).Methods: A prospective study was conducted on 420 men with infertility and idiopathic OAT who took an oral supplement of antioxidant SP-Power tablets twice daily for 6 months. Semen quality, reproductive hormones, and the DNA fragmentation index (DFI) were evaluated at baseline and at 3 and 6 months after supplementation, using the World Health Organization 2021 guidelines. Results: No significant difference was observed in volume or the percentage of typical morphology during treatment. A significant improvement in sperm concentration was observed after supplementation (8.67±1.41, 12.17±1.91, and 19.01±0.86 at baseline, 3, and 6 months respectively, p<0.01). The total motility, progressive motility, and total motile sperm count also increased significantly (p<0.01), whereas the DFI decreased after 6 months. There was an increase in normal FSH levels and testosterone levels after 6 months of supplementation of antioxidant SP-Power but these differences were not statistically significant (p=not significant and p=0.06, respectively).Conclusion: Supplementation with SP-Power tablets improved sperm quality parameters, sperm DFI, some reproductive hormones, and pregnancy rates in men with infertility and idiopathic OAT, which could be attributed to the supplement’s synergistic antioxidant action. Further studies are needed to determine the effects of supplementation on oxidative stress markers.

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Section: Discussionmentioning

confidence: 88%

Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia

Rochdi,

Ouadrhiri,

Allai

et al. 2024

Clin Exp Reprod Med

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“…This underscores the importance of maintaining Se intake within safe limits to avoid detrimental health consequences. Also, the diminished Se levels in the body are implicated in compromised fetal development, male infertility, and heightened susceptibility to asthma [ 130 , 161 , 162 ]. These effects stem from the attenuation of antioxidant defenses and the reduction in activity of glutathione peroxidase [ 126 ].…”

Section: The Influence Of Selenium In the Environment And Selenium-en...mentioning

confidence: 99%

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Leszto,

Biskup,

Korona

et al. 2024

Antioxidants

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Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehending the underlying mechanisms and developing strategies for prevention and treatment. Selenium, a crucial participant in redox reactions, emerges as a notable factor in maintaining myocardial cell homeostasis and influencing the progression of cardiovascular disorders. Some disorders, such as Keshan disease, are directly linked with its environmental deficiency. Nevertheless, the precise extent of its impact on the cardiovascular system remains unclear, marked by contradictory findings in the existing literature. High selenium levels have been associated with an increased risk of developing hypertension, while lower concentrations have been linked to heart failure and atrial fibrillation. Although some trials have shown its potential effectiveness in specific groups of patients, large cohort supplementation attempts have generally yielded unsatisfactory outcomes. Consequently, there persists a significant need for further research aimed at delineating specific patient cohorts and groups of diseases that would benefit from selenium supplementation.

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“…Alahmar et al did a study where they used CoQ10 200 milligrams or selenium 200 micrograms/day in 70 patients with idiopathic OAT for 3 months and found a boost in antioxidant status, motility, and sperm concentration while when they gave selenium 200 micrograms/day in 65 patients with idiopathic OAT, it lowers sperm DNA fragmentation (SDF) and raises the concentration of sperm, seminal antioxidant capacity and motility [ 32 , 33 ].…”

Section: Reviewmentioning

confidence: 99%

Role of Dietary Antioxidant Supplements in Male Infertility: A Review

Ghewade,

Vagha,

Ghewade

et al. 2024

Cureus

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Infertility, which affects around 70 million couples globally, is the inability to conceive after at least a year of continuous, unprotected sexual activity. Male-related elements are involving half of all infertility cases globally. Male infertility has various characteristics, including oligospermia, asthenozoospermia, and teratozoospermia. The purpose of this study was to assess the impact of antioxidant-rich food supplements on the properties of semen, like concentration of sperm, morphology, motility, fertility rate, and damage of DNA. Terms such as coenzyme Q10, antioxidants, folic acid, vitamin C, vitamin E, male infertility, selenium and others, were used to search for relevant research papers in the PubMed database. The findings of this study demonstrated beneficial improvements in semen parameters among infertile men who consumed dietary supplements, particularly combining antioxidants like coenzyme Q10, vitamin C, and vitamin E.

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The Effect of Selenium Therapy on Semen Parameters, Antioxidant Capacity, and Sperm DNA Fragmentation in Men with Idiopathic Oligoasthenoteratospermia

Cited by 5 publications

References 46 publications

Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia

Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Role of Dietary Antioxidant Supplements in Male Infertility: A Review

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