The Effect of Selenium Modified Carbon Dioxide Mineral Waters of Pyatigorsk Field on Some Selenium Depended Systems

Abstract

The influence of course intake of the natural mineral water of the Pyatigorsk source, modified by selenium nanoparticles at a dosage of 40 μg/kg, on the level of thyroid hormones, insulin, cortisol and dehydroepiandrosterone, including depending on the method of drinking animals (free drinking and intragastric) was studied in rats. The histological structure of the thyroid gland during drinking with mineral water corresponded to that of healthy control animals, but in the group that received water intragastrically through the probe, the function of thyrocytes and levels of triiodothyronine and dehydroepiandrosterone in the blood were reduced. The courses of the mineral water modified by selenium nanoparticles, according to the data of multiple linear regression, contributed to the activation of the thyroid system.