The Effect of Secretin and Cholecystokinin‐pancreozymin on the Secretion of Bile in the Anaesthetized Rabbit

Esteller, A; López, María Rodríguez; Murillo, A

doi:10.1113/expphysiol.1977.sp002407

Cited by 11 publications

(7 citation statements)

References 7 publications

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“…In rabbits with the gall bladder intact, the bile flow was lower in these experiments than had been found in conscious rabbits by Shaw & Heath (1974) and by Esteller, Lopez & Murillo (1977), Kirchmayer, Tarnawski, Drozdz & Cichecka (1972), Klaassen (1973) and Rutihauser & Stone (1975) in anaesthetized animals. The first day after surgery, the rate of flow lay between the value observed in anaesthetized animals and that found subsequently in the present work.…”

Section: Resting Secretionsupporting

confidence: 40%

Biliary Secretion in Conscious Rabbits: Role of the Enterohepatic Circulation of Bile Salts and of the Gall Bladder

1981

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SUMMARYThe role of enterohepatic circulation of bile salts in biliary secretion in conscious rabbits has been investigated before and after cholecystectomy. Bile flow was higher and bile salt concentration lower in cholecystectomized than in intact rabbits: this could have been caused by a negative feed-back effect on bile salt synthesis as the circulating bile salt pool increased. The effects of cholecystectomy on flow and bile salt concentration balanced each other. Bile flow and bile salt concentration declined after interruption of the enterohepatic circulation in both cholecystectomized and intact rabbits. Furthermore, the percentage of the flow of bile independent of bile salt secretion increased, while that independent of total analysed solutes decreased after the enterohepatic circulation was broken. These results confirm that the decrease in bile flow after interruption of the enterohepatic circulation is due to loss of bile salts and not of electrolytes.

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Section: Resting Secretionsupporting

confidence: 40%

Biliary Secretion in Conscious Rabbits: Role of the Enterohepatic Circulation of Bile Salts and of the Gall Bladder

1981

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“…The values obtained were similar to those previously reported by Klaassen (1974) and Esteller, Lopez and Murillo (1977) for urethane-anaesthetized animals and by Shaw and Heath (1974) and Esteller, Jimenez and Lopez (1981) for un anaesthetized animals, although they were lower than those reported by other workers for rabbits anaesthetized with pentobarbital (Erlinger et al, 1970) or for unanaesthetized animals (DiPadova et al, 1981). The data for bile acid output did not explain the differences in bile flow under the anaesthetics and point to the notion that such differences would not be related to bile-acidCollado, Pow-Andrada, Gonzalez, Jimenez & Esteller dependent secretion.…”

Section: Discussionsupporting

confidence: 82%

“…The potassium plasma concentration was lower for both agents than has been reported pentobarbital (Klaassen, 1974;Rutishauser & Stone, 1975;Esteller, Lopez & Murillo, 1977). The bile-to-plasma [14C]erythritol ratios were similar to those reported by Klaassen (1974) with urethane and by Erlinger et al (1970) with pentobarbital and point to a slight ductular reabsorption.…”

Section: Discussionsupporting

confidence: 47%

Effect of pentobarbital or urethane on bile secretion and chemical composition of blood in the rabbit

et al. 1987

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SummaryA study was made of the effects of anaesthesia with pentobarbital and urethane on the bile secretion and the chemical composition of the blood of New Zealand rabbits. Neither of the agents was observed to affect arterial pH or p02' but with urethane pC02 values decreased significantly. This was assoeiated with a pronounced hyperglycaemia. Bile flow was significantly higher in pentobarbital-anaesthetized animals than in urethane-anaesthetized animals, a phenomenon that can be attributed to a different canalicular flow and that will not be related to differences in the bile-aeid-dependent fraction of secretioQ. Under both anaesthetics, bile sodium concentrations were greater than those found in plasma, which can be explained by the formation of micelles with low osmotic activity. Bile bicarbonate concentrations proved to be greater than those observed in plasma. Plasma caleium concentrations were significantly lower with urethane than with pentobarbital, whereas in bile the situation was reversed; both these aspects are discussed.Keywords: Anaesthesia, general; Pentobarbital; Urethane; Bile; Blood; Rabbits Anaesthetics have several effects on the structure and functioning of numerous organs and biological systems and such effects have been the subject of diverse research work; the possible modifications that these compounds may induce in biliary secretion have received little attention, however. This is rather paradoxical in view of the fact that numerous experiments in hepatic physiology and

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“…Firstly, direct nervous influences, although the observations of Esteller, Lopez & Murillo (1977a) on anaesthetized rabbits would appear to discount these. Secondly, the liberation of cholecystokinin, which could act on the gall bladder in the same way as in anaesthetized rabbits (Esteller, Lopez & Murillo, 1977b;Kirchmayer, Tarnawski, Drozdz & Cichecka, 1972) and which could thus partially explain the shorter biliary response seen in the cholecystectomized animals (Fig. 1).…”

Section: Discussionmentioning

confidence: 96%

Biliary Response to Food in Rabbits: Role of the Gall Bladder and the Enterohepatic Circulation of Bile Salts

1981

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The biliary response to feeding has been investigated in intact and cholecystectomized rabbits, with and without interruption of the enterohepatic circulation of bile salts. The relative contribution of the different secretory mechanisms involved in this process has been examined. Feeding induced an increase in the flow and bicarbonate concentration of the bile and a slight decrease in the bile salt content in rabbits with gall bladders and the enterohepatic circulation intact. Feeding with the enterohepatic circulation interrupted elicited a drop in bile flow and the bile salt concentration, but an increase in bicarbonate concentration. Interruption of the enterohepatic circulation thus dramatically modifies the feeding response: a response to food is still detectable after interruption, but is masked by the negative effects of drainage of the bile away from the duodenum.

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The Effect of Secretin and Cholecystokinin‐pancreozymin on the Secretion of Bile in the Anaesthetized Rabbit

Cited by 11 publications

References 7 publications

Biliary Secretion in Conscious Rabbits: Role of the Enterohepatic Circulation of Bile Salts and of the Gall Bladder

Biliary Secretion in Conscious Rabbits: Role of the Enterohepatic Circulation of Bile Salts and of the Gall Bladder

Effect of pentobarbital or urethane on bile secretion and chemical composition of blood in the rabbit

Biliary Response to Food in Rabbits: Role of the Gall Bladder and the Enterohepatic Circulation of Bile Salts

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