Objective: The purpose of this study was to evaluate the effectiveness of posterior mono axial pedicle screws fixation in the treatment of thoracolumbar burst fractures.Methods: In the present study we analyzed 50 patients retrospectively who had thoracolumbar burst fractures without a neurological deficit. Patients were divided into 2 groups: mono axial pedicle Screw fixation group (n = 25) and poly axial pedicle Screw fixation group (n = 25). We collected clinical data (visual analog scale score for back pain) and included radiographic measurements. The latter were used to calculate the sagittal plane kyphosis.Results: For the mono group, the preoperative mean sagittal index (SI) was O.59 ± 0.12 (range, 0.37–0.77), and the last follow up sagittal index (SI)was O.76 ± 0.09 (range, 0.56–0.89). For the poly group, the preoperative sagittal index (SI) was O.57 ± 0.11 (range, 0.34–0.82),and the last follow up sagittal index (SI) was O.65 ± 0.11 (range, 0.36–0.87). For the mono group, the mean postoperative regional kyphosis correction rate was 62.31%, and correction loss was 14.18% in late follow-up. For the poly group, the mean postoperative regional kyphosis correction rate was 52.17%, and correction loss was 33.42% in late follow-up. The mono axial pedicle screw group had good correction rate, and reduce the risks of correction loss. The mean visual analog scale (VAS) scores for back pain improved by 2.4/2.5 and 3.8/4.2 for the mono and poly groups. There was no significant difference between groups.Conclusions: The mono axial pedicle screw fixation was better for reducing and maintaining anterior vertebral height and regional kyphosis. Therefore, the mono axial pedicle screw is a better optional instrumentation to treat thoracolumbar vertebral fractures.