The effect of <scp>NB</scp>‐<scp>UVB</scp> on noncultured melanocyte and keratinocyte transplantation in treatment of generalized vitiligo using two different donor‐to‐recipient ratios

Tawfik, Yasmin M; Elazim, Nagwa Essa Abd; Abdel-Motaleb, Amira A.; Mohammed, Rabab Ahmed Ahmed; Tohamy, Ahmed Mohamed Ali

doi:10.1111/jocd.12759

Cited by 18 publications

(27 citation statements)

References 30 publications

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“…Two studies directly compared different expansion ratios and their repigmentation after NCST. 16,17 In the study of Tegta et al, 16 repigmentation after NCST was compared between a 1:3 expansion ratio group (n = 10 patients) and a 1:5 expansion ratio group (n = 10 patients). Three months after transplantation, 5 patients in the 1:3 group had a >75% repigmentation response; whereas, no patients in the 1:5 group reached this response (P < 0.05).…”

Section: Studies Comparing Dr Expansion Ratios In Ncstmentioning

confidence: 99%

Donor to recipient ratios in the surgical treatment of vitiligo and piebaldism: a systematic review

Narayan¹,

Bol²,

Geel

et al. 2021

Acad Dermatol Venereol

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Stabilized vitiligo resistant to conventional therapy (e.g. segmental vitiligo) and piebaldism lesions can be treated with autologous cellular grafting techniques, such as non-cultured cell suspension transplantation (NCST) and cultured melanocyte transplantation (CMT). These methods are preferred when treating larger surface areas due to the small amount of donor skin needed. However, the donor to recipient expansion ratios and outcomes reported in studies with cellular grafting vary widely, and to date, no overview or guideline exists on the optimal ratio. The aim of our study was to obtain an overview of the various expansion ratios used in cellular grafting and to identify whether expansion ratios affect repigmentation and colour match. We performed a systematic literature search in MEDLINE and EMBASE to review clinical studies that reported the expansion ratio and repigmentation after cellular grafting. We included 31 eligible clinical studies with 1591 patients in total. Our study provides an overview of various expansion ratios used in cellular grafting for vitiligo and piebaldism, which varied from 1:1 up to 1:100. We found expansion ratios between 1:1 and 1:10 for studies investigating NCST and from 1:20 to 1:100 in studies evaluating CMT. Pooled analyses of studies with the same expansion ratio and repigmentation thresholds showed that when using the lowest (1:3) expansion ratio, the proportion of lesions achieving >50% or >75% repigmentation after NCST was significantly better than when using the highest (1:10) expansion ratio (v 2 P = 0.000 and v 2 P = 0.006, respectively). Less than half of our included studies stated the colour match between different expansion ratios, and results were variable. In conclusion, the results of our study indicate that higher expansion ratios lead to lower repigmentation percentages after NCST treatment. This should be taken into consideration while determining which expansion ratio to use for treating a patient.

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Section: Studies Comparing Dr Expansion Ratios In Ncstmentioning

confidence: 99%

Donor to recipient ratios in the surgical treatment of vitiligo and piebaldism: a systematic review

Narayan¹,

Bol²,

Geel

et al. 2021

Acad Dermatol Venereol

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“…Moreover, in two cases, although the donor-to-recipient ratio acquired for the NCES exceeded 1 : 10, they still had very good repigmentation. We emphasize that with careful patient selection and good control of the aforementioned factors, high success rates of NCES can be achieved regardless of the recipient vitiliginous size [10]. Although the incidence of adverse reactions on both the donor and recipient sites of the first and second NCESs did not differ, 1 patient from the second NCES group experienced hypertrophic scar on the donor site.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Repeated Use of Donor Site for Noncultured Epidermal Cellular Grafting in Stable Vitiligo: A Retrospective Study

Vachiramon

Triyangkulsri

Saengwimol

et al. 2019

BioMed Research International

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Background Noncultured epidermal suspension (NCES) is a surgical technique which employs cellular grafting onto depigmented lesions. However, scarring and dyschromia at the donor site often occurs. Objective To assess the outcome of reusing the same donor site in subsequent sessions of NCES procedures. Methods Electronic records of vitiligo patients who had undergone two sessions of NCES procedures were retrospectively reviewed. Information on the first and second NCES was retrieved for analyses. Results A total of 30 patients (female 19 and male 11) were included. The majority of patients had nonsegmental vitiligo (66.7%). The median donor-to-recipient ratios were 1 : 3 (1 : 1–1 : 20) for the first session and 1 : 3 (1 : 1–1 : 13.5) for the second session (p=0.661). The mean melanocyte count was 220.7 ± 65.5 cells/mm2 vs. 242.4 ± 55.3 cells/mm2 on the first and second sessions, respectively (p=0.440). The mean repigmentation rate was 84.2% (±21.1%) and 82.3 (±22.1%) for the first and second NCESs, respectively (p=0.645). The frequency of color mismatch and pigment loss were similar between both sessions (p=0.706 and p=1.000). Conclusions Repeated use of donor sites in subsequent NCES sessions gave comparable repigmentation.

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“…Since the pathogenesis of vitiligo is not fully understood, a variety of modalities have been attempted to stabilize progression and stimulate repigmentation 9–13. These include topical therapies9 (eg, topical corticosteroids,9,12,14,15 calcineurin inhibitors,9,16,17 vitamin D analogues9,12,18), systemic therapies19 (eg, corticosteroids,9,12 methotrexate9), surgical therapies20 (eg, melanocyte-keratinocyte transplantation,21–25 hair follicle transplant,26,27 punch, blister, split thickness grafting26–28), complementary and alternative therapies29 (eg, L-phenylalanine, khellin, biloba, folic acid, zinc, copper, vitamins B12, C, D, and E), and a variety of experimental therapies (eg, afamelanotide,19,30 topical prostaglandin E2,19,31 systemic and topical Janus kinase inhibitors,19,32–34 apremilast,19 topical Wnt agonists19).…”

Section: Diagnosis and Management Of Vitiligomentioning

confidence: 99%

<p>Home phototherapy for patients with vitiligo: challenges and solutions</p>

Smith¹,

Ly²,

Thibodeaux³

et al. 2019

CCID

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Vitiligo is a chronic autoimmune condition involving selective dysfunction and destruction of melanocytes in the skin, hair, or both. The typical presentation is well-demarcated depigmented skin patches. Given vitiligo is the most common cause of depigmentation worldwide and early disease responds best to treatment, prompt diagnosis and proactive management of vitiligo are critical. While a wide variety of treatments has demonstrated variable effectiveness in treating vitiligo, phototherapy remains standard of care because of its proven efficacy and favorable side effect profile. However, many patients with vitiligo are unable to access affordable, consistent, or convenient phototherapy. To address these issues, home-based phototherapy has emerged as a patient-centered alternative. The purpose of this review is to discuss management of vitiligo with a specific focus on access to home-based phototherapy (HBPT) for patients with this condition. Key challenges to HBPT include misperceptions around safety and efficacy, inadequate physician education and training, insurance and financial barriers, and appropriate patient selection. Solutions to these challenges are presented, such as approaches to improve physician education and increasing the evidence surrounding the effectiveness and safety of this treatment for vitiligo. In addition, various practical considerations are discussed to guide dermatologists on how to approach HBPT as a treatment option for patients with vitiligo.

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The effect of NB‐UVB on noncultured melanocyte and keratinocyte transplantation in treatment of generalized vitiligo using two different donor‐to‐recipient ratios

Cited by 18 publications

References 30 publications

Donor to recipient ratios in the surgical treatment of vitiligo and piebaldism: a systematic review

Donor to recipient ratios in the surgical treatment of vitiligo and piebaldism: a systematic review

Outcome of Repeated Use of Donor Site for Noncultured Epidermal Cellular Grafting in Stable Vitiligo: A Retrospective Study

<p>Home phototherapy for patients with vitiligo: challenges and solutions</p>

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