The effect of school dental care on caries, oral hygiene, gingivitis, and calculus in Western Australian children

Medcalf, G. W.

doi:10.1111/j.1834-7819.1983.tb02958.x

Cited by 4 publications

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“…It has been demonstrated that PERK activity can induce cellular inhibitor of apoptosis (cIAP1 and cIAP2) proteins, leading to the inhibition of ER stress-induced apoptotic program [140]. The ER stress inducing agents can activate the phosphatidylinositol 3-kinase (PI3K)–Akt signaling pathway, which is involved in the transcriptional induction of IAPs [141,142,143,144].…”

Section: Chemotherapy Resistance: Role Of Endoplasmic Reticulum Stmentioning

confidence: 99%

Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling

Bahar

Kim

Yoon

2019

Cancers

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Cancers cells have the ability to develop chemotherapy resistance, which is a persistent problem during cancer treatment. Chemotherapy resistance develops through different molecular mechanisms, which lead to modification of the cancer cells signals needed for cellular proliferation or for stimulating an immune response. The endoplasmic reticulum (ER) is an important organelle involved in protein quality control, by promoting the correct folding of protein and ER-mediated degradation of unfolded or misfolded protein, namely, ER-associated degradation. Disturbances of the normal ER functions causes an accumulation of unfolded or misfolded proteins in the ER lumen, resulting in a condition called “ER stress (ERS).” ERS triggers the unfolded protein response (UPR)—also called the ERS response (ERSR)—to restore homeostasis or activate cell death. Although the ERSR is one emerging potential target for chemotherapeutics to treat cancer, it is also critical for chemotherapeutics resistance, as well. However, the detailed molecular mechanism of the relationship between the ERSR and tumor survival or drug resistance remains to be fully understood. In this review, we aim to describe the most vital molecular mechanism of the relationship between the ERSR and chemotherapy resistance. Moreover, the review also discusses the molecular mechanism of ER stress-mediated apoptosis on cancer treatments.

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Section: Chemotherapy Resistance: Role Of Endoplasmic Reticulum Stmentioning

confidence: 99%

Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling

Bahar

Kim

Yoon

2019

Cancers

View full text Add to dashboard Cite

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Trends in dental caries: Australian adolescents

Spencer

1986

Australian Dental Journal

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An investigation of trends in dental caries in the Australian adolescent population was possible through the development of a predictive model for caries severity. Past associations of predictor variables with caries severity were separated out from a wide range of ad hoc surveys, clinical trials, and analyses of service records. National trends in the identified predictor variables were then used to predict past and future caries severity for the Australian adolescent population. Caries severity marginally decreased between 1965 to 1970. Over the period 1970 to 1980 caries severity markedly decreased. Caries severity was predicted to continue to decrease over the period 1980 to 1990, but with evidence of a plateauing for younger adolescents by 1990. Marked increases in percentages of younger adolescents caries-free between 1975 and 1990 were also predicted. The predictions appeared to be tracking adequately with subsequently available data.

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The dental status of 15‐year‐old South Australian students

Srikandi

1987

Australian Dental Journal

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An exploratory study of the dental health and habits of 15‐year‐old students from different socioeconomic levels revealed a generally low prevalence of caries experience (DMFT 3.3). Shallow periodontal pockets were found in an average of 0.4 sextants among 19.5 per cent of students, but gingivitis, calculus and overhanging margins of restorations were very common. The highest treatment needs were for oral health education (97.6 per cent) and scaling (69.6 per cent). Socioeconomic level was associated with the dental visit pattern and dental status; this confirmed other studies that found that the lower socio‐economic groups were at a disadvantage. There were indications that some minority ethnic groups had higher caries experiences and lower dental service utilization.

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The effect of school dental care on caries, oral hygiene, gingivitis, and calculus in Western Australian children

Cited by 4 publications

References 0 publications

Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling

Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling

Trends in dental caries: Australian adolescents

The dental status of 15‐year‐old South Australian students

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