The effect of scatter correction and radius of rotation on semiquantitative measurements in SPECT 123I-FP-CIT imaging. A phantom study

Papanastasiou, Emmanouil; Katsiva, Christina; Doumas, Argyrios; Gerasimou, Georgios; Σιούντας, Αναστάσιος

doi:10.1016/j.ejmp.2019.12.009

Cited by 2 publications

(8 citation statements)

References 13 publications

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“…As 123 I decays to Tellurium-123 ( 123 Te) -1 -by electron capture, it emits a gamma photon with an energy of 159 keV (83%), which is used basically in 123 I imaging. Otherwise, this isotope also emits another photon with an energy of 529 keV (1.39%) [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…As for 123 I imaging, except for 159 keV gamma rays, other gamma rays are not used in nuclear medicine imaging due to their low abundance of decay. However, these high-energy gamma rays are the main source of penetration and scattering [3,[11][12][13][14]. Namely, high energy photons penetrate through the collimator, these penetrated high-energy photons cross the crystal and Compton-scattered in the electronic elements behind the crystal.…”

Section: Introductionmentioning

confidence: 99%

“…It is mentioned that the total amount of the penetrated high-energy photons in the photopeak window could be 49%-60% of the detected photons [15]. Different publications have emphasized that these penetration and scatter events degrade image quality [2,3,10,11,16].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, various scatter correction methods are suggested by several investigators to decrease the contribution of Compton-scattered photons affecting the quantitative and qualitative accuracy of the images [3,7,8,13,[17][18][19][20][21]. Commonly used scatter correction methods in nuclear medicine imaging systems are dual-energy window (DEW), triple-energy window (TEW, trapezoidal and triangular approximation), dual-photopeak window (DPW), photopeak energy distribution analysis (PEDA), channel ratio (CRM), and downscatter correction.…”

Section: Introductionmentioning

confidence: 99%

“…These long-used methods in gamma spectroscopic measurements are a spectral analysis approaches based on subtracting the scatter energy windows, set on the Compton region of the spectrum, from the net peak area [18,20,21]. Many phantom and simulation studies on the DEW/TEW scatter correction methods in 99m Tc/ 123 I imaging have been conducted and concluded that the scatter correction methods enhance image quality in both planar and SPECT images [2,3,7,9,13,17,19,[22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A study on energy window-based scatter correction methods in ^99mTc and ¹²³I imaging

Can,

Karadeniz,

Çapa Kaya

et al. 2023

J. Inst.

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Tc-99m and I-123 are radionuclides commonly used for diagnostic examination in nuclear medicine. Detection of the scattered photons by the Compton interactions in the photopeak energy window is a factor affecting the image quality. DEW and TEW scatter correction methods are used to improve the image quality degrade by Compton scattered photons. In the study, planar and SPECT images of sphere, rod and cardiac phantom containing different activities were acquired with a gamma camera system. DEW/TEW corrected and uncorrected images for Tc-99m/I-123 were evaluated qualitatively and quantitatively. Both for planar and SPECT images, the DEW and TEW scatter correction methods were found to improve the image quality at varying rates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A study on energy window-based scatter correction methods in ^99mTc and ¹²³I imaging

Can,

Karadeniz,

Çapa Kaya

et al. 2023

J. Inst.

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Convolutional neural network based attenuation correction for ¹²³I-FP-CIT SPECT with focused striatum imaging

2021

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SPECT imaging with 123 I-FP-CIT is used for diagnosis of neurodegenerative disorders like Parkinson's disease. Attenuation correction (AC) can be useful for quantitative analysis of 123 I-FP-CIT SPECT. Ideally, AC would be performed based on attenuation maps (m-maps) derived from perfectly registered CT scans. Such m-maps, however, are most times not available and possible errors in image registration can induce quantitative inaccuracies in AC corrected SPECT images. Earlier, we showed that a convolutional neural network (CNN) based approach allows to estimate SPECT-aligned m-maps for full brain perfusion imaging using only emission data. Here we investigate the feasibility of similar CNN methods for axially focused 123 I-FP-CIT scans. We tested our approach on a highresolution multi-pinhole prototype clinical SPECT system in a Monte Carlo simulation study. Three CNNs that estimate m-maps in a voxel-wise, patch-wise and image-wise manner were investigated. As the added value of AC on clinical 123 I-FP-CIT scans is still debatable, the impact of AC was also reported to check in which cases CNN based AC could be beneficial. AC using the ground truth m-maps (GT-AC) and CNN estimated m-maps (CNN-AC) were compared with the case when no AC was done (No-AC). Results show that the effect of using GT-AC versus CNN-AC or No-AC on striatal shape and symmetry is minimal. Specific binding ratios (SBRs) from localized regions show a deviation from GT-AC  2.5% for all three CNN-ACs while No-AC systematically underestimates SBRs by 13.1%. A strong correlation (  r 0.99) was obtained between GT-AC based SBRs and SBRs from CNN-ACs and No-AC. Absolute quantification (in kBq ml −1 ) shows a deviation from GT-AC within 2.2% for all three CNN-ACs and of 71.7% for No-AC. To conclude, all three CNNs show comparable performance in accurate m-map estimation and 123 I-FP-CIT quantification. CNNestimated m-map can be a promising substitute for CT-based m-map.

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The effect of scatter correction and radius of rotation on semiquantitative measurements in SPECT 123I-FP-CIT imaging. A phantom study

Cited by 2 publications

References 13 publications

A study on energy window-based scatter correction methods in ^99mTc and ¹²³I imaging

A study on energy window-based scatter correction methods in ^99mTc and ¹²³I imaging

Convolutional neural network based attenuation correction for ¹²³I-FP-CIT SPECT with focused striatum imaging

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The effect of scatter correction and radius of rotation on semiquantitative measurements in SPECT 123I-FP-CIT imaging. A phantom study

Cited by 2 publications

References 13 publications

A study on energy window-based scatter correction methods in 99mTc and 123I imaging

A study on energy window-based scatter correction methods in 99mTc and 123I imaging

Convolutional neural network based attenuation correction for 123I-FP-CIT SPECT with focused striatum imaging

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A study on energy window-based scatter correction methods in ^99mTc and ¹²³I imaging

A study on energy window-based scatter correction methods in ^99mTc and ¹²³I imaging

Convolutional neural network based attenuation correction for ¹²³I-FP-CIT SPECT with focused striatum imaging