The Effect of Route of Inoculation on Protection by Killed Vaccines in Chickens

Nakamura, Toshihiro; Hoshi, Seiko; Nagasawa, Yoji; Ueda, Seinosuke

doi:10.2307/1591802

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…With respect to vaccine development, the route of immunization or site of administration may play a prominent role in shaping the type of immune response that develops. In support of this concept, a recent report has shown that the route of immunization influenced the ability of chickens to prevent lung infections following intratracheal challenge with Mycoplasma gallisepticum (24). Here, we report experiments examining the influence of the site of administration of the mouse pneumonitis biovar of C. trachomatis (MoPn) on the cytokine pattern (Th1 versus Th2) which develops in response to a vaginal challenge with MoPn and the ability of different routes to protect mice from developing a vaginal infection.…”

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confidence: 93%

Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection

1996

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A Th1-type response develops following vaginal infection with the mouse pneumonitis biovar of Chlamydia trachomatis (MoPn). Since the type of response, i.e., Th1 versus Th2, can be influenced by factors present during T-cell activation, we examined the effects of different routes of MoPn administration on the cytokine profile and resistance against infection following a MoPn vaginal challenge. A dominant Th1-type cytokine profile developed in mice given live MoPn via the intranasal, oral, and vaginal routes with ratios of gamma interferon-secreting cells to interleukin 4-secreting cells greater than 10. In contrast, mice injected subcutaneously produced a Th2-type profile with a gamma interferon/interleukin 4 ratio of only 0.7. These mice also had significantly higher anti-MoPn immunoglobulin G1 serum titers, confirming a Th2-type cytokine profile. Exposure of mice to live MoPn, by any route prior to vaginal challenge, resulted in a shortened course of infection. However, the subcutaneous group resolved the vaginal infection more slowly, with 60% (6 of 10 mice) of the mice still isolation positive 12 days after challenge compared with only 20% of mice given live MoPn by other routes. Administration of UV-inactivated MoPn did not provide protection against a vaginal challenge. The decreased ability to clear infection was not associated with a shift in the cytokine profile, since intranasal and oral administration of UV-inactivated MoPn resulted in a predominant Th1-type response. Taken together, these data indicate that the initial route of MoPn administration can direct the type of response produced after a local MoPn infection and thus influence the ability of the immune response to protect against subsequent infection.

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confidence: 93%

Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection

1996

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“…Interaction with maternal antibodies against this antigen is not possible, which ensures that no differences exist between broiler-and layer-type chickens concerning responses to TNP-KLH. Because the immunization route for non-replicating or dead antigens influences the humoral and cellular immune response significantly in chickens (Nakamura et al, 1995;van der Zijpp et al, 1986) and mice (Thatte et al, 1995), we first investigated which immunization route (intravenous, ocular, intramuscular or subcutaneous) resulted in the optimal antibody responses. Subsequently, we compared the humoral response to different concentrations of TNP-KLH (administered intravenously) in broiler-(Ross) and layer (White Leghorn)-type chickens.…”

Section: Introductionmentioning

confidence: 99%

Immunological differences between layer- and broiler-type chickens

Koenen

Boonstra-Blom

Jeurissen

2002

Veterinary Immunology and Immunopathology

121

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“…As expected, immunity does play a role in protection from mycoplasma diseases. Vaccination against mycoplasma disease is possible (33)(34)(35)(36)(37)(38)(39)(40)(41). Mucosal IgA responses are likely important in resistance to disease associated with mycoplasma infection of mucosal surfaces (42,43).…”

Section: The Complexity Of Immune Interactions With Mycoplasmamentioning

confidence: 99%

T lymphocyte responses are critical determinants in the pathogenesis and resistance to mycoplasma respiratory disease

Jones

Simecka

2003

Front Biosci

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Mycoplasmas are responsible for many human and animal respiratory diseases and have a tremendous economic and health impact worldwide. Currently, there is no vaccine against any animal or human mycoplasma species. Despite the vast amount of research, the mechanisms that control hosts' resistance and susceptibility to mycoplasma infection remains unclear. Immune responses, particularly T lymphocyte responses, are believed to be critical players in the pathogenesis of mycoplasma disease. In this review, we will highlight the potential roles of T lymphocytes as influential mediators in animal and human mycoplasma pathogenesis and resistance infection.

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The Effect of Route of Inoculation on Protection by Killed Vaccines in Chickens

Cited by 4 publications

References 16 publications

Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection

Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection

Immunological differences between layer- and broiler-type chickens

T lymphocyte responses are critical determinants in the pathogenesis and resistance to mycoplasma respiratory disease

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