The effect of rosuvastatin and atorvastatin on erectile dysfunction in hypercholesterolaemic patients

Abstract

Rosuvastatin showed no effect on erectile dysfunction, while we observed increased erectile dysfunction with atorvastatin. Our study reveals that different statin types may have different effects on erectile dysfunction.

The Effect of Statins on Erectile Dysfunction: A Meta‐Analysis of Randomized Trials

“…[22]. The percentage of persons with diabetes in this analysis is low because in three studies diabetes was an exclusion criterion [22,26,28]. When these studies, as well as those with missing information, were excluded, the percentage of patients with diabetes was 15.1%.…”

“…Eleven studies were used in the metaanalysis [20][21][22][23][24][25][26][27][28], including two reports that tested separate interventions [26,28]. Of the 11 randomized trials, seven were double-blind placebocontrolled [20][21][22]24,26,27], and four used no medication [23,25,28] as the control. The three observational studies were not included in the primary analysis [18,29,30].…”

Improvement in erectile function in a rat model of high cholesterol diet-induced atherosclerosis by atorvastatin in a manner that is independent of its lipid-lowering property

“…Lipophilic statins, such as atorvastatin, could induce peripheral neuropathy in the penile nerves which would contribute to ED subsequently (Do, Huyghe, Lapeyre‐Mestre, Montastruc, & Bagheri, ). Notably, the studies reporting ED occurrence and statins use were followed up for a long duration, usually more than 6 months (Carvajal et al., ; Do et al., ; Nurkalem et al., ). Given the inconsistent data, the statins use and ED occurrence were not confirmed or might be a long‐term effect.…”

“…Phosphodiesterase type 5 inhibitor (PDE5i) is the first‐line treatment for ED through modulating nitric oxide (NO)‐cyclic guanosine monophosphate (cGMP) levels in cavernosum. However, the efficacy of PDE5i is lower in ED patients with some risk factors, including hyperlipidemia (Nurkalem et al., ), diabetes mellitus (Rendell, Rajfer, Wicker, & Smith, ), hypertension (Chrysant, ) and multiple sclerosis (Lew‐Starowicz & Gianotten, ).…”

Cardiovascular Risk Reduction and Male Sexual Health: No Free Ride

“…Conclusions from recent reports about the role of statins have ranged from cautious claims of a beneficial effect of statins on ED, to beneficial effects with some but not other statins, to neutral effects on ED but with beneficial effects on quality of life. [1][2][3][4][5][6][7][8] Similarly, although ED is commonly ascribed to b-blockers, centrally acting sympatholytic drugs, thiazide-class diuretics, and aldosterone receptor blockers, recent reports suggest that the b-blocker nebivolol with vasodilating properties might either help or not impair ED 9 ; and others suggest that when ED is of concern, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, or calcium channel blockers should be used preferentially 10 ; and still others suggest a rank order of preference of an angiotensin receptor blocker followed by consideration of either angiotensin converting enzyme inhibitors or calcium channel blockers. 11 Almost all of these reports and recommendations are plagued by the perniciousness of placebo as well as nocebo effects facilitated through ready access to sources of lay information provided in a fashion devoid of critical clinical appraisal or credible clinical expertise.…”