The Effect of Rosa Damascena Extract on Primary Dysmenorrhea: A Double-blind Cross-over Clinical Trial

Abstract

Background:Dysmenorrhea is one of the most common types of cyclic pain that affects 50% of women and girls in their menstrual ages. Because of the side-effects and contraindications of chemical medicines, using herbs has been investigated in treating dysmenorrhea.Objectives:The aim of this study was to determine the effect of Rosa damascena extract on primary dysmenorrhea among the students of Kowsar dormitory in Tabriz University of Medical Sciences.Materials and Methods:This study was performed in Iran on 92 single 18-24 year old students with BMI :19-25 and obtaining pain intensity score of 5-8 in Visual Analogue Scale that were randomly classified and included in two groups of 46 persons. The participants received two capsules of Mefenamic Acid and Rosa damascena with the similar physical properties in two consecutive cycles per 6 hours for 3 days in a cross-over form. The data were collected through the questionnaire of demographic characteristics and check-list of visual analogue scale. Descriptive statistics and repeated measurement test and independent samples t test by using SPSS (13/win) were used in order to determine and compare the effects of two drugs on dysmenorrheal pain intensity of the groups.Results:There was a significant difference between the average of pain intensity at different hours of measurement in each group after the end of first cycle and second cycle (P < 0.001). There was no significant difference between the average of pain intensity in two groups in the first cycle (P = 0.35) and second cycle (P = 0.22).Conclusions:In this study¸ Rosa damascena and Mefenamic acid had similar effects on pain intensity of primary dysmenorrhea . With further studies, Rosa damascena which has no chemical side effects¸ can be suggested for treating primary dysmenorrhea.

The Effect of Cinnamon on Menstrual Bleeding and Systemic Symptoms With Primary Dysmenorrhea

“…Therefore, cinnamon improves the severity of primary dysmenorrhea. This finding was consistent with the previous studies on the effects of herbal medicines such as cumin ( 16 ) thymus vulgaris , Achillea millefolium ( 17 ), fennel ( 18 ), Matricaria recutita ( 19 ), Rosa damascena extract ( 20 ), aromatherapy massage and Zingiber officinale ( 1 ) in treatment of dysmenorrhea.…”

“…On the other hand, this was the first clinical trial on the effects of cinnamon on menstrual bleeding and systemic symptoms including nausea and vomiting due to primary dysmenorrhea in female college students in Iran, which was the strength of this study. Some of the factors influencing pain intensity and other symptoms with primary dysmenorrhea such as culture, genetic and nutrition ( 20 , 31 ) were uncontrollable, which were the weak points of this study.…”

“…In addition, eugenol can prevent the biosynthesis of prostaglandins and reduce inflammation. Cinnamon contains a variety of vitamins such as vitamin A, thiamin, riboflavin, and ascorbic acid ( 20 ). In adults and adolescents, 1.5 - 4 g daily of dried bark cinnamon can be used.…”

Rose Mentioned in the Works of Scientists of the Medieval East and Implications in Modern Science

“…A is thought to be a major pathological cause of Alzheimer's disease. A (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), the major fragment of the full peptide Ab found in the brains of Alzheimer patients, causes neural cell death, neuritic atrophy, synaptic loss, and memory impairment [32].…”

The Effect of Hydro-Alcoholic Extract of Rosa damascena on Uterine Constriction of Virgin Rats

“…That is somewhat in contrast to earlier findings. Moreover, in a new study, the effect of R. damascena extract was studied on primary dysmenorrhea in 92 girls showing that the dietary extract of R. damascena and Mefenamic acid had similar effects on pain intensity of primary dysmenorrhea (17). R. damascena and its products like rose water are commonly used as air freshener and flavors.…”