The effect of resveratrol on the inflammatory response and delayed onset muscle soreness after a marathon in male athletes: a randomised, double-blind, placebo-controlled pilot study

Abstract

ObjectivesResveratrol, a natural polyphenolic flavonoid antioxidant is known to have numerous health benefits and to act as a potent anti-inflammatory substance. This study was undertaken to investigate the inflammatory responses and delayed onset of muscle soreness after the London Marathon, and whether it is altered by Resveratrol.Design and settingDouble placebo-controlled randomised trial conducted at the London Marathon, 2010.MethodsSeven healthy male athletes were recruited for the study. Participants were randomised to either Resveratrol or placebo. The Resveratrol group was treated with 600 mg Resveratrol daily for 7 days immediately before the marathon. Blood was taken 48 h before the marathon and 18–32 h after the marathon. Samples were analysed for white blood cell count (WBC) and C reactive protein (CRP). To assess delayed onset muscle soreness a visual analogue scale (VAS) score was taken at the same times as the blood samples. The prepost changes were compared between the groups using the Mann–Whitney U test.ResultsThere was no significant difference between the two groups in terms of changes occurring between pre and post-tests for WBC, CRP or VAS (p=0.857, 0.629 and 0.70 respectively).ConclusionThis pilot study could not find a difference in immune response or delayed onset of muscle soreness between Resveratrol and placebo after the London Marathon 2010. Further investigations are needed with longer treatment time and higher doses, analysing additional parameters like interleukins for a possible effect of Resveratrol on the inflammatory response due to extensive exercise.

Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery

“…A marathon race can evoke a profound systemic inflammatory response, evidence for which is provided by a number of studies that observed large systemic increases in cytokine and leucocyte activity (Suzuki et al 2003;Howatson et al 2010;Scherr et al 2011;Laupheimer et al 2014). Thus, it would be reasonable to assume that an intervention targeting the acute inflammatory response might help to minimize secondary muscle damage, which, in turn, might accelerate the recovery process after a marathon race.…”

Antioxidants for preventing and reducing muscle soreness after exercise: a Cochrane systematic review

“…All 50 studies were randomised controlled trials; no quasirandomised controlled trials met the inclusion criteria. Thirty-eight trials (with a total of 901 participants) employed a parallel design 21 22 27–60. The other 12 trials (with a total of 188 participants) employed a crossover design 61–72…”

“…Seven trials were designed to produce DOMS under field-based conditions,22 35 44–46 64 and the other 43 studies were designed to produce DOMS under laboratory-based conditions. In all trials, an antioxidant supplement was compared with a placebo.…”

Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease

“…Эти данные могут объяснять отсутствие влияния ресвератрола на сигнальную трансдукцию по NF-kB пути в отдельных исследованиях с участием здоровых лиц, но и определяют профиль его безопасности [23].…”