The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats

Wu, Lina; Zhang, Yinghui; Ma, Xiaokun; Zhang, Na; Qin, Guijun

doi:10.1007/s11033-012-1780-z

Cited by 84 publications

(59 citation statements)

References 26 publications

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“…Deacetylation of FOXO1 by SIRT1 increased starvation-induced autophagy in cardiac myocytes (97). Consistent with this study, treatment with the SIRT1 activator, resveratrol, significantly increased FOXO1 activity in diabetic kidney, attenuating diabetes-induced oxidative stress and fibrosis (98).…”

Section: Sirt1 Induces Autophagy By Targeting Autophagy-related Genessupporting

confidence: 85%

Sirtuin 1: A Target for Kidney Diseases

Kong

Zhou

et al. 2015

Mol Med

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Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD + -dependent histone deacetylase that is necessary for caloric restriction-related lifespan extension. SIRT1, as an intracellular energy sensor, detects the concentration of intracellular NAD + and uses this information to adapt cellular energy output to cellular energy requirements. Previous studies on SIRT1 have confirmed its beneficial effects on cellular immunity to oxidative stress, reduction of fibrosis, suppression of inflammation, inhibition of apoptosis, regulation of metabolism, induction of autophagy and regulation of blood pressure. All of the above biological processes are involved in the pathogenesis of kidney diseases. Therefore, the activation of SIRT1 may become a therapeutic target to improve the clinical outcome of kidney diseases. In this review, we give an overview of SIRT1 and its molecular targets as well as SIRT1-modulated biological processes, with a particular focus on the role of SIRT1 in kidney diseases.

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Section: Sirt1 Induces Autophagy By Targeting Autophagy-related Genessupporting

confidence: 85%

Sirtuin 1: A Target for Kidney Diseases

Kong

Zhou

et al. 2015

Mol Med

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“…Notably, overexpression of the constitutively nuclear form of FoxO1 inhibited insulin-induced suppression of PGC-1α gene transcription, and mutations of 3 IREs abolish or blunt activity of the PGC-1α promoter [18] . Furthermore, we showed recently that FoxO1 expression and activity significantly decreased in the kidneys of DN rats and in rat kidney MCs in response to high-glucose conditions [19,20] . However, the protective roles of FoxO1 and PGC-1α against oxidative stress in the kidneys during DN have not been characterized.…”

Section: Introductionmentioning

confidence: 91%

Activation of FoxO1/ PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats

Wang

Guo

et al. 2015

Molecular and Cellular Endocrinology

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“…Also, RSV treatment alleviates vasculopathy induced by diabetes through attenuating the AGE/receptor for AGE/NF-kB signaling pathway [54] In experimentally induced diabetes by STZ, treatment with the sirtuin agonist RSV significantly increased expression of Sirt1 with concomitant significant increase of FoxO1 activity in diabetic kidney as well as reversed the collagen IV and fibronectin protein levels and improved kidney pathological [55]. The mechanism of Sirt 1 activation by RSV relays on the activation of AMPK and this was induced through inhibition of phosphodiesterase-4 and c AMP elevation [56].…”

Section: Tablementioning

confidence: 99%