The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results

Gal, Roland; Deres, László; Tóth, Kálmán; Halmosi, Róbert; Habon, Tamás

doi:10.3390/ijms221810152

Cited by 51 publications

(44 citation statements)

References 187 publications

(250 reference statements)

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“…Resveratrol (Re; 3,5,4′-trihydroxy-trans-stillbene), is a naturally occurring polyphenol found mainly in in the skin of grapes, in berries, and peanuts. Re has been studied for its pharmacological effects, including antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, anti-cancer, anti-atherosclerotic, and anti-diabetic properties [ 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

et al. 2021

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Cadmium (Cd) represents a public health risk due to its non-biodegradability and long biological half-life. The main target of Cd is considered the kidney, where it accumulates. No effective treatment for Cd poisoning is available so that several therapeutic approaches were proposed to prevent damages after Cd exposure. We evaluated the effects of a flavonoid-rich extract of bergamot juice (BJe), alone or in association with curcumin (Cur) and resveratrol (Re), in the kidney of mice exposed to cadmium chloride (CdCl2). Male mice were administered with CdCl2 and treated with Cur, Re, or BJe alone or in combination for 14 days. The kidneys were processed for biochemical, structural and morphometric evaluation. Cd treatment significantly increased urea nitrogen and creatinine levels, along with tp53, Bax, Nos2 and Il1b mRNA, while reduced that of Bcl2, as well as glutathione (GSH) content and glutathione peroxidase (GPx) activity. Moreover, Cd caused damages to glomeruli and tubules, and increased Nrf2, Nqo1 and Hmox1 gene expression. Cur, Re and BJe at 40 mg/kg significantly improved all parameters, while BJe at 20 mg/kg showed a lower protective effect. After treatment with the associations of the three nutraceuticals, all parameters were close to normal, thus suggesting a new potential strategy in the protection of renal functions in subjects exposed to environmental toxicants.

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Section: Introductionmentioning

confidence: 99%

Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

et al. 2021

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“…The key results reported were that FMD was considerably augmented in female but not male patients administered trans-resveratrol. These results suggest that hypertensive patients with endothelial dysfunction, mainly women and those with high LDL-c, showed an improvement in endothelial function with a single dose of trans-resveratrol, although there were no significant improvements in peripheral and central BP ranges [27,109].…”

Section: Resveratrolmentioning

confidence: 82%

Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease

et al. 2021

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Background: The blockade of the progression or onset of pathological events is essential for the homeostasis of an organism. Some common pathological mechanisms involving a wide range of diseases are the uncontrolled inflammatory reactions that promote fibrosis, oxidative reactions, and other alterations. Natural plant compounds (NPCs) are bioactive elements obtained from natural sources that can regulate physiological processes. Inflammation is recognized as an important factor in the development and evolution of chronic renal damage. Consequently, any compound able to modulate inflammation or inflammation-related processes can be thought of as a renal protective agent and/or a potential treatment tool for controlling renal damage. The objective of this research was to review the beneficial effects of bioactive natural compounds on kidney damage to reveal their efficacy as demonstrated in clinical studies. Methods: This systematic review is based on relevant studies focused on the impact of NPCs with therapeutic potential for kidney disease treatment in humans. Results: Clinical studies have evaluated NPCs as a different way to treat or prevent renal damage and appear to show some benefits in improving OS, inflammation, and antioxidant capacity, therefore making them promising therapeutic tools to reduce or prevent the onset and progression of KD pathogenesis. Conclusions: This review shows the promising clinical properties of NPC in KD therapy. However, more robust clinical trials are needed to establish their safety and therapeutic effects in the area of renal damage.

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“…In addition to the beneficial effects of RESV discussed in our study, it has proven to be cardioprotective in many other ways. RESV modulates the renin-angiotensin system and enhances the production of nitrogen monoxide (NO), thus proved to be effective in the pathomechanism of hypertension, atherosclerosis, or ischemic heart disease [ 38 , 39 ]. Growing evidence support that RESV exerts its cardioprotective effect by reducing oxidative stress and inflammation, improving Ca 2+ homeostasis and decreasing cardiomyocyte apoptosis [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Börzsei

Sebestyén

Szabó

et al. 2022

Oxidative Medicine and Cellular Longevity

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According to a widely accepted theory, oxidative stress is considered to be the number one trigger of aging-associated degenerative processes including cardiovascular diseases. In the context of aging-research, resveratrol receives special attention with its surprising number of health benefits. The aim of our study was to examine the anti-inflammatory and antioxidant effects of this dietary polyphenol in aging rat heart. 20-month-old female and male Wistar rats were divided into control (untreated) and resveratrol-treated groups. Resveratrol was administered at a dose of 0.05 mg/ml for 12 weeks dissolved in drinking water, while the control rats received ad libitum water. Cardiac level of reactive oxygen species (ROS), nuclear factor kappa B (NFκB), tumor necrosis factor alpha (TNF-α), and glutathione (GSH) parameters, as well as the activity of myeloperoxidase (MPO) and heme oxygenase (HO) enzymes were detected. Together with the biochemical measurements, hearts were isolated and used for an exposure of ischemic-reperfusion injury via Langendorff perfusion system. 12 week of resveratrol treatment suppressed the age-related inflammatory pathways including the expression of TNF-α, NFκB, and the activity of MPO while intensified the endogenous antioxidant defenses through the induction of GSH and HO system. Presumably, as a result of these processes, the necrotic area of the heart in response to an acute injury was also significantly reduced in the resveratrol-treated groups. Our findings confirmed that resveratrol has cardioprotective effects at several points by counteracting the aging-associated cellular malfunctions in the heart.

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The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results

Cited by 51 publications

References 187 publications

Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms

Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

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