The effect of resistance training on clinical outcomes in heart failure: A systematic review and meta-analysis

Jewiss, Daniel; Ostman, Cecilia; Smart, Neil A.

doi:10.1016/j.ijcard.2016.07.046

Cited by 75 publications

(98 citation statements)

References 32 publications

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“…Increased risk of wait-list mortality (4) Cardiomyopathy Predisposition to infection (12) Increased posttransplant length of stay (52,53) LV dysfunction (63) Increased posttransplant mortality (53) Heart failure, preserved ejection fraction (7) Increased mortality following transplant (64) Management Diet (protein supplementation) (67) L-Carnitine (81) Diet Exercise (77) Exercise (83,84) Exercise (88,89) Ongoing studies…”

Section: Discussionmentioning

confidence: 99%

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Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

2019

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Sarcopenia is a common complication of cirrhosis and is defined as a progressive and generalized loss of skeletal muscle mass, strength, and function. Sarcopenia is associated with poor prognosis and increased mortality. How sarcopenia and muscle wasting relate to such poor outcomes requires looking beyond the overt muscle loss and at this entity as a systemic disease that affects muscles of vital organs including cardiac and respiratory muscles. This review explores the pathophysiological pathways and mechanisms that culminate in poor outcomes associated with sarcopenia. This provides a launching pad to identify potential targets for therapeutic intervention and optimization to improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

“…Exercise training is known to benefit cardiovascular function. Aerobic or resistance training has been shown to improve both exercise tolerance and QOL in patients with heart failure . Studies have shown an increase in skeletal muscle ErbB3 expression with resistance training, leading to improved cardiac function …”

Section: Managementmentioning

confidence: 99%

Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

2019

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“…40 The failure of this form of exercise to attenuate LV remodeling may be due to the increased pressure load associated with resistance exercise. 41,42 …”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update

Tucker

Beaudry

Liang

et al. 2019

Progress in Cardiovascular Diseases

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“…Therefore, another approach is required in frailty and HFpEF. A recent meta-analysis showed that resistance training was useful for improving exercise capacity and QOL in patients with HFrEF 24. There is no established evidence of resistance training in HFpEF.…”

Section: Treatment Of Frailty In Hfpefmentioning

confidence: 99%

The challenge of frailty and sarcopenia in heart failure with preserved ejection fraction

Kinugasa

Yamamoto

2016

Heart

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Frailty is a clinical state in which there is an increase in an individual's vulnerability for developing increased dependency and/or mortality when exposed to stressors. Frailty is often accompanied by heart failure with preserved ejection fraction (HFpEF), and frailty is likely to affect its clinical features and outcomes. Frail patients with HFpEF are frequently associated with sarcopenia (ie, muscle loss and weakness), which is a major component of the pathophysiology of frailty. Sarcopenia is a systemic skeletal muscle disease that impairs the function of limb skeletal muscles, as well as respiratory muscles, and this results in further functional decline. In addition, sarcopenia may contribute to cardiovascular remodelling and dysfunction, leading to the development of HFpEF through several metabolic and endocrine abnormalities. Although there is no established strategy for frail patients with HFpEF, a multidisciplinary approach, including various types of muscular training and nutritional intervention, may provide beneficial effects for these patients.

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The effect of resistance training on clinical outcomes in heart failure: A systematic review and meta-analysis

Cited by 75 publications

References 32 publications

Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease

Meta-analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-year Update

The challenge of frailty and sarcopenia in heart failure with preserved ejection fraction

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