The effect of resin infiltration on proximal caries lesions in primary and permanent teeth. A systematic review and meta-analysis of clinical trials

Chatzimarkou, Sofia; Koletsi, Despina; Kavvadia, Katerina

doi:10.1016/j.jdent.2018.08.004

Cited by 42 publications

(44 citation statements)

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“…Accordingly, timely systematic reviews on the clinical efficacy of this micro-invasive solution have confirmed its efficacy [6,7]. With observation periods of up to four years in a clinical trial [8], the resin infiltration of proximal enamel lesions would seem to complement (or even outperform) other interventions like fluoridation and improved interdental hygiene [6,9], even with high-risk caries patients [10,11].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Kielbassa¹,

Leimer²,

Hartmann³

et al. 2020

PLoS ONE

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This ex vivo proof-of-concept study aimed to investigate the effect of nanosilver particles (AgNP) added to a conventional infiltrant resin (Icon) on external penetration into natural proximal enamel caries exceeding into dentin after internal tunnel preparation and internal infiltration. Carious lesions (ICDAS codes 2/3) of extracted human (pre-)molars revealing proximal caries radiographically exceeding into dentin (E2/D1 lesions) were preselected. Then, 48 of those specimens showing demineralized areas transcending the enamel-dentin border as assessed by means of near-infrared light transillumination (DIAGNOcam) were deproteinized (NaOCl, 5%). Using an internal tunnel approach, occlusal cavities central to the marginal ridge were prepared. Excavation of carious dentin, total etch procedure (H 3 PO 4 , 40%), and internal resin infiltration (FITC-labeled) followed, along with final restorations (flowable composite resin). Outer lesion surfaces were etched (HCl, 15%) prior to external infiltration (RITC-labeled). Group 1 (control; n = 24) used non-modified infiltrant, while an infiltrant/ AgNP mixture (20 nm; 5.5 wt%) was used with experimental Group 2 (n = 24). Non-infiltrated pores of cut lesions were stained (Berberine), and specimens were analyzed using confocal laser scanning microscopy. Compared to the non-filled infiltrant, incorporation of AgNP had no effect on the resin's external penetration. Between the groups, no significant differences regarding internal or external infiltration could be detected, and non-infiltrated lesion areas did not differ significantly (p>0.109; t-test). The internal tunnel preparation in combination with both an internal resin infiltration and an additional external infiltration approach using a nanosilver-modified infiltrant resin leads to increased infiltrated lesion areas, thus occluding and adhesively stabilizing the porous volume of the demineralized enamel. While exerting antimicrobial effects by the nanosilver particles, this approach should have the potential as a viable treatment alternative for proximal lesions extending into dentin, thus avoiding the sacrifice of sound enamel, postponing the frequently inevitable restoration/re-restoration cycle of conventional proximal caries treatment, and improving dental health.

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Section: Introductionmentioning

confidence: 99%

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Kielbassa¹,

Leimer²,

Hartmann³

et al. 2020

PLoS ONE

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“…In ltration and sealing are frequently used as micro-invasion treatments. Recently, in ltration technology has been performed clinically for non-cavitated proximal caries [11,12]. This technique uses low-viscosity resin to occlude the micropores of non-cavitated proximal carious lesions [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…The procedure of sealing involves the application of a resin sealant, polyurethane tape or adhesives after tooth separation [19][20][21][22][23]. Previous systematic reviews and meta-analyses have shown that micro-invasive treatments are more effective than non-invasive treatments [3,11,[24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Infiltration and Sealing for Managing Non-Cavitated Proximal Lesions: A Systematic Review and Meta-Analysis

Chen¹,

Chen

Lin³

2020

Preprint

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Background: Infiltration and sealing are micro-invasive treatments for arresting proximal non-cavitated caries lesions; however, their efficacies under different conditions remain unknown. This systematic review and meta-analysis aimed to evaluate the caries-arresting effectiveness of infiltration and sealing and to further analyse their efficacies across different dentition types and caries risk levels.Methods: Electronic databases (Cochrane Library, PubMed and Embase) were searched for published literature, and references were manually searched. Split-mouth randomized controlled trials (RCTs) to compare the effectiveness between infiltration/sealing and non-invasive treatments in proximal lesions were included. The primary outcome was obtained from radiographical readings. In total, 995 citations were identified, and 16 RCTs (21 articles) were included.Results: For subgroup analysis, infiltration and sealing reduced the odds of lesion progression (infiltration vs non-invasive: OR = 0.20, 95% CI: 0.15 to 0.29; sealing vs placebo: OR = 0.27, 95% CI: 0.18 to 0.41). For both primary and permanent dentitions, infiltration and sealing were more effective than non-invasive treatments (primary dentition: OR = 0.30, 95% CI: 0.20 to 0.45; permanent dentition: OR = 0.19, 95% CI: 0.13 to 0.27). The overall effects of infiltration and sealing were significantly different from the control effects based on different caries risk levels (OR = 0.19, 95% CI: 0.14 to 0.27). For patients with different risk levels, there were significant differences between micro-invasive and non-invasive treatments (low risk: OR = 0.23, 95% CI: 0.07 to 0.75; low to moderate risk: OR=0.38, 95% CI: 0.18 to 0.81; moderate to high risk: OR=0.17, 95% CI: 0.17 to 0.29; and high risk: OR=0.14, 95% CI: 0.07 to 0.26). Infiltration was superior to non-invasive treatments for patients at different caries risk levels (low risk: OR = 0.07, 95% CI: 0.02 to 0.22; low to moderate risk: OR=0.38, 95% CI: 0.18 to 0.81; moderate to high risk: OR=0.19, 95% CI: 0.09 to 0.38; and high risk: OR=0.14, 95% CI: 0.07 to 0.29).Conclusion: Infiltration and sealing were more efficacious than non-invasive treatments for halting non-cavitated proximal lesions.

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“…A scientific study found that, compared to non-invasive methods (oral hygiene instructions), with resin infiltrant plus oral hygiene measures progression of proximal caries lesions was less likely to occur in permanent teeth after treatment [8]. A recent meta-analysis showed that preventing the progression of non-cavitated caries lesions by using resin infiltration is promising; thus, resin infiltration is proposed as an encouraging non-invasive approach that can be used as an option in addition to non-operative and operative approaches to treatment [9].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Resin Infiltration on the Progression of Proximal Caries Lesions: A Randomized Clinical Trial

Arslan¹,

Kaplan²

2019

Med Princ Pract

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The use of infiltrating resins is an efficient microinvasive treatment for interproximal caries in adolescents and young adults. • This method enables the treatment of lesions in a single session.• No significant adverse events or side effects were observed in patients 1 year following infiltration. AbstractObjective: The aim of this clinical trial was to assess the effect of resin infiltration on the progression of proximal caries lesions. Subjects and Methods: Forty-one patients, aged between 15 and 33 years, with 2 or more non-cavitated proximal caries lesions were included. In 41 of the adolescent and young adults, 45 pairs of proximal lesions with radiological extension into the inner and outer half of the enamel, or into the outer third of the dentin, were randomly allocated to the test groups (resin infiltration application + fluoridated toothpaste and flossing use) or to the control group (fluoridated toothpaste and flossing use). Standardized geometrically aligned digital bitewing radiographs were obtained using individual biting holders. The radiographic progression of the lesions was assessed after 1 year by digital-subtraction radiography. The McNemar test was used for statistical analysis. Results: In the test group 1/45 of the lesions (2.2%) and in the control group 9/45 of the lesions (20%) showed progression. The caries progression rate of the control group was significantly higher than that of the test group (p < 0.05). Conclusions: Resin infiltration of proximal caries lesions is effective in reducing progression of the lesion.

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The effect of resin infiltration on proximal caries lesions in primary and permanent teeth. A systematic review and meta-analysis of clinical trials

Cited by 42 publications

References 45 publications

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin

Infiltration and Sealing for Managing Non-Cavitated Proximal Lesions: A Systematic Review and Meta-Analysis

The Effect of Resin Infiltration on the Progression of Proximal Caries Lesions: A Randomized Clinical Trial

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