The effect of repeated vinyl chloride exposure on rat hepatic metabolizing enzymes

Du, Julie T.; Tseng, Michael T.; Tamburro, Carlo H.

doi:10.1016/0041-008x(82)90096-5

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Logistic regression analysis confi rmed that high levels of CYP2E1 mRNA increased the risk of liver abnormalities, and further suggested that older workers were less likely to present liver abnormalities. The latter effect may be partially explained by the fi ndings of Du et al [14] which indicate that VCM exposure, rather than causing enzyme induction, might increase the breakdown of CYP2E1 in long-term exposure. The presence of less susceptible workers, who are able to stay on the job for long periods of time, may also contribute to this effect.…”

Section: Genetic Polymorphisms and Liver Abnormalities In Vcm Workers Omentioning

confidence: 88%

CYP2E1 mRNA Expression, Genetic Polymorphisms in Peripheral Blood Lymphocytes and Liver Abnormalities in Chinese VCM-Exposed Workers

Wang¹,

Zhu²,

Qiu³

et al. 2008

International Journal of Occupational Medicine and Environmental Health

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Objective: To study the relationship between expression of cytochrome P4502E1 (CYP2E1) in human lymphocytes, variant CYP2E1 genotype, exposure to vinyl chloride monomer (VCM), and liver abnormalities in VCM-exposed workers. Methods: A case-control study was performed on 90 male occupationally exposed workers and 42 matched male nonexposed controls. Data were collected based on health surveillance, workplace investigation and questionnaire Survey. Total RNA and DNA were isolated from peripheral blood lymphocytes, and CYP2E1 mRNA expression was determined using RT-PCR, and the presence of CYP2E1 polymorphisms was identifi ed based on PCR-RFLP. Results: The mRNA expression of CYP2E1 in exposed workers (0.89±0.46) was signifi cantly higher than in nonexposed controls (0.61±0.35) (P < 0.01). Logistic regression analysis demonstrated a statistically signifi cant association between CYP2E1 mRNA expression levels and liver abnormalities in the VCM-exposed workers (OR = 3.66, P < 0.05). The genotype frequency for CYP2E1 variants among VCM-exposed workers was not signifi cantly different between workers with liver abnormalities and those without. Conclusions: Liver abnormalities in subjects exposed to VCM are positively associated with expression of peripheral blood lymphocyte mRNA, which is signifi cantly increased in exposed workers compared to nonexposed controls. Therefore, CYP2E1 mRNA levels may be useful for health surveillance and protection of VCM-exposed workers.

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Section: Genetic Polymorphisms and Liver Abnormalities In Vcm Workers Omentioning

confidence: 88%

CYP2E1 mRNA Expression, Genetic Polymorphisms in Peripheral Blood Lymphocytes and Liver Abnormalities in Chinese VCM-Exposed Workers

Wang¹,

Zhu²,

Qiu³

et al. 2008

International Journal of Occupational Medicine and Environmental Health

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“…For example, a recent issue of Toxicology and Applied Pharmacology includes papers relating to the inhalation toxicology of vinyl chloride [2], the organophosphorus insecticide fenitrothion [3], hydrogen fluoride [4], and the industrial solvents hexamethylphosphoramide [5] and trichloroethylene [6]. Rats were used in all but the trichloroethylene study, which utilized mice, and the exposure periods varied from 1 h for hydrogen fluoride to 24 months for hexamethylphosphoramide.…”

mentioning

confidence: 99%

Inhalation toxicology: Starting with the environment

Dorough

1982

Enviro Toxic and Chemistry

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-The theme of SETAC's Second Annual Meeting was Environmental Risk Assessment, with emphasis on the use of data in the risk assessment and overall decision making process for chemicals. Needs for specific types of data were emphasized by the theme of the meeting and in no area was the void more obvious than in inhalation toxicology. Sufficient information for decision making in this area simply is not available, and no better combination of expertise exists for making judgments of risk than that of the environmental and mammalian toxicologists. To foster further communication between the two, a symposium was held in which experienced mammalianoriented toxicologists were asked to address the state-of-the-art of inhalation toxicology for the benefit of those more oriented toward the traditional environmental toxicology area. Papers for the symposium are published herein to encourage continued efforts by all toxicologists to share in the data development and decision making process essential for healthy humans to enjoy a quality environment. The present paper is introductory in nature but utilizes recent findings in the author's laboratory concerning inhalation exposure and retention of chemical vapors in rats to demonstrate the rationale for selecting other topics for presentation.

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Effects of 1,2-dibromoethane on glutathione metabolism in rat liver and kidney

Mann

Darby

1985

Biochemical Pharmacology

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The effect of repeated vinyl chloride exposure on rat hepatic metabolizing enzymes

Cited by 5 publications

References 33 publications

CYP2E1 mRNA Expression, Genetic Polymorphisms in Peripheral Blood Lymphocytes and Liver Abnormalities in Chinese VCM-Exposed Workers

CYP2E1 mRNA Expression, Genetic Polymorphisms in Peripheral Blood Lymphocytes and Liver Abnormalities in Chinese VCM-Exposed Workers

Inhalation toxicology: Starting with the environment

Effects of 1,2-dibromoethane on glutathione metabolism in rat liver and kidney

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