The Effect of Renal Lymphatic Ligation on Kidney and Blood Pressure

Lilienfeld, Ralph M.; Friedenberg, Richard M.; Herman, John R.

doi:10.1148/88.6.1105

Cited by 6 publications

(2 citation statements)

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“…80 While the experimental setup used by Wilcox and colleagues in anesthetized rats 77 was unsuitable to track BP changes, ligation of all hilar and capsular lymphatics in 5 dogs acutely induced a transient 20 mm Hg increase in BP that gradually but incompletely returned toward baseline in 15 weeks. 81 Some degree of persisting systolic hypertension at that time cannot be excluded. Similarly, it is unknown whether these animals developed any salt sensitivity or if unresolved edema could slowly progress to interstitial fibrosis 82 and reduced creatinine clearance, as suggested in rats.…”

Section: Prototypic Interstitial Mechanophysiology Relevant To Hypert...mentioning

confidence: 99%

Sodium, Interstitium, Lymphatics and Hypertension—A Tale of Hydraulics

Rossitto,

Bertoldi,

Rutkowski

et al. 2024

Hypertension

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Blood pressure is regulated by vascular resistance and intravascular volume. However, exchanges of electrolytes and water between intra and extracellular spaces and filtration of fluid and solutes in the capillary beds blur the separation between intravascular and interstitial compartments. Contemporary paradigms of microvascular exchange posit filtration of fluids and solutes along the whole capillary bed and a prominent role of lymphatic vessels, rather than its venous end, for their reabsorption. In the last decade, these concepts have stimulated greater interest in and better understanding of the lymphatic system as one of the master regulators of interstitial volume homeostasis. Here, we describe the anatomy and function of the lymphatic system and focus on its plasticity in relation to the accumulation of interstitial sodium in hypertension. The pathophysiological relevance of the lymphatic system is exemplified in the kidneys, which are crucially involved in the control of blood pressure, but also hypertension-mediated cardiac damage. Preclinical modulation of the lymphatic reserve for tissue drainage has demonstrated promise and also generated conflicting results thus far. A better understanding of the hydraulic element of hypertension and the role of lymphatics in maintaining fluid balance can open new approaches to prevent and treat hypertension and its consequences, such as heart failure.

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Section: Prototypic Interstitial Mechanophysiology Relevant To Hypert...mentioning

confidence: 99%

Sodium, Interstitium, Lymphatics and Hypertension—A Tale of Hydraulics

Rossitto,

Bertoldi,

Rutkowski

et al. 2024

Hypertension

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“…The importance of renal lymphatics in fluid balance was demonstrated as early as the 1960s. Renal lymphatic ligation was reported to result in renal oedema, increased urine volume and, surprisingly, increased BP in several studies (Barer and Ward-Mcquaid, 1957;Lilienfeld et al, 1967). Zhang et al (2008) later demonstrated that dual renal lymphatic ligation was as detrimental to kidney function as a nephrectomy.…”

Section: Renal Lymphatics and Hypertensionmentioning

confidence: 99%

Immune cell trafficking, lymphatics and hypertension

Balasubbramanian

Gelston

Rutkowski

et al. 2018

British J Pharmacology

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Activated immune cell infiltration into organs contributes to the development and maintenance of hypertension. Studies targeting specific immune cell populations or reducing their inflammatory signalling have demonstrated a reduction in BP. Lymphatic vessels play a key role in immune cell trafficking and in resolving inflammation, but little is known about their role in hypertension. Studies from our laboratory and others suggest that inflammation-associated or induction of lymphangiogenesis is organ protective and anti-hypertensive. This review provides the basis for hypertension as a disease of chronic inflammation in various tissues and highlights how renal lymphangiogenesis is a novel regulator of kidney health and BP.

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