The effect of regular aerobic exercise on urinary brain-derived neurotrophic factor in children

Fediani, Yunita; Dewi, Masayu Rita; Irfannuddin, Irfannuddin; Saleh, Masagus Irsan; Dhaini, Safri

doi:10.14238/pi54.6.2014.351-7

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Aerobic exercise combined with locomotor stimulation could be the most suitable type of exercise to improve cognitive function. The gymnastic aerobic exercise, with fun and imaginative movements, has been proven to increase BDNF level among children [36]. Limitation of this study was the post-test only control group design, which MWMT was not assessed before the experiment.…”

Section: Discussionmentioning

confidence: 96%

Hurdle Aerobic Exercise Increases Angiogenesis and Neuroplasticity in the Hippocampus and Improves the Spatial Memory Ability of Middle-aged Mice

Irfannuddin¹,

Siagian²,

Jusman³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Complex aerobic exercise is believed to induce positive effects on neuron structure and cognitive function. Long-term and continual cognitive stimulation increases neuroplasticity by stimulating the synthesis of neuronal growth proteins and the formation of new synapses. Exercise also increases the ability of neurons to survive and improves brain vascularization. Further investigations should be conducted to explore what types of aerobic exercise are beneficial for cognitive function. AIM: This study investigated the effects of hurdle aerobic exercise on developmentally regulated brain protein-A (Drebrin-A) as a neuroplasticity indicator, and on vascular endothelial growth factor (VEGF) as an angiogenesis marker in the hippocampus. METHODS: This study was an experimental study with post-test only control group design. Thirty-three adult mice were divided into control, hurdle aerobic runner (HAR), and plain aerobic runner (PAR) groups (n = 11 for each group). Fiberglass running wheels were originally designed and modified to assemble hurdles inside with adjustable speed. Speed adaptation was intended to achieve aerobic intensity. The experiment was performed 5 times a week for 8 weeks. The Morris water maze test (MWMT) was used to assess spatial memory ability. One day after the last running exercise and final MWMT, the mice were sacrificed and the right side of the hippocampus was obtained for Drebrin-A analysis by enzyme-linked immunosorbent assay (ELISA). The entire right side brain tissue after hippocampus was removed then used for the neuroglobin ELISA assay. To analyze VEGF expression and calculation of blood vessel, the left side of the brain was prepared for hematoxylin eosin and immunohistochemistry staining. To assess the effect of exercise on vascular widening, the analysis of the slides was performed by calculating the percentage of blood vessels with diameters more than 15 μm. One-way ANOVA and Fisher’s least significant difference test was used for statistical analysis. RESULTS: There was a significant difference in the levels of Drebrin-A between the HAR and PAR groups. Both exercise groups had higher levels of Drebrin-A than the control group. HAR and PAR groups exhibited significantly higher percentages of blood vessels expressing VEGF in hippocampus compared to control. HAR and PAR groups had the higher percentages of larger vessels compare to control. There was no significant difference of neuroglobin levels among the three groups. Both the HAR and PAR groups exhibited better spatial memory than the control group. CONCLUSION: Both aerobic exercises induced positive effects on brain angiogenesis, while the intensity of aerobic exercises did not result in high hypoxic stress in the brain.

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Section: Discussionmentioning

confidence: 96%

Hurdle Aerobic Exercise Increases Angiogenesis and Neuroplasticity in the Hippocampus and Improves the Spatial Memory Ability of Middle-aged Mice

Irfannuddin¹,

Siagian²,

Jusman³

et al. 2020

Open Access Maced J Med Sci

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“…Also, physical activity increases the expression of growth factors, such as BDNF and VEGF. These factors promote the production of neurons and have an effect on cardiorespiratory indices and body composition (21,32,33); however, there are contradictions in the results (21).…”

Section: Discussionmentioning

confidence: 99%

Effects of 8-Week Anaerobic Gymnastics Training on Weight Loss and Related Growth Factors in Obese Children: A Clinical Trial

Saleh

Afroundeh²

2022

JPR

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Background: Overweight and obesity are prominent threats to pediatric health. The prevalence of childhood obesity has dramatically been increasing worldwide. Objectives: In this study, we analyze the effects of 8-week anaerobic gymnastic training on weight loss and related growth factors in obese children. Methods: In this clinical trial study, 30 obese elementary gymnasts in the age range of 8 to 12 years were randomly divided into control (n=15) and experimental (n=15) groups. The experimental group performed 45 minutes of anaerobic gymnastics training. Anthropometrical and body composition characteristics, maximal oxygen consumption, and the levels of brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor were measured before and after 8 weeks of training. Results: At the baseline, there were no significant differences for any of the dependent variables between the two groups (P≥0.05). After 8 weeks of training, values of weight, waist-hip ratio, body fat percentage, body fat weight, lean body weight, and maximal heart rate decreased significantly (P<0.05) while maximal oxygen consumption and BDNF increased significantly (P<0.05). Conclusions: We concluded that weight loss because of anaerobic gymnastic training may lead to a high serum concentration of BDNF. High BDNF may help in maintaining a reduced weight after intervention for obesity and may increase fat oxidation. The inhibitory effects of weight loss on vascular endothelial growth factor may have abolished the stimulatory effects of exercise and prevented a significant increase in the vascular endothelial growth factor level.

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“…The appropriate right exercise is with moderate intensity (6). Aerobic exercise has a positive effect on immunity and cognitive ability (7). Immunity can also be maintained by the good nutrients, rest, and reduce stress levels (8).…”

Section: Activitiesmentioning

confidence: 99%

Virtual national workshop: preparation of multimedia modules for physical education teachers in accordance with COVID-19 prevention procedures

Irfannuddin

Laeto

Zulissetiana

et al. 2021

Advances in Physiology Education

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The COVID-19 pandemic has caused changes in the school learning system. Face-to-face learning shifted to remote learning using multimedia approaches. Online learning created particular difficulties for Physical Education (PE) teachers. Previously, they had to be role models in the teaching of physical activity. A national virtual workshop was conducted to support those teachers as they shift to remote learning. The purpose of the workshop was to provide PE instruction through social media and develop online learning modules. The 3 days of activities consisted of 4 lectures and 6 workshops provided to 177 PE teachers from 32 provinces in Indonesia. Participants were informed about the COVID-19 pandemic, its impact on children, and healthy life during the pandemic. Online applications that were free of charge, easy to use, highly rated, and widely downloaded were also introduced to them. These multimedia applications could help teachers develop and deliver remote learning modules to their students. The workshop supported the teachers as they adapted to interactive distance learning. The workshop also successfully illustrates an innovative distance learning module delivered through multimedia.

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The effect of regular aerobic exercise on urinary brain-derived neurotrophic factor in children

Cited by 4 publications

References 22 publications

Hurdle Aerobic Exercise Increases Angiogenesis and Neuroplasticity in the Hippocampus and Improves the Spatial Memory Ability of Middle-aged Mice

Hurdle Aerobic Exercise Increases Angiogenesis and Neuroplasticity in the Hippocampus and Improves the Spatial Memory Ability of Middle-aged Mice

Effects of 8-Week Anaerobic Gymnastics Training on Weight Loss and Related Growth Factors in Obese Children: A Clinical Trial

Virtual national workshop: preparation of multimedia modules for physical education teachers in accordance with COVID-19 prevention procedures

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