The effect of refractive error on pattern electroretinograms in primates

Siegel, Marc J.; Marx, Marcia S.; Bódis-Wollner, Iván; Podos, Steven M.

doi:10.3109/02713688609020041

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…On the other hand, there was a decrease in both amplitudes of the pattern ERG response with PG. Although no electrophysiological studies used CLs of similar design, these results are consistent with previous findings of a decreasing pattern ERG amplitude with increasing blur level [39,[47][48][49][50]. The ganglion cells, whose activity is obtained from pattern ERG records, are sensitive to changes in contrast.…”

Section: Functional Changes-erg Findingssupporting

confidence: 90%

Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens

Amorim‐de‐Sousa

Pauné

Silva-Leite

et al. 2023

JCM

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Purpose: The axial elongation in myopia is associated with some structural and functional retinal changes. The purpose of this study was to investigate the effect of a contact lens (CL) intended for myopia control on the choroidal thickness (ChT) and the retinal electrical response. Methods: Ten myopic eyes (10 subjects, 18–35 years of age) with spherical equivalents from −0.75 to −6.00 diopters (D) were enrolled. The ChT at different eccentricities (3 mm temporal, 1.5 mm temporal, sub-foveal ChT, 1.5 mm nasal, and 3 mm nasal), the photopic 3.0 b-wave of ffERG and the PERG were recorded and compared with two material-matched contact lenses following 30 min of wear: a single-vision CL (SV) and a radial power gradient CL with +1.50 D addition (PG). Results: Compared with the SV, the PG increased the ChT at all eccentricities, with statistically significant differences at 3.0 mm temporal (10.30 ± 11.51 µm, p = 0.020), in sub-foveal ChT (17.00 ± 20.01 µm, p = 0.025), and at 1.5 mm nasal (10.70 ± 14.50 µm, p = 0.044). The PG decreased significantly the SV amplitude of the ffERG photopic b-wave (11.80 (30.55) µV, p = 0.047), N35-P50 (0.90 (0.96) µV, p = 0.017), and P50-N95 (0.46 (2.50) µV, p = 0.047). The amplitude of the a-wave was negatively correlated with the ChT at 3.0T (r = −0.606, p = 0.038) and 1.5T (r = −0.748, p = 0.013), and the amplitude of the b-wave showed a negative correlation with the ChT at 1.5T (r = −0.693, p = 0.026). Conclusions: The PG increased the ChT in a similar magnitude observed in previous studies. These CLs attenuated the amplitude of the retinal response, possibly due to the combined effect of the induced peripheral defocus high-order aberrations impacting the central retinal image. The decrease in the response of bipolar and ganglion cells suggests a potential retrograde feedback signaling effect from the inner to outer retinal layers observed in previous studies.

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Section: Functional Changes-erg Findingssupporting

confidence: 90%

Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens

Amorim‐de‐Sousa

Pauné

Silva-Leite

et al. 2023

JCM

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“…Previous studies have shown that amplitude, more than phase, is significantly affected by optical defocus. 18,20-22 In addition, it has been shown that scatter has significant detrimental effects on outcomes beyond those of blur, an issue relevant to patients developing age-related cataract where both scatter and blur can lead to a significant reduction in visual acuity18. Our results showed that the effect of optical defocus on PERG amplitude is significant at defocus greater than -2 diopters and +3 diopters and that the effect of defocus on phase is minimal.…”

Section: Discussionmentioning

confidence: 54%

Effect of Operator and Optical Defocus on the Variability of Pattern Electroretinogram Optimized for Glaucoma Detection (PERGLA)

Vizzeri

Tafreshi

Weinreb

et al. 2010

Journal of Glaucoma

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Purpose-To evaluate the effect of operator and optical defocus on the variability of Pattern Electroretinogram Optimized for Glaucoma Detection (PERGLA).Methods-Two different operators obtained two PERGLA recordings each from 10 healthy participants (5 women, mean age 32.1±10.3 years). In addition, one of the operators obtained recordings in which corrective lenses of various diopters (±0.5, ±1, ±2, ±3) were used to generate optical defocus in both eyes. The effect of operator on PERGLA amplitude and phase variability was determined using a single nested variance components' analysis model and by using Bland-Altman plots. One-way analysis of variance (ANOVA) was used to determine the effect of optical defocus on amplitude and phase.Results-Differences in measurements between operators accounted for approximately 26.6% and 18.2% of the total variance for amplitude and phase, respectively. Results were confirmed by the use of Bland-Altman plots. ANOVA identified a significant effect of defocus on mean amplitude (F= 2.65, p=0.01), but not phase (F=1.02, p=0.42). Conclusions-Measurementsobtained by different operators can result in significant differences in PERGLA amplitude. In addition, although optical defocus leads to a decrease in PERGLA amplitude by reducing visual acuity, this can be avoided by obtaining J1 or better vision before testing.

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“…Animal models have also been included in these reports, but their use as models seem valid as their peaks fall in the same TF range as those reported from human subjects. In rat, the peak seems to be between 8 and 12 rps (Berardi et al, 1990), and in macaque, it is reported to be 12 rps (Siegel et al, 1986). In humans, there is slightly higher variability, as reported peaks have consisted of approximately 4.8 rps (Brannan et al, 1992) and 11.1 -16.2 rps (Heine & Meigen, 2004), while another report indicates a peak of 10 rps that occurred for N95 only, with no peak shown in P50 (Berninger & Schuurmans, 1985).…”

Section: Temporal Frequencymentioning

confidence: 95%

“…One of the major disputes in the literature is the number of peaks seen in the curve derived from amplitude plotted as a function of TF. Some reports give evidence for one peak at a somewhat lower TF (Berardi et al, 1990;Berninger & Schuurmans, 1985;Brannan, Bodis-Wollner, & Storch, 1992;Heine & Meigen, 2004;Siegel, Marx, Bodis-Wollner, & Podos, 1986), whereas others have found two different peaks, with one being a lower TF and the other being a higher TF, with a dip in amplitude occurring between the two peaks (Falsini & Porciatti, 1996;Hess & Baker, 1984;Odom, Maida, & Dawson, 1982;Porciatti & Sartucci, 1996).…”

Section: Temporal Frequencymentioning

confidence: 98%

“…Others, however, indicate that both peaks occur at higher TFs, with the first peak being in the range of 12 -24 rps and the second peak in the range of 32-40 rps, and an absolute cutoff between 50 and 60 rps (Falsini & Porciatti, 1996;Porciatti & Sartucci, 1996). It is possible that this variability (both regarding the number of peaks reported as well as the discrepancies as to what those peaks may be) might be related to the fact that these studies used very different ranges of spatial frequencies in their stimuli, as there is a growing body of evidence that suggests the presence of an interaction between TF and spatial frequency (Berninger & Schuurmans, 1985;Heine & Meigen, 2004;Hess & Baker, 1984;Siegel et al, 1986).…”

Section: Temporal Frequencymentioning

confidence: 99%

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Impact of luminance and spatial parameters on the generation of the human pattern electroretinogram.

Godwin¹

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who were pivotal in applying this research to the glaucoma population. This particular effort was also aided by the entire staff of the Kentucky Lions Eye Center, to whom I am also indebted. Dr. Jonathan Nussdorf acted as an additional resource for understanding this patient population, and I am appreciative of the time and expertise he offered in planning the design of the third experiment. I am also grateful for the assistance of Dr. Thomas Roussel, who so graciously offered his time and knowledge to improve the programs written for these experiments and decrease the electrical noise of the recording area. Further, I wish to thank both past and current lab mates, Pan Shi and Eleanor O'Keefe, for their support, encouragement, and friendship. Finally, I would also like to extend my thanks to all participants of this study for making this research possible.

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The effect of refractive error on pattern electroretinograms in primates

Cited by 7 publications

References 5 publications

Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens

Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens

Effect of Operator and Optical Defocus on the Variability of Pattern Electroretinogram Optimized for Glaucoma Detection (PERGLA)

Impact of luminance and spatial parameters on the generation of the human pattern electroretinogram.

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