Background and objectives: Breast hypertrophy can cause a wide range of symptoms and affect the lifestyle and quality of life. The most common physical complaints include neck and upper back pain, shoulder pain, headache, painful shoulder grooves, low back pain, intertrigo of the inframammary crease, mastalgia, poor posture, and difficulty exercising. The cosmetic and psychological impacts of macromastia include being unable to find fitting clothes and low self-esteem. Breast reduction is the most effective treatment to improve these complaints, Methods: This prospective study was performed on 108 patients with breast hypertrophy associated with various physical signs and symptoms that affected the quality of life and the psychological state of the patients. Reduction mammoplasty was done for these patients using a different kind of techniques. Demographic data, specific symptoms questionnaire, data from the surgical procedure, and complications were recorded and collected before the operation and three months and one year later. Results: A hundred and eight patients with breast hypertrophy were treated surgically by reduction mammoplasty using different types of inverted T techniques from October 2008-September 2019. The mean age of patients was 38.6 (13-59 years). All patients are satisfied and described significant improvements in the symptoms and selfbody image. Postoperative complications include asymmetry (11patients), infection (2 patients), and poor scarring (6 patients). Conclusions: Breast reduction is highly efficient in resolving symptoms and in improving health-related quality of life. It leads to a high level of satisfaction and improvement of the patient's physical and psychosocial well-being.