The effect of Raphanus sativus and Pachyrhizus erosus juice combination  on the ethanol-induced gastric of mice

Pertiwi, Reza; Hanuun, Aanisah; Kurniawati, Noval; Khodijah, Petri Siti; Lestari, Dwi Indah; Fitriani, Dyah; Notriawan, Doni

doi:10.12928/pharmaciana.v11i3.20104

Cited by 4 publications

(6 citation statements)

References 11 publications

(14 reference statements)

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“…The results of the phytochemical screening test of the Chromolaena odorata L. plant showed that it contained secondary metabolites, namely flavonoids, alkaloids, tannins, saponins, and steroids (Munte et al, 2016;Frastika et al, 2017;Sirinthipaporn et al, 2017). According to research conducted by Pertiwi et al (2021), the tubers juice of Pachyrhizus erosus L. at a dose of 300 mg/kg BW gave a better gastroprotective effect than the juice of Pachyrhizus erosus L. tubers combined with the juice of Raphanus sativus L. at the same dose.…”

Section: Resultsmentioning

confidence: 99%

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Gastroprotective Effects of the Combination of Chromolaena odorata L. and Pachyrhizus erosus L. Extracts on Rats with Gastric Ulcer Model

Pertiwi

Rahmawati

Hanuun

et al. 2023

J.Pharm.Sci.Community

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Gastroprotective effects are caused by compounds that can protect the gastric mucosa. Gastroprotective activity provided by plants is due to the presence of a group of secondary metabolite compounds found in the plants. The types of secondary metabolite compounds are flavonoids, tannins, alkaloids and saponins. Chromolaena odorata L. contains tannins, phenols, flavonoids, saponins and steroids, while Pachyrhizus erosus L. is known to contain flavonoids and saponins. This study aimed to determine the gasprotective activity of the combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts in ethanol-induced rats by observing the parameters of the number of peptic ulcers, protection ratio, and images of gastric histopathology. The research method was to make a combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts which were given to six treatment groups: normal group without treatment; negative control group; positive control group given sucralfate; and three groups given a combination treatment of Chromolaena odorata L. and Pachyrhizus erosus L. extract with a dose of 100, 200, and 400 mg/kgBW. Treatment was done by oral administration for 14 days. On Day 14, after one hour of treatment, 96% ethanol induction was given orally at a dose of 2 ml/200 gBW except for the normal group. The ulcer index produced by negative control, positive control, the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.49; 1.64; and 0.78, respectively. The combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts can prevent gastric damage in rats caused by ethanol induction.

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Section: Resultsmentioning

confidence: 99%

“…Ecchymoses are bleeding spots of 0.2-3.0 cm. Purpura is a bleeding spot of >3 cm (Pertiwi et al, 2021).…”

Section: Macroscopic Observation Of Gastric Ulcermentioning

confidence: 99%

Gastroprotective Effects of the Combination of Chromolaena odorata L. and Pachyrhizus erosus L. Extracts on Rats with Gastric Ulcer Model

Pertiwi

Rahmawati

Hanuun

et al. 2023

J.Pharm.Sci.Community

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“…Pertiwi and Saputra (2019) where the administration of tuber juice Pachyrhizus erosus L. can reduce the number of ulcers that form and improve gastric histopathology due to ethanol exposure. Giving tuber juice Pachyrhizus erosus L.with a dose of 300 mg/kgBW gave a better gastroprotective effect than the juice of yam tubers combined with Raphanus sativus L.juice with the same dose (Pertiwi et al, 2021). Pachyrhizus erosus is known to contain avonoids and saponins (Lukitaningsih, 2009).…”

Section: Resultsmentioning

confidence: 99%

Gastroprotective activities of Peperomia pellucida L. and Pachyrhizus erosus L. extracts combination on ethanol-induced rats

et al. 2022

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Gastroprotective is an effect caused by the compounds that have the capability of protecting the gastric mucosa. Peperomia pellucida plants contain alkaloids, avonoids, saponins, tannins, and terpenoids, while Pachyrhizus erosus contains avonoids, alkaloids, tannins, and saponins. Peperomia pellucida reportedly contains dillapiole compounds with a gastroprotective effect. Moreover, its isolation result from Pachyrhizus erosus indicates the presence of dulcitol, gentisic acid, and formononetin, which has antioxidant activity. This study aims to determine the gastroprotective effect of the combination of Peperomia pellucida and Pachyrhizus erosus extract on rats with gastric ulcer models by looking at the ulcer index, percentage of inhibition, and histopathology. The research method used in this study was by making a combination of Peperomia pellucida and Pachyrhizus erosus extract. The combined extract was then given to 5 treatment groups. Group I as a negative control, group II as a positive control was given sucralfate, groups III, IV, and V were given a combination of Peperomia pellucida and Pachyrhizus erosus extract of 100, 200, and 400 mg/kg BW. The treatment was given orally for 14 days, after one hour of treatment on the 14th day, 96% ethanol induction was given orally at a dose of 5 mg/kg BW. The animal dissection was performed 24 hours after the induction. The results from observations showed an increase in body weight before and after the treatment. The ulcer index produced by negative control, positive control in the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.42; 2.04; and 1.07. This study showed that the combination of Peperomia pellucida and Pachyrhizus erosus extract has a gastroprotective effect.

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“…Considering the antioxidant effects of P. erosus , the juice of the tuber has been evaluated as a preventive agent on alcohol-induced gastric ulcers in mice [ 105 ]. A high consumption of alcohol is known to impair the gastric mucosal barrier, causing extensive hemorrhagic injuries, an accumulation of oxidative stress, and increased inflammation [ 106 ].…”

Section: Bioactivities (In Vitro and In Vivo)mentioning

confidence: 99%

“…Different doses of juice from P. erosus and Raphanus sativus separately and in combination were given to mice in the experiments. Tuber juice from P. erosus was found to be the most effective in the prevention of gastric ulcers in histopathology and in index values of gastric ulcers [ 105 ].…”

Section: Bioactivities (In Vitro and In Vivo)mentioning

confidence: 99%

The Bioactivity and Phytochemicals of Pachyrhizus erosus (L.) Urb.: A Multifunctional Underutilized Crop Plant

2021

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Pachyrhizus erosus (L.) Urb. is an underutilized crop plant belonging to the Fabaceae family. In recent years, the plant received huge attention and was introduced in different countries owing to properties such as a high nutritional content, its nitrogen-fixing abilities, and different biological activities such as its antioxidant, immune modulation, anticancer, anti-diabetes, anti-osteoporosis, antiviral, and antiaging affects, among others. In this review, an attempt has been made to comprehensively compile the biological activities of the plant to provide a panoramic view of the current efforts and further directions, which may lead to the development of pharmacological applications. This information will be helpful in creating interest towards P. erosus and it may be useful in developing the plant for medical applications and/or as a functional food. More than 50 phytochemicals have been reported from the plant, which belong to different chemical classes such as triterpenoids, organic acid, flavonoids, and fatty acids. Numerous biological activities were reported from the plant through in vivo, in vitro, ex vivo, and human studies. However, well-defined clinical studies are still lacking for the establishment of any biological properties that could be further developed. Suggestions for the further development of P. erosus, according to current knowledge about the different biological properties, has also been provided.

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The effect of Raphanus sativus and Pachyrhizus erosus juice combination on the ethanol-induced gastric of mice

Cited by 4 publications

References 11 publications

Gastroprotective Effects of the Combination of Chromolaena odorata L. and Pachyrhizus erosus L. Extracts on Rats with Gastric Ulcer Model

Gastroprotective Effects of the Combination of Chromolaena odorata L. and Pachyrhizus erosus L. Extracts on Rats with Gastric Ulcer Model

Gastroprotective activities of Peperomia pellucida L. and Pachyrhizus erosus L. extracts combination on ethanol-induced rats

The Bioactivity and Phytochemicals of Pachyrhizus erosus (L.) Urb.: A Multifunctional Underutilized Crop Plant

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