The Effect of Rapeseed Oil on Reproduction and on the Composition of Rat Milk Fat

Beare, Joyce L.; Gregory, E. R. W.; Smith, David M.; Campbell, J. A.

doi:10.1139/o61-016

Cited by 21 publications

(3 citation statements)

References 7 publications

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“…Some authors have found a very small proportion of these fatty acids (3), as we did in milk fat from the beginning of the suckling period. Other authors have found a high proportion (25-30%) (2,25). The values we obtained in the middle o f the suckling period (10-12 days) are intermediate (10-15%) like the values of Dobidsova et al (8), and much higher than observed at the beginning o f the suckling period (less than 5 %, table I).…”

Section: Lipid Metabolism O F the Neonatecontrasting

confidence: 50%

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

Ricquier¹,

Hemon²

1976

Neonatology

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Gas-liquid chromatography analysis of triglyceride (TG) and phospholipid (PL) fatty acids was performed in several tissues of the rat during fetal and neonatal development and the effect of cretinism investigated. Liver and brown fat had a low TG content in the fetus, the TG of brown fat being characterized by a high proportion of saturated fatty acids; only saturated fatty acids were synthetized from glucose by brown fat fragments. The onset of suckling was followed by an immediate accumulation of TG in liver and brown fat, and the fatty acid pattern of these TG was modified, but in opposite directions; the proportion of arachidonic acid increased in the PL of all tissues. Propylthiouracil feeding of the mother from the day of birth induced an abnormal accumulation of TG in the brown adipose tissue of the rat by the time they had the syndrome of cretinism. The fatty acid pattern of these TG was similar to that of controls.

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Section: Lipid Metabolism O F the Neonatecontrasting

confidence: 50%

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

Ricquier¹,

Hemon²

1976

Neonatology

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“…They may be derived from the circulation or be the product of lipogenesis in the mammary gland itself. The incorporation of dietary fatty acids into milk lipids has been described previously in studies with a number of species including humans (Insull et al, 1959;Beare et al, 1961;De Man & Bowland, 1963;Tollerz & Lindberg, 1965;Smith et al, 1969;Scott et al, 1971;Mellies et al, 1979). Because of the presence of significant proportions of medium-chain fatty acids in the milk of the rat, this species was considered eminently suitable for further studies of the regulation of milk-fat composition.…”

Section: Discussionmentioning

confidence: 85%

Dietary regulation of mammary lipogenesis in lactating rats

Grigor¹,

Warren²

1980

Biochemical Journal

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The proportion of medium-chain fatty acids (C8:0, C10:0 and C12:0) in rat milk increased significantly between day 4 and day 8 of lactation and for the remainder of lactation these acids comprised 40-50mol% of the total fatty acids. The milk fatty acid composition from day 8 was markedly dependent on the presence of dietary fat and altered to include the major fatty acids of the fats (peanut oil, coconut oil and linseed oil). The distribution of fatty acids made within the gland, however, was independent of dietary lipid and C8:0, C10:0 and C12:0 acids accounted for over 70% of the fatty acids made. The rates of lipogenesis in both the mammary gland and liver determined in vivo after the administration of 3H2O were affected by the presence of dietary lipid. In the mammary gland the rate for rats fed a diet containing peanut oil for 7 days was only one fifth that for rats fed a fat-free diet. Coconut oil also suppressed lipogenesis. Both dietary fats also suppressed lipogenesis in the liver.

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“…To our knowledge, no one has previously analysed non-esterified fatty acids in rat milk. Several reports give information on the fatty acid composition of rat milk (Beare, Gregory, Smith & Campbell, 1961;Beare, 1961;Rees, Shuck & Ackerman, 1966;Glass, Troolin & Jennes, 1967; 654 1970…”

Section: Discussionmentioning

confidence: 99%

Rat mammary-gland acetyl-coenzyme A carboxylase. Interaction with milk fatty acids

Miller

Geroch

Levy

1970

Biochemical Journal

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1. Highly purified rat mammary-gland acetyl-CoA carboxylase was inhibited by milk obtained from rats 12h after their young were weaned. 2. All the inhibitory activity was found in the particulate fraction (R(105)) obtained on centrifuging the milk. It could be extracted from milk fraction R(105) with acetone and identified as a complex mixture of non-esterified fatty acids, present in high concentration (nearly 10mm) in the milk. 3. Inhibition of acetyl-CoA carboxylase was observed at low concentrations (0.2-20mum) of several of these fatty acids when fresh fully active enzyme was used. Enzyme that had been partly inactivated by aging, or by storing in the absence of citrate, was stimulated by low concentrations but inhibited by high concentrations of fatty acids. 4. Various experiments suggested that fatty acids produce irreversible inactivation of acetyl-CoA carboxylase. 5. The effects of palmitoyl-CoA on mammary-gland acetyl-CoA carboxylase were found to resemble those of fatty acids, except that palmitoyl-CoA was effective at lower concentration. 6. The effect of milk fraction R(105) was tested on six other enzymes previously shown to decline to various extents after weaning. Although several of these enzymes were affected by unfractionated milk fraction R(105), none was significantly inhibited by the acetone extract or by low concentrations of lauric acid. 7. The findings are consistent, both qualitatively and quantitatively, with a regulatory mechanism whereby milk fatty acids shut off fatty acid synthesis in the mammary gland after weaning by inhibiting acetyl-CoA carboxylase.

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The Effect of Rapeseed Oil on Reproduction and on the Composition of Rat Milk Fat

Cited by 21 publications

References 7 publications

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

A Study of Phospholipids and Triglycerides in Several Tissues of the Rat during Fetal and Neonatal Development

Dietary regulation of mammary lipogenesis in lactating rats

Rat mammary-gland acetyl-coenzyme A carboxylase. Interaction with milk fatty acids

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