The effect of radiotherapy on cardiac function

Dogan, Sait Mesut; Bilici, H.M.; Bakkal, H.; Aydın, Mustafa; Karabağ, Turgut; Sayın, Muhammet Raşit; Aktop, Ziyaettin

doi:10.1097/mca.0b013e32835115d6

Cited by 6 publications

(1 citation statement)

References 17 publications

(21 reference statements)

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“…The late effects of radiation-induced heart disease, including myocardial fibrosis, often manifest many years to decades after thoracic tumour radiation [78,79] and may be due to a variety of pathophysiological processes. These pathways have been previously reviewed [57,75], and can include radiation-induced vascular injury [80], thrombosis [81,82], myofibroblast activation, collagen deposition [57], myocardial ischaemia and cell death [72]. Following radiation, many profibrotic cytokines and factors have been implicated in the development of radiation-induced fibrosis [57], and these may serve as potential biomarkers to evaluate the radiation therapy fibrotic response.…”

Section: Effects On Fibrosismentioning

confidence: 99%

Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm?

Zhang

Szymanski²,

Bergom³

et al. 2021

Clinical Oncology

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Radiation therapy is a well-established approach for safely and non-invasively treating solid tumours and benign diseases with high precision and accuracy. Cardiac radiation therapy has recently emerged as a non-invasive treatment option for the management of refractory ventricular tachycardia. Here we summarise existing clinical and preclinical literature surrounding cardiac radiobiology and discuss how these studies may inform basic and translational research, as well as clinical treatment paradigms in the management of arrhythmias.

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Section: Effects On Fibrosismentioning

confidence: 99%

Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm?

Zhang

Szymanski²,

Bergom³

et al. 2021

Clinical Oncology

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show abstract

Evidence-Based Cardiovascular Management of Patients Receiving Radiotherapy to the Heart

Taylor

Evans

Roberts

2013

Evidence-Based Cardiology Consult

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Cardiovascular sequelae of radiation therapy

et al. 2014

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Radiotherapy (RT) is one of the main therapeutic options for malignancy treatment; nevertheless, RT is not free from side effects, including an increased risk for secondary neoplasms and other organs injury. Cardiovascular complications are the second most frequent fatal post-RT sequelae, which physicians should be aware of and ready to diagnose early and cure. This review therefore aims to examine epidemiology, pathogenesis and clinical dose-correlated manifestations of RT-induced cardiovascular disease. Future perspectives on screening, prevention and treatment are also provided.

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The effect of radiotherapy on cardiac function

Abstract: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT.

Cited by 6 publications

References 17 publications

Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm?

Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm?

Evidence-Based Cardiovascular Management of Patients Receiving Radiotherapy to the Heart

Cardiovascular sequelae of radiation therapy

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