The effect of radioiodine treatment on the diseased thyroid gland

Riley, Andrew; McKenzie, Gordon; Green, Victoria; Schettino, Giuseppe; England, Ruth; Greenman, John

doi:10.1080/09553002.2019.1665206

Cited by 19 publications

(27 citation statements)

References 122 publications

(38 reference statements)

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“…131 I-mediated cellular damage, and some studies observed a necrotic cellular death following high-dose 131 I treatment. 19 The exact mechanisms of cellular death of SKBR3 cell have not yet been fully elucidated. Further studies are needed to uncover this issue.…”

Section: Resultsmentioning

confidence: 99%

Uptake and effect of radioiodine exposure on SKBR-3 cell lines

et al. 2019

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Radioiodine has been known as an adjuvant therapy for thyroid cancer. Beside for thyroid cell, radioiodine is reported to be taken up by breast cell. It may be proposed as an alternative for breast cancer therapy. Objective: The study aim was to analyze an uptake of radioiodine and cell proliferation rate of breast cancer cell after the exposure of radioiodine. Methods: This study used SKBR-3 cell line as representative of Human Epidermal Growth Factor Receptor (HER2+) subtype. The cells were planted in DMEM medium added 10% fetal bovine serum (FBS), panstrep 1% and amphotericin B. The cells were grown until 80% confluent and then stripped. Subsequently the cells were sub-cultured on plates 12 and 6 wells respectively for measured uptake of radioiodine and cell proliferation rate after the exposure. Radioiodine uptake was calculated by sum efflux of 125 Iodine (125I) and the amount of uptake after the addition of 95% ethanol. Cell proliferation rate was measured by calculated by using clonogenic assay after iodine-131 (131I) exposure. Results: The average of iodine uptake was 194±50 cpm/106 cell. The average cell proliferation after radioiodine exposure was 54%±5%; Conclusions: Radioiodine is taken by SKBR-3 cells and it reduced cell proliferation rate. This finding shows an opportunity for radioiodine as an alternative therapy for breast cancer. Another studies are needed to understand of cell death the mechanism.

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Section: Resultsmentioning

confidence: 99%

Uptake and effect of radioiodine exposure on SKBR-3 cell lines

et al. 2019

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“…The autoantibodies' binding to their target antibody-dependent cell-mediated cytotoxicity, which may lead to intra-thyroidal inflammation with subsequent hypothyroidism. This process is not fully understood (Riley et al 2019), but its nature may be stochastic, not limited to threshold radiation doses (Nagayama 2018). On the other hand, relatively high radiation doses may induce autoimmune hyperthyroidism too; this complication is well-known but rare (appr.1%) in the radioiodine treatment of autonomous hyperfunctioning thyroid nodules (Dunkelmann 2004).…”

Section: Autoimmune Thyroiditismentioning

confidence: 99%

“…According to the International Classification of Diseases, 10th edition (WHO 2016), besides autoimmune thyroiditis (E.06.3), another cause of hypothyroidism (E3.09) is atrophy of the thyroid (E3.04). Atrophy of the thyroid and subsequent hypothyroidism is frequently observed in patients with Graves´ disease (autoimmune hyperthyroidism) or thyroid cancer as an obvious consequence of surgical resection of considerable portions of the thyroid ([near-] total thyroidectomy) with or without widespread destruction of thyroid tissue by radioiodine (iodine-131 [I-131]) (Chaker et al 2017;Riley et al 2019). Historically, other causes of thyroid atrophy have been rare; however, recently, thyroid atrophy has been described as a frequent side effect in a considerable proportion (ca.…”

Section: Thyroid Atrophymentioning

confidence: 99%

“…Above the threshold, cells and tissues tend to be more frequently and severely damaged, and to more often lose their function as the radiation dose increases. In a recent comprehensive review about the effects of I-131 radioiodine treatment of the diseased thyroid gland, Riley et al (2019) summarized, "I-131 induces cell death both by direct and indirect damage to thyrocyte DNA largely through apoptosis. Some studies, however, have described detailed findings of cell death by necrosis following I-131".…”

Section: Thyroid Atrophymentioning

confidence: 99%

“…There is clear evidence from medically-irradiated patients, survivors of the atomic bombing, and people affected by the Chernobyl reactor accident, that radiation exposure in childhood can cause thyroid cancer and benign thyroid nodules later in life (Ron and Brenner 2010;UNSCEAR 2011;Imaizumi et al 2017). Apart from that, autoimmune reactions involving the thyroid, thyroid atrophy, and hypothyroidism, may be induced by radiation exposure (Riley et al 2019). However, these radiation effects are not as well-documented as are radiation-induced cancer and nodular disease of the thyroid.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hypothyroidism after radiation exposure: brief narrative review

Reiners

Дрозд²,

Yamashita

2020

J Neural Transm

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The thyroid gland is among the organs at the greatest risk of cancer from ionizing radiation. Epidemiological evidence from survivors of radiation therapy, atomic bombing, and the Chernobyl reactor accident, clearly shows that radiation exposure in childhood can cause thyroid cancer and benign thyroid nodules. Radiation exposure also may induce hypothyroidism and autoimmune reactions against the thyroid, but these effects are less well-documented. The literature includes only a few, methodologically weak animal studies regarding genetic/molecular mechanisms underlying hypothyroidism and thyroid autoimmunity after radiation exposure. Rather, evidence about radiation-induced hypothyroidism and thyroid autoimmunity derives mainly from follow-up studies in patients treated with external beam radiotherapy (EBRT) or iodine-131, and from epidemiological studies in the atomic bombing or nuclear accident survivors. Historically, hypothyroidism after external irradiation of the thyroid in adulthood was considered not to develop below a 10–20 Gy dose threshold. Newer data suggest a 10 Gy threshold after EBRT. By contrast, data from patients after iodine-131 “internal radiation therapy” of Graves´ disease indicate that hypothyroidism rarely occurs below thyroid doses of 50 Gy. Studies in children affected by the Chernobyl accident indicate that the dose threshold for hypothyroidism may be considerably lower, 3–5 Gy, aligning with observations in A-bomb survivors exposed as children. The reasons for these dose differences in radiosensitivity are not fully understood. Other important questions about the development of hypothyroidism after radiation exposure e.g., in utero, about the interaction between autoimmunity and hypofunction, and about the different effects of internal and external irradiation still must be answered.

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“How Do You Feel About Dosimetry?” The Gretchenfrage of Radionuclide Therapy

Blaickner

2024

Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum

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Dosimetry is Radionuclide Therapy which is a topic often and sometimes even passionately debated among scientists. It revolves around the question whether dosimetry calculations are useful or even necessary and if the calculated values have any clinical significance or advantage for the patient.This article aims to give answers to these questions by systematically reviewing the different aspects of Radionuclide Therapy. First, the most important radionuclides, carrier molecules, and corresponding imaging techniques used in diagnosis and therapy are discussed in the ways they can be combined for theragnostic approaches. Furthermore, the different forms of dosimetry and their levels of detail are outlined including a precis on the physical and radiobiological dose quantities found in literature.Moving forward the evidence for dose-effect relationships is presented, i.e., quantifiable tissue responses as a function of the calculated radiation dose. This includes radiotoxicities of normal, healthy organs which cause an upper limit of the administered activity and are controlled very well. In the case of the kidney the toxicity by Radionuclide Therapy was successfully described via radiobiologic models.Regarding the dose-response of malignant tissue the data is not as comprehensive as in external beam radiotherapy; however, the few studies clearly indicate the existence of a mathematical relation for the mean absorbed dose as well as for more complex dose quantities.Finally, the results are discussed in the context of personalized medicine where the benefits and limits of dosimetry in Radionuclide Therapy are presented.

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The effect of radioiodine treatment on the diseased thyroid gland

Cited by 19 publications

References 122 publications

Uptake and effect of radioiodine exposure on SKBR-3 cell lines

Uptake and effect of radioiodine exposure on SKBR-3 cell lines

Hypothyroidism after radiation exposure: brief narrative review

“How Do You Feel About Dosimetry?” The Gretchenfrage of Radionuclide Therapy

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