The Effect of Radiation on Meningioma Volume Change

Hall, Jacob; Opalak, Charles; Carr, Matthew; Harris, T. J. R.; Broaddus, William C.

doi:10.1016/j.wneu.2021.06.080

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…Although long-term data are fundamentally important for meningiomas, given the advanced age of the patients included in this study, the follow-up horizon of the present study represents a clinically significant time span. The tumor control reported in our study is consistent with comparable studies ( 2 , 34 , 35 ). Kaul et al.…”

Section: Discussionsupporting

confidence: 93%

Robotic stereotactic radiosurgery for intracranial meningiomas in elderly patients: assessment of treatment efficacy and safety

Früh,

Bodnar,

Nachbar

et al. 2024

Front. Oncol.

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PurposeStereotactic radiosurgery (SRS) has been increasingly used to treat intracranial pathologies in elderly patients. The treatment efficiency of SRS has been demonstrated in meningiomas, with excellent local control. We aimed to analyze the safety of robotic SRS in elderly patients with meningiomas.MethodsWe searched for patients with suspected WHO °I meningioma ≥ 60 years old, who underwent CyberKnife (CK) SRS from January 2011 to December 2021. Tumor localization was categorized using the “CLASS” algorithmic scale. Tumor response was evaluated using the Response Assessment in Neuro-Oncology (RANO) criteria for meningiomas. Adverse effects were graded using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 and a cox regression was performed to investigate possible predictors.ResultsWe identified 82 patients with 102 CK-treated lesions that matched the criteria for the first SRS. The median age was 70 [IQR 64-75] years, and 24.3% of the patients were aged > 75 years. Multiple lesions (up to six) were treated in 14.1% of the SRS-sessions. A previous surgery was performed in 57.3% of lesions, with a median time interval of 41 [IQR 10 – 58] months between the initial surgical procedure and the SRS treatment. In 47.9% of cases, CLASS 3 meningiomas at high-risk locations were irradiated. Single fraction radiosurgery was applied to 62.5% of the lesions, while in the remaining cases multi-session SRS with three to five fractions was used. During the median follow-up period of 15.9 months, lesion size progression was observed in 3 cases. Karnofsky Performance Status (KPS) declined by ≥ 20 points in four patients. Adverse effects occurred in 13 patients, while only four patients had CTCAE ≥2 toxicities. Hereby only one of these toxicities was persistent. The occurrence of complications was independent of age, planned target volume (PTV), high-risk localization, and surgery before SRS.ConclusionThe data indicates that SRS is a safe, efficient, and convenient treatment modality for elderly patients with meningioma, even at high-risk locations

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Section: Discussionsupporting

confidence: 93%

Robotic stereotactic radiosurgery for intracranial meningiomas in elderly patients: assessment of treatment efficacy and safety

Früh,

Bodnar,

Nachbar

et al. 2024

Front. Oncol.

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“…Multiple studies have reported consistent rates and degrees of meningioma volume reduction after radiotherapy or radiosurgery, with ~30–35% 50 , 54 , 55 reduction in size largely occurring during the first two to three years after treatment. Neurological symptom improvement following radiotherapy has been reported in 23–89% of cases, 56–58 although surgery offers faster and more complete relief from symptoms secondary to meningioma mass effect and edema.…”

Section: External Beam Radiotherapymentioning

confidence: 96%

Radiotherapy and radiosurgery for meningiomas

Chen

Lucas

Magill

et al. 2023

Neuro-Oncology Advances

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Meningiomas comprise a histologically and clinically diverse set of tumors arising from the meningothelial lining of the central nervous system. In the past decade, remarkable progress has been made in deciphering the biology of these common neoplasms. Nevertheless, effective systemic or molecular therapies for meningiomas remain elusive and are active areas of preclinical and clinical investigation. Thus, standard treatment modalities for meningiomas are limited to maximal safe resection, radiotherapy, or radiosurgery. This review examines the history, clinical rationale, and future directions of radiotherapy and radiosurgery as integral and effective treatments for meningiomas.

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Radiotherapy for meningiomas

et al. 2022

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Meningiomas are the most common primary central nervous system neoplasm. Despite promising recent progress in elucidating the genomic landscape and underlying biology of these histologically, molecularly, and clinically diverse tumors, the mainstays of meningioma treatment remain maximal safe resection and radiation therapy. The aim of this review of meningioma radiotherapy is to provide a concise summary of the history, current evidence, and future for application of radiotherapy in meningioma treatment.

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The Effect of Radiation on Meningioma Volume Change

Cited by 6 publications

References 18 publications

Robotic stereotactic radiosurgery for intracranial meningiomas in elderly patients: assessment of treatment efficacy and safety

Robotic stereotactic radiosurgery for intracranial meningiomas in elderly patients: assessment of treatment efficacy and safety

Radiotherapy and radiosurgery for meningiomas

Radiotherapy for meningiomas

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