The Effect of Radiation on the Lung and Bronchial Tree

Boushy, Samuel F.; Helgason, Agust H.; North, Luceil B.

doi:10.2214/ajr.108.2.284

Cited by 26 publications

(4 citation statements)

References 2 publications

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“…These late pulmonary side-effects of mantle-field irradiation indicate that the pulmonary damage is confined mainly to the radiation portal with primary affection of the bronchial tree and less affection of the lung parenchyma outside the radiation portal. The lung function impairment is consistent with histopathological findings (3,27,28) and with radiographic observations which we have previously reported in the patients (29).…”

Section: Mantlefield Irradiationsupporting

confidence: 92%

Late effects on pulmonary function of mantle‐field irradiation, chemotherapy or combined modality therapy for Hodgkin's disease

Jensen¹,

Carlsen²,

Groth³

et al. 1990

European J of Haematology

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The aim of the present study was to assess late pulmonary sequelae after treatment for Hodgkin's disease with various treatment modalities. Pulmonary function was studied in 142 patients per median 8 years after treatment for Hodgkin's disease with mantle‐field irradiation (54 patients), chemotherapy (26 patients) or mantle‐field irradiation followed by chemotherapy (62 patients). Mantle‐field irradiation was associated with a primary obstructive and minor restrictive lung function impairment, whereas chemotherapy and combined modality therapy were associated with a restrictive lung function impairment. The number of patients with impaired lung function and the number of patients with complaints of dyspnea, however, were almost the same in the three treatment groups. 5% of the 142 patients had a pathologically low total lung capacity, i.e. values less than 2 standard deviations below predicted values. Pathologically low values of forced vital capacity and forced expiratory volume in 1 second were seen in 33% and 27% of the patients. 33% of the smokers (n = 80) had a pathologically low diffusion capacity in contrast to 8% of the non‐smokers (n = 62). Dyspnea on exertion was present in 24% of the 142 patients and was more frequent among patients with pulmonary functional abnormalities. In conclusion, late pulmonary sequelae after treatment for Hodgkin's disease do not provide a basis for choice between otherwise equally effective treatment regimes.

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Section: Mantlefield Irradiationsupporting

confidence: 92%

Late effects on pulmonary function of mantle‐field irradiation, chemotherapy or combined modality therapy for Hodgkin's disease

Jensen¹,

Carlsen²,

Groth³

et al. 1990

European J of Haematology

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“…The change in FEV1 has been variable, ranging from a small improvement to a mild decrease, with several studies showing no change [1,3,4]. Interestingly, a small study by BOUSHY et al [5] demonstrated an increase in FEV1 of 160 mL only in those patients who had severe baseline COPD (FEV1 f50% pred).…”

Section: To the Editorsmentioning

confidence: 99%

“…Treatment of multidrug-resistant (MDR) tuberculosis (TB) (defined as in vitro resistance to at least isoniazid and rifampicin, the two most potent first-line drugs for TB treatment) and extensively drug-resistant (XDR)-TB (defined as in vitro resistance to isoniazid and rifampicin plus any fluoroquinolone and at least one of the injectable drugs: amikacin, capreomycin or kanamycin) is still a major problem from both a clinical and a public health perspective [1][2][3][4][5].…”

Section: To the Editorsmentioning

confidence: 99%

Mechanisms of dyspnoea relief following radiation treatment in a patient with severe COPD

O'Meara¹,

Guenette²,

Raghavan³

et al. 2011

European Respiratory Journal

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“…Boushy et al, in a study of 42 patients with bronchogenic carcinoma treated by radiation, reported that radiation injury was more evident when the actual pathologic specimen was examined than could be determined from radiologic examination alone (73% versus 29% of cases). 6 Anecdotal reports by Koss' and Kato et a1.' described the radiation changes occurring in normal bronchial columnar cells.…”

mentioning

confidence: 97%

Cytomorphologic changes in split‐course radiation‐treated bronchogenic carcinomas

Albright

Hafiz

1988

Diagnostic Cytopathology

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The cellular changes produced by radiation therapy were studied in cytologic specimens from seven patients with bronchogenic carcinoma: squamous-cell carcinoma (four patients), adenocarcinoma (two patients), and small-cell undifferentiated carcinoma (one patient). Cytologic samples were obtained from sputum and bronchoscopic examination in patients before and after they received a course of radiation. The cells were studied by light microscopy. An increase in the percentage of columnar cells was detected in five of seven patients independent of the latency of cytologic sampling posttherapy. The percentage of macrophages was unchanged in patients sampled at 15, 18, and 24 mo after the last radiation dose; leukocytes were decreased in relative frequency in the majority of patients studied. Following irradiation, moderately atypical and severely atypical metaplastic cells were increased in relative frequency (48% versus 15% and 19% versus 3%, respectively) and malignant cells were decreased (40% versus 22%) or absent in all patients, irrespective of the type of carcinoma. Nuclear vacuolation, nuclear enlargement, loss of chromatin texture, and rupture of the chromatinic rim were seen in atypical and cancer cells. Infiltration of cancer cells by leukocytes was observed in two of four patients with squamous-cell carcinoma. In all treated patients, morphologic observations indicated that irradiation produces similar damage to "normal" bronchial epithelial cells although such changes are less apparent at longer time intervals following therapy.

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The Effect of Radiation on the Lung and Bronchial Tree

Cited by 26 publications

References 2 publications

Late effects on pulmonary function of mantle‐field irradiation, chemotherapy or combined modality therapy for Hodgkin's disease

Late effects on pulmonary function of mantle‐field irradiation, chemotherapy or combined modality therapy for Hodgkin's disease

Mechanisms of dyspnoea relief following radiation treatment in a patient with severe COPD

Cytomorphologic changes in split‐course radiation‐treated bronchogenic carcinomas

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