The effect of radiation in distraction osteogenesis for reconstruction of mandibular segmental defects

González-García, Raúl; Rodríguez-Campo, F.J.; Naval-Gías, Luis; Sastre-Pérez, Jesús; Díaz-González, F.J.

doi:10.1016/j.bjoms.2005.10.004

Cited by 29 publications

(8 citation statements)

References 7 publications

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“…Distraction osteogenesis of the irradiated craniofacial skeleton is rarely reported but has been successful in some cases (9, 20). In particular, Nolte et al presented successful DO in two adult patients with midface hypoplasia following radiation therapy during childhood (12).…”

Section: Discussionmentioning

confidence: 99%

Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone

Momeni

Rapp

Donneys

et al. 2016

Journal of Craniofacial Surgery

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The deleterious effects of radiotherapy, including hypovascularity and hypocellularity, have made distraction of irradiated bones challenging. Animal studies, however, have demonstrated adjunctive measures such as the administration of deferoxamine to significantly improve bone regeneration across irradiated distraction gaps. In this report, we demonstrate, for the first time, enhanced bone formation following deferoxamine application in a patient following distraction of a previously irradiated maxilla. CT imaging of the pterygomaxillary buttress on the side of administration revealed significantly increased bone area and density relative to the contralateral buttress. This is the first presentation of clinical deferoxamine use to promote bone formation following irradiated bone distraction and highlights the promise for this adjunctive measure to make outcomes after distraction of irradiated bone more reliable.

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Section: Discussionmentioning

confidence: 99%

Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone

Momeni

Rapp

Donneys

et al. 2016

Journal of Craniofacial Surgery

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“…Ainsi, les surfaces et les espaces de né oformation osseuse sont augmenté s. L'avantage de cette technique est de permettre la croissance du tissu osseux mais aussi des tissus mous avoisinants. La faisabilité de cette technique en tissu irradié a é té montré e chez l'homme [55,57]. Une ré gé né ration d'une perte de substance de 35 à 80 mm peut ê tre obtenue en 12 semaines en moyenne [57].…”

Section: Technique De Distractionunclassified

“…La faisabilité de cette technique en tissu irradié a é té montré e chez l'homme [55,57]. Une ré gé né ration d'une perte de substance de 35 à 80 mm peut ê tre obtenue en 12 semaines en moyenne [57]. Dans une é tude animale chez le mouton, Girod et al ont ré cemment obtenu une reconstruction efficace dans neuf dé fauts sur 20 pour les animaux non irradié s et neuf sur 12 pour les animaux irradié s en postopé ratoire.…”

Section: Technique De Distractionunclassified

Reconstruction mandibulaire en cancérologie : état actuel et perspectives

Jégoux

Bedfert

Alno

et al. 2009

Annales d'Otolaryngologie et de Chirurgie Cervico-faciale

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“…The main limitation of such techniques in these situations would come from the effects of radiotherapy, applied either before or after distraction, on the regenerated bone (7,8). …”

Section: Introductionmentioning

confidence: 99%

Lateral transport osteogenesis in maxillofacial oncology patients for rehabilitation with dental implants: a retrospective case series

Bilbao-Alonso¹,

García-Rielo²,

Varela‐Centelles³

et al. 2013

Med Oral

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Objectives: To report on the use of lateral transport osteogenesis in cancer patients after maxillo/mandibular resections and on the implant survival rate in the generated bone Material and Methods: Four patients treated using lateral transport osteogenesis entered this descriptive study and were retrospectively studied (mean age 55; range 41-62). Results: Reconstruction of segmentary defects after surgical and radiological cancer treatment on maxilla and mandible was achieved. No relevant intra- or post-operative complications occurred. No differences on implant survival were observed between patients who had received radiotherapy and those who had not. Conclusions: This approach can be considered a recommendable reconstructive option after oral cancer treatment –including radiotherapy- particularly for high-surgical-risk, collaborative patients. Key words:Distraction osteogenesis, oral cancer, radiotherapy, reconstruction, dental implants.

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The effect of radiation in distraction osteogenesis for reconstruction of mandibular segmental defects

Cited by 29 publications

References 7 publications

Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone

Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone

Reconstruction mandibulaire en cancérologie : état actuel et perspectives

Lateral transport osteogenesis in maxillofacial oncology patients for rehabilitation with dental implants: a retrospective case series

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