The effect of race on treatment patterns and subsequent health-related quality of life outcomes in men undergoing treatment for localized prostate cancer

Posielski, Natasza; Shanmuga, Santosh; Ho, On; Jiang, Jiji; Elsamanoudi, Sally; Speir, Ryan; Stroup, Sean P.; Musser, John E.; Ernest, Alexander; Chesnut, Gregory T.; Tausch, Timothy J.; Flores, John Paul; Porter, Christopher R.

doi:10.1038/s41391-022-00608-4

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Factors such as immigration and ethnic history may influence race determination, which in turn affects treatment patterns and effectiveness. For instance, Posielski et al stated that AA men were more probable to receive radiation and less probable to receive active surveillance compared to non-AA men for localized prostate cancer [ 88 ]. As such, we acknowledge that race is a social construct, but nonetheless these results highlight important associations.…”

Section: Discussionmentioning

confidence: 99%

The impact of race on survival in metastatic prostate cancer: a systematic literature review

Freedland,

Samjoo,

Rosta

et al. 2023

Prostate Cancer Prostatic Dis

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Background Prostate cancer (PC) is the second most diagnosed cancer in men worldwide. While racial and ethnic differences exist in incidence and mortality, increasing data suggest outcomes by race among men with newly diagnosed PC are similar. However, outcomes among races beyond Black/White have been poorly studied. Moreover, whether outcomes differ by race among men who all have metastatic PC (mPC) is unclear. This systematic literature review (SLR) provides a comprehensive synthesis of current evidence relating race to survival in mPC. Methods An SLR was conducted and reported in accordance with PRISMA guidelines. MEDLINE®, Embase, and Cochrane Library using the Ovid® interface were searched for real-world studies published from January 2012 to July 2022 investigating the impact of race on overall survival (OS) and prostate cancer-specific mortality (PCSM) in patients with mPC. A supplemental search of key congresses was also conducted. Studies were appraised for risk of bias. Results Of 3228 unique records identified, 62 records (47 full-text and 15 conference abstracts), corresponding to 54 unique studies (51 United States and 3 ex-United States) reporting on race and survival were included. While most studies showed no difference between Black vs White patients for OS (n = 21/27) or PCSM (n = 8/9), most showed that Black patients demonstrated improved OS on certain mPC treatments (n = 7/10). Most studies found no survival difference between White patients and Hispanic (OS: n = 6/8; PCSM: n = 5/6) or American Indian/Alaskan Native (AI/AN) (OS: n = 2/3; PCSM: n = 5/5). Most studies found Asian patients had improved OS (n = 3/4) and PCSM (n = 6/6) vs White patients. Conclusions Most studies found Black, Hispanic, and AI/AN patients with mPC had similar survival as White patients, while Black patients on certain therapies and Asian patients showed improved survival. Future studies are needed to understand what aspects of race including social determinants of health are driving these findings.

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Section: Discussionmentioning

confidence: 99%

The impact of race on survival in metastatic prostate cancer: a systematic literature review

Freedland,

Samjoo,

Rosta

et al. 2023

Prostate Cancer Prostatic Dis

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How education level affects postoperative rehabilitation and follow-up: a single-center experience

Yang²,

Chen

et al. 2023

BMC Urol

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Background Radical prostatectomy remains the fundamental treatment for prostate cancer, and improving patients’ compliance with postoperative follow-ups is essential for improving patients’ quality of life. This study investigates the effect of education levels on patients’ recovery and follow-up after radical prostatectomy. Methods Data from 1,112 patients undergoing radical prostatectomy between 2011 and 2020 were collected using medical records, and “pc-follow” systems were used to collect patients’ baseline information, education level, pathological information, number of outpatient visits, the time interval between each visit, and PSA test data. Results Regarding postoperative outpatient data, there was no difference in the number of outpatient visits among the different education level groups in Shanghai (P = 0.063). A significant difference was found in the interval between outpatient visits among the groups (P < 0.001). Furthermore, significant differences were detected in the number and duration of outpatient clinic visits among the education level groups in all patients (P = 0.016, P = 0.0027). By contrast, no significant difference was found in the recovery time of urinary continence between all patients and those in Shanghai, grouped according to education level (P = 0.082, P = 0.68). For all patients and patients in the Shanghai area, the number of PSA follow-ups increased gradually with an increasing level of education (P < 0.001, P = 0.0029). Conclusions Education level affected the number of postoperative clinic visits, compliance, and the number of PSA tests. However, no significant effect on the recovery of urinary continence was found. Further, clinicians must increase their focus on patients with low education levels to achieve equitable access to health services for all patients.

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Association of metabolic syndrome and its components with the risk of urologic cancers: a prospective cohort study

Jiang,

Wang,

et al. 2023

BMC Urol

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Objective To investigate the association between metabolic syndrome (MetS) and its components and the risk of developing urologic cancers. Methods This study included 101,510 observation subjects from May 2006 to December 2007. The subjects received questionnaires and were subjected to clinical and laboratory examinations to collect data on baseline population characteristics, waist circumference (WC), blood pressure (BP), blood glucose, blood lipids, lifestyle, and past disease history. Finally, follow-up was conducted from the date of recruitment to December 31, 2019. Cox proportional hazards modelling was applied to analyze the association between MetS and its components and the risk of developing urologic cancers. Results A total of 97,975 observation subjects met the inclusion criteria. The cumulative follow-up period included 1,209,178.65 person-years, and the median follow-up time was 13.03 years. During the follow-up period, 485 cases of urologic cancers (165 cases of kidney cancer, 134 cases of prostate cancer, 158 cases of bladder cancer, and 28 cases of other urologic cancers) were diagnosed. The log-rank test results for the cumulative incidences of urologic cancer, kidney cancer, and prostate cancer indicated significant (P < 0.01) differences between the MetS and non-MetS groups (0.70% vs. 0.48%, 0.27% vs. 0.15%, and 0.22% vs. 0.13%, respectively). Compared to the non-MetS group, the risk of developing urologic [HR (95% CI) = 1.29 (1.08–1.55)], kidney [HR (95% CI) = 1.74 (1.28–2.37)], and prostate [HR (95% CI) = 1.47 (1.04–2.07)] cancers was significantly higher in the MetS group. In the MetS group, elevated BP increased the risk of developing of urologic cancer [HRs (95% CI) = 1.35 (1.10–1.66)] and kidney cancer [HR (95% CI) = 1.74 (1.21–2.51)], while central obesity increased the risk of developing prostate cancer [HR (95% CI) = 1.68 (1.18–2.40)]. Conclusions MetS increased the risk of developing urologic, kidney, and prostate cancers but had no association with the development of bladder cancer.

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The effect of race on treatment patterns and subsequent health-related quality of life outcomes in men undergoing treatment for localized prostate cancer

Cited by 3 publications

References 35 publications

The impact of race on survival in metastatic prostate cancer: a systematic literature review

The impact of race on survival in metastatic prostate cancer: a systematic literature review

How education level affects postoperative rehabilitation and follow-up: a single-center experience

Association of metabolic syndrome and its components with the risk of urologic cancers: a prospective cohort study

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