The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells

Jakubowicz-Gil, Joanna; Paduch, Roman; Piersiak, Tomasz; Głowniak, Kazimierz; Gawron, Antoni; Kandefer‐Szerszeń, Martyna

doi:10.1016/j.bcp.2005.01.022

Cited by 93 publications

(65 citation statements)

References 53 publications

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“…Our earlier results strongly suggested that the significant decrease in Hsp72 expression after pretreatment with a natural flavonoid, quercetin, was correlated with the highest sensitivity of HeLa cells to cispl- C+I -incubation with both drugs at the same time, IC -preincubation with imperatorin, followed by cisplatin treatment, CI -preincubation with cisplatin, followed by imperatorin treatment. *p < 0.05 atin-induced apoptosis [36]. In the present study, the inhibition of Hsp72 as well as Hsp27 by imperatorin was correlated with increased sensitivity to autophagy rather than apoptosis.…”

Section: Discussionsupporting

confidence: 57%

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Jakubowicz-Gil¹,

Paduch²,

Ulz³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:There is growing evidence that commonly applied chemotherapy regimens can be improved by introducing new, specific, active and low side-effect drugs, or by combining substances to obtain the required clinical effect. The aim of the present study was to investigate the effects of imperatorin and cisplatin, applied separately or in combination, on apoptosis, necrosis and autophagy induction in the human cervical carcinoma cell line (HeLa). Imperatorin appeared to be a potent autophagy inducer, rather than a necrotic or apoptotic one. In contrast, cisplatin induced mainly apoptosis and necrosis after 6 h and 24 h, while longer incubation resulted only in necrosis induction. When HeLa cells were incubated with both drugs, autophagy appeared most frequently, although to a smaller extent than that observed after imperatorin administered alone. At the molecular level, autophagy was correlated with the presence of the cleaved form of microtubule-associated protein 1 light chain LC3 -LC3II. It was also accompanied by the inhibition of heat shock proteins Hsp27 and Hsp72 expression. Our results indicate that imperatorin alone, or in combination with cisplatin, is mainly an autopahgy

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Section: Discussionsupporting

confidence: 57%

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Jakubowicz-Gil¹,

Paduch²,

Ulz³

et al. 2012

Folia Histochem Cytobiol.

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“…2) and sarcodonin G was greater than that induced by 5-Fu, but weaker than that of cisplatin (4). chemotherapeutic anti-cancer agents, including 5-Fu and cisplatin, are known to induce apoptosis (23,24). in the present study, this was demonstrated by dna fragmentation observed in cisplatin-treated Hela cells (Fig.…”

Section: Discussionsupporting

confidence: 57%

Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells

Kita¹

2010

Mol Med Rep

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Abstract. Two abietane and one labdane type diterpenoids were isolated from the methanol extracts of Torreya nucifera pulp and investigated for their ability to inhibit the growth of human cancer cells. among the three compounds, the labdane compound kayadiol was found to have the most effective inhibitory effect against a wide variety of human cancer cells. using the MTT assay, kayadiol was determined to have an ic 50 (50% inhibition concentration) of 30 µM in Hela cells, and also to exhibit anti-proliferative effects towards six other human cancer cell lines, with ic 50 values of 30-50 µM. Kayadiol treatment of Hela cells resulted in a dose-dependent generation of apoptotic events, including dna laddering (≤100 µM). Moreover, kayadiol-treated HeLa cells showed activation of caspases-3 and -9, as well as an increase in the depolarization of mitochondrial membrane potential and the Bax/Bcl-2 ratio. These results indicate that a mitochondriarelated apoptotic pathway is involved in the kayadiol-induced death of Hela cells. Kayadiol is therefore a promising novel anti-proliferative agent and merits further investigation.

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“…Recently, As2O3 was approved by the Food and Drug Administration for use in the treatment of relapsed/refractory acute promyelocytic leukemia, head and neck cancer, neuroblastoma, etc 4,9,15) . The mechanism of action is apoptosis induced by making reactive oxygen species (ROS), change of mitochondrial membrane potential (MMP), decreasing Bcl-2 protein expression, and caspases activation.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Arsenic Trioxide (As₂O₃)- Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

Kim

Ahan

Kim

2007

J Korean Neurosurg Soc

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The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells

Cited by 93 publications

References 53 publications

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells

Enhancement of Arsenic Trioxide (As₂O₃)- Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

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The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells

Cited by 93 publications

References 53 publications

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Cell death in HeLa cells upon imperatorin and cisplatin treatment

Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells

Enhancement of Arsenic Trioxide (As2O3)- Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells

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Enhancement of Arsenic Trioxide (As₂O₃)- Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells