The Effect of Quality of Life on Medication Compliance Among Dialysis Patients

Nagasawa, Hiroyuki; Tachi, Tomoya; Sugita, Ikuto; Esaki, Hiroki; Yoshida, Aki; Kanematsu, Yuta; Noguchi, Yoshihiro; Kobayashi, Yukio; Ichikawa, Etsuko; Tsuchiya, Teruo; Teramachi, Hitomi

doi:10.3389/fphar.2018.00488

Cited by 16 publications

(14 citation statements)

References 38 publications

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“…Kim et al assessed QOL among hemodialysis patient and found similar health-related QOL scores compared to our results [ 33 ]. Also, Nagasawa and colleagues evaluated the effect of QOL on medication compliance among 92 dialysis patients and found QOL-scores comparable to QOL-scores in this report [ 7 ]. Adaptation distress among ICD-recipients in the general population has also been described in several reports [ 11 , 23 ].…”

Section: Discussionmentioning

confidence: 61%

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The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial

et al. 2021

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Rationale The impact of prophylactic implantable cardioverter-defibrillator (ICD) implantation on the psychological well-being of patients on dialysis is unknown. Objective We aimed to identify the effect of primary ICD implantation on quality of life (QoL), mood and dispositional optimism in patients undergoing dialysis. Methods and results We performed a prespecified subanalysis of the randomized controlled ICD2 trial. In total, 177 patients on chronic dialysis, with an age of 55–81 years, and a left ventricular ejection fraction of ≥ 35%, were included in the per-protocol analysis. Eighty patients received an ICD for primary prevention, and 91 patients received standard care. The Short Form-36 (SF-36), Geriatric Depression Scale-15 (GDS-15), Revised Life Orientation Test (LOT-R) questionnaires were administered prior to ICD implantation (T0), and at 1-year follow-up (T1) to assess QoL, depression and optimism, respectively. The patients were predominantly male (76.0%), with a median age of 67 years. Hemodialysis was the predominant mode of dialysis (70.2%). The GDS-15 score difference (T1 − T0) was 0.5 (2.1) in the ICD group compared with 0.3 (2.2) in the control group (mean difference − 0.3; 95% CI − 1.1 to 0.6; P = 0.58). The LOT-R score difference was − 0.2 (4.1) in the ICD group compared with − 1.5 (4.0) in the control group (mean difference − 1.1 (0.8); 95% CI − 2.6 to 0.4; P = 0.17). The mean difference scores of all subscales of the SF-36 were not significantly different between randomization groups. Conclusions In our population of patients on dialysis, ICD implantation did not affect QoL, mood or dispositional optimism significantly during 1-year follow-up. Clinical Trial Registration Unique identifier: ISRCTN20479861. http://www.controlled-trials.com.

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Section: Discussionmentioning

confidence: 61%

“…Multiple studies evaluating QOL in patients on dialysis report high rates of depression and anxiety [ 6 , 7 , 33 ]. Kim et al assessed QOL among hemodialysis patient and found similar health-related QOL scores compared to our results [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial

et al. 2021

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“…More recently, Alves et al (31) confirmed the positive correlation between the quality of life and drug compliance, suggesting that non-adherence to medication regimens could aggravate the quality of life of patients due to complications such as readmission and imposition of extra treatment costs. Several studies have also reported that treatment interventions aimed at improving lifestyle and sleep quality of hemodialysis patients help prevent some adverse effects of medication, which deteriorate the quality of life of these individuals (19)(20)(21)(22). Guerra-Guerrerro et al (9) reported that follow-up and adherence to the treatment can yield a positive impact on the quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Pour Shaban et al (18), it was found that modifying the diet of non-dialysis people with chronic kidney disease helps reduce mortality and the complications caused by increased toxins in the body. Given that most hemodialysis patients undergo the treatment procedure 3 times a week, compliance with the regimen is an integral part of the management of these people, which deeply affects their quality of life (19). Similarly, Guerra-Guerrerro et al (9) suggested that the quality of life of hemodialysis patients could be improved by increasing their treatment regimen compliance.…”

Section: Introductionmentioning

confidence: 99%

Probing the Relationship Between Treatment Regimen Compliance and the Quality of Life in Hemodialysis Patients: A Descriptive-Analytic Study

et al. 2019

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Background: Non-adherence to treatment regimens can bring about negative effects on the quality of life of hemodialysis patients. Objectives: The present study was conducted to explore the relationship between compliance with treatment regimens and the quality of life in these patients. Methods: This descriptive-analytic study investigated 68 hemodialysis patients who had referred to Imam Khomeini Hospital of Zabol, Southeast of Iran. The subjects were chosen via convenience sampling. Data were collected using a demographic questionnaire, a self-constructed scale for treatment regimen compliance, and the kidney disease quality of life short form (KDQOL-SF). Descriptive statistics, Pearson correlation coefficient, and t-test were used to analyze the data by SPSS 22. Results: The results showed that 77% of patients moderately adhered to treatment regimens, and the mean quality of life in hemodialysis patients was 56.36 ± 17.41. Pearson correlation coefficient revealed a positive significant relationship between the quality of life and compliance with treatment regimens in the study population (P = 0.02). Conclusions: According to the findings of this study, it is recommended that appropriate educational programs should be designed to improve the quality of life in hemodialysis patients by encouraging their adherence to treatment regimens.

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“…The complexity of medication regiments and the high number of drugs that are administered in ESRD patients can also lead to the appearance of drug-drug interactions (DDIs) that can be the pharmacological underlying reason for ADRs [18,19]. Overall, the presence of ADRs in ESRD patients can be related to impaired quality of life, possible hospital re-admissions in case of life-threatening ADRs, poor adherence and compliance and increased healthcare costs [14,[20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece

Spanakis

Roubedaki

Tzanakis

et al. 2020

IJERPH

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Background: Patients with end-stage renal disease (ESRD) require specialized therapeutic interventions. The decreased renal function that modulates the physiology and presence of comorbidities is often associated with variations in the pharmacological response, thus increasing the risk of adverse drug events or reactions (ADE/ADRs) from co-administered drugs. Methods: A cross-sectional study to record comorbidities, drug–drug interactions (DDIs), ADE/ADRs in patients with chronic kidney disease of stage five in Greece. The study enrolled 60 patients of mean age 64.8 ± 12.9 years, undergoing hemodialysis three times a week. Demographic and social factors, comorbidities, laboratory test data, medication regimens, DDIs and the reporting of ADE/ADRs were analyzed. Results: Cardiovascular diseases and diabetes were the main comorbidities. In total, 50 different DDIs of various clinical significance were identified. CNS, GI-track, and musculoskeletal-system-related ADE/ADRs were most often reported by patients. ADE/ADRs as clinical outcome from DDIs were associated in 64% of the total identified DDIs. There was a positive trend between number of medications, ADE/ADRs report and DDIs. Conclusions: The impact of ADE/ADRs in ESRD patients should be always considered. Guidelines as well as continuous training in the context of evidence-based clinical practice by healthcare personnel on therapy administration and prevention of adverse events are important.

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The Effect of Quality of Life on Medication Compliance Among Dialysis Patients

Cited by 16 publications

References 38 publications

The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial

The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial

Probing the Relationship Between Treatment Regimen Compliance and the Quality of Life in Hemodialysis Patients: A Descriptive-Analytic Study

Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece

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