The effect of pyriproxyfen on the motoric activity of rat intestine - In vitro study

Chłopecka, Magdalena; Mendel, Marta; Dziekan, Natalia; Karlik, Wojciech

doi:10.1016/j.envpol.2018.06.046

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Pyriproxyfen has been approved by the World Health Organization as safe for use even in potable water [World Health Organization (WHO), 2006]. It is highly toxic during all stages of mosquito development, suppresses metamorphosis (Chłopecka et al, 2018), and interferes in insect reproduction and proliferation. It acts as an analog of juvenile insect hormone, a growth regulator [Ishaaya and Horowitz, 1992;World Health Organization (WHO), 2006;Chłopecka et al, 2018].…”

Section: Introductionmentioning

confidence: 99%

“…It is highly toxic during all stages of mosquito development, suppresses metamorphosis (Chłopecka et al, 2018), and interferes in insect reproduction and proliferation. It acts as an analog of juvenile insect hormone, a growth regulator [Ishaaya and Horowitz, 1992;World Health Organization (WHO), 2006;Chłopecka et al, 2018]. Pyriproxyfen may also act as an acetylcholinesterase inhibitor in fish (Araújo et al, 2018;Maharajan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish

Gusso

Reolon

Gonzalez

et al. 2020

Front. Behav. Neurosci.

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Pyriproxyfen is one of the most used larvicides and insecticides; it acts as an analog of juvenile insect hormone (a growth regulator). It is highly toxic during all stages of mosquito development, suppresses metamorphosis, and interferes in insect reproduction and proliferation. Pyriproxyfen and its main metabolite have been shown to affect brain development in rodents. This compound is employed mainly to eliminate outbreaks of the genus Aedes, even in potable water. Despite the increasing number of toxicological studies about larvicides and insecticides-with an indication of continuous use-there have been few studies about the effects of pyriproxyfen in non-target species such as fish. This study evaluated the effects of pyriproxyfen on behavioral, cognitive, and endocrine parameters in zebrafish. We exposed adult zebrafish to different pyriproxyfen (Pestanal) concentrations (0.125, 0.675, and 1.75 mg/l) for 96 h. We analyzed behavioral parameters, memory, cortisol levels, and gene expression of glucocorticoid receptor (gr) and corticotrophin-releasing factor (crf) after pyriproxyfen exposure. This exposure did not alter locomotion (distance or mean speed), anxiety-like behavior (latency to enter to the top zone of the tank or time in the top zone of the tank), and social or aggressive behavior. However, there was impaired inhibitory avoidance memory at all tested pyriproxyfen concentrations. Cortisol levels were reduced in exposed groups when compared to control or vehicle. However, gr and crf gene expression in pyriproxyfen-treated animals were unaltered when compared to control or vehicle groups. Taken together, these findings indicate that pyriproxyfen may induce cognitive impairment and altered cortisol levels in zebrafish, a non-target species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish

Gusso

Reolon

Gonzalez

et al. 2020

Front. Behav. Neurosci.

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“…2009). However, there are few experimental reports aimed at evaluating the potential mechanisms of PPF toxic effect in vertebrates (in in vitro and in vivo conditions) in recent years (Chlopecka et al, 2018). In invertebrates its toxicity has been widely studied, in which PPF can cause mortality in aquatic invertebrates and small fi sh (Maharajan et al, 2018).…”

Section: Saccharomyces Cerevisiaementioning

confidence: 99%

GERMINAÇÃO DE SEMENTES DE MARACUJÁ (Passiflora edulis) COM DIFERENTES TEMPOS DE IMERSÃO EM ÁCIDO SULFÚRICO

Nunes¹,

Rambo²,

Costa³

et al. 2020

Ciências Agrárias: Conhecimentos Científicos E Técnicos E Difusão De Tecnologias 3

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Direitos para esta edição cedidos à Atena Editora pelos autores.

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“…Pyriproxyfen, a broad spectrum insect growth regulator that interferes with insect development, was first synthesized and developed by Sumitomo Chemical Co., Ltd, in the 1990s 1 . Its distinctive mechanism of action makes it more selective and therefore safer than conventional insecticides for non‐target organisms 2 . Pyriproxyfen exhibits strong biological activity against public health insect pests such as houseflies, 3,4 mosquitoes 5‐7 and cockroaches 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Residue degradation, transfer and risk assessment of pyriproxyfen and its metabolites from tea garden to cup by ultra performance liquid chromatography tandem mass spectrometry

et al. 2022

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BACKGROUND Tea is one of the most popular drinks in the world. The growth of tea plant is inseparable from the control of pesticides on diseases and pests. Pyriproxyfen is used as a pesticide substitute to control insect pests in tea gardens, but little is known about its residue degradation. Here, we performed an integrative study of the degradation and metabolism of pyriproxyfen from the tea garden to the cup. RESULTS The dissipation half‐life of pyriproxyfen during tea growth was 2.74 days, and five metabolites PYPAC, PYPA, DPH‐Pyr, 5′′‐OH‐Pyr, and 4′‐OH‐Pyr were generated. The total processing factors for pyriproxyfen in green tea and black tea were 2.41–2.83 and 2.77–3.70, respectively. The residues of pyriproxyfen and its metabolites were affected by different processing steps. The total leaching rates of pyriproxyfen from green tea and black tea into their infusions were 9.8–12.3% and 5.3–13.8%, respectively. The leaching rates of the five metabolites were higher than that of pyriproxyfen and increased the intake risk. CONCLUSION To ensure safe consumption, the recommended maximum residue limit value of pyriproxyfen in tea can be set to 5 mg kg−1 and the pre‐harvest interval can be set to 5 days. © 2022 Society of Chemical Industry.

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The effect of pyriproxyfen on the motoric activity of rat intestine - In vitro study

Cited by 8 publications

References 22 publications

Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish

Pyriproxyfen Exposure Impairs Cognitive Parameters and Alters Cortisol Levels in Zebrafish

GERMINAÇÃO DE SEMENTES DE MARACUJÁ (Passiflora edulis) COM DIFERENTES TEMPOS DE IMERSÃO EM ÁCIDO SULFÚRICO

Residue degradation, transfer and risk assessment of pyriproxyfen and its metabolites from tea garden to cup by ultra performance liquid chromatography tandem mass spectrometry

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