The Effect of Purified Micronized Flavonoid Fraction on the Healing of Anastomoses in the Colon in Rats

İnan, Aydın; Şen, Meral; Koca, Cemile; Akpinar, Ayhan; Dener, Cenap

doi:10.1007/s00595-006-3251-4

Cited by 17 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From a clinical aspects, collagen deposition in the wound is the most essential phase of healing. Facilitating oxygen diffusion, diminishing oxygen free radical overproduction, and increases collagen synthesis were together found for improve healing [47] . Collagen is a major protein of the extracellular matrix and is the component that ultimately contributes to wound strength.…”

Section: Discussionmentioning

confidence: 99%

Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats

Lodhi¹,

Jain²,

Rai³

et al. 2016

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

BackgroundBambusa vulgaris (Family: Poaceae) used in Ayurveda for paralytic complaints, inflammatory disorders and externally to skin disorders. It has various medicinal uses with good nutritional composition and a rich source of vitamins, proteins, amino acid, beta-carotene and phenolic compounds.ObjectiveThe present study was aimed to evaluate wound healing and anti-inflammatory potential of ethanol extract of B. vulgaris leaves in rats.Materials and methodsThe B. vulgaris leaves were evaluated for wound healing on incision and excision wound methods. Anti-inflammatory effect was evaluated by measurement of paw edema in carrageenan-induced inflammation in rats. Ethyl acetate (BVL-A) and aqueous (BVL-B) fractions from the ethanol extract of leaves were screened for wound healing effects by measuring tensile strength and biochemical parameters in incision wound method. The wound contraction area, antioxidant status and histopathological studies were done in excision wound method.ResultsTensile strength and hydroxyproline level of 5% w/w ointment of BVL-A and BVL-B treated groups were found significantly (P < 0.01) higher and comparable to the reference group. The histopathological study showed the proliferation of collagen, fibrous tissue, and capillaries with epidermal covering at the margin of the wound. The percent inhibition of paw edema was significantly decrease by increasing concentration of BVL-A and BVL-B fractions. In addition, it was found that B. vulgaris possesses antioxidant properties, by its ability to increase antioxidants level.ConclusionsThe results obtained in the present study were indicated that ethyl acetate fraction of B. vulgaris leaves inhibits paw edema and accelerates cutaneous wound healing.

show abstract

Section: Discussionmentioning

confidence: 99%

Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats

Lodhi¹,

Jain²,

Rai³

et al. 2016

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

show abstract

“…From a clinical point of view, collagen deposition in the wound is the most important phase of healing. Facilitating oxygen diffusion, increasing lymphatic drainage, diminishing oxygen free radical overproduction and increasing the collagen synthesis were together found to improve healing [28] .…”

Section: Discussionmentioning

confidence: 99%

“…This was left to stand for 10 min and then treated with Folin-Ciocalteau reagent that resulted in a bluish color in [20][21][22][23][24][25][26][27][28][29][30] min. The absorbance was measured in UV (Cintra) Spectrophotometer at 660 nm [14] .…”

Section: Protein Estimationmentioning

confidence: 99%

Preliminary pharmacological evaluation of Martynia annua Linn leaves for wound healing

Lodhi

Singhai

2011

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…In addition, group IV was treated with a single dose of 3.5 mg/kg body weight DZ intraperitoneally on day 5 post-infection, but group II was left untreated. Groups III and V were first pre-treated with 100 mg/ kg [18,19] body weight DF, once daily for 14 days per os, and then infected with 10 6 trypanosomes/ml of blood. After infection, treatment with DF continued daily for three weeks.…”

Section: Experimental Designmentioning

confidence: 99%

Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Pi¹,

Ayo²,

Aluwong³

et al. 2014

Biol Med (Aligarh)

View full text Add to dashboard Cite

The aim of the study was to evaluate the effect of treatment with DAFLON® 500 mg (DF) and/or diminazene aceturate (DZ) on hematological parameters in rats, infected with Trypanosoma brucei brucei. Rats in the control group were administered with distilled water (DW) only (5 mL/kg), while those in other groups were infected with Trypanosoma brucei brucei (10 6 cells/ml), and treated with DF and/or DZ. Packed cell volume (PCV), haemoglobin (Hb) concentration, erythrocyte (RBC) and neutrophil counts were lower in the infected untreated and DF-treated group, than in any other group. Total leucocyte, lymphocyte, platelet counts and mean corpuscular volume (MCV) decreased in the infected untreated group, compared to values obtained in those administered with DF and/or DZ. The MCV reduced in the DZ-treated group, compared to the groups treated with DF and the combination of DF and DZ. Mean corpuscular haemoglobin concentration (MCHC) was lower in the infected untreated and DF treated group than in the DW or DZ group. Rats administered with DZ had higher leucocyte and lymphocyte counts compared to those in DF-treated group. It is concluded that the administration of DF and/or DZ ameliorated the anaemia caused by Trypanosoma brucei brucei -infection in Wistar rats.

show abstract

The Effect of Purified Micronized Flavonoid Fraction on the Healing of Anastomoses in the Colon in Rats

Abstract: Although the micronized purified flavonoid fraction has some inhibitory properties on the healing of the anastomosis, its net effect was to obtain a better anastomotic healing of the colon in rats.

Cited by 17 publications

References 37 publications

Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats

Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats

Preliminary pharmacological evaluation of Martynia annua Linn leaves for wound healing

Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Contact Info

Product

Resources

About